Naegleria Flashcards

1023830599	Naegleria	are free living aerobic amoebae with several life stages, live in soil, freshwater. reproduce by binary fission of trophozoite
1023830600	Naegleria life stages	1.trophozoite-motile, feeding stage, food cups, favorable conditions, move using psuedopodium 2. flagellate stage- have flagella and basal bodies, dependent of transcription and translation 3. cyst- quiescent, resistant, infective, anoxia, pH changes, dessication
1023830601	Naegleria Pathogenesis	opportunistic => colonization of nasal mucosa asymptomatic => colonization can result in primary amoebic meningoencephalitis => host response via complement
1023830602	pathogenic species	humans- N. fowleri mice- N. australiensis, N. lovaniensis
1023830603	non-pathogenic species	N. gruberi, N. jadini, N. thorntoni
1023830604	Naegleria symptoms	frontal lobe headache, stiff neck, altered taste and smell, and fever
1023830605	Naegleria signs	purulent, bloody CSF with elevated PMNs, RBC, and amoebae nasal discharge, increase in protein, decrease in glucose, Kernig's sign
1023830606	Naegleria pathology	trophozoites within tissue not cysts. stain saline preps with Iodine- presenceo f amoebae is diagnostic. differential diagnosis- Acanthoamoeba, Balamuthia
1023830607	Naegleria treatment	amphotericin B, Miconazole, and rifampicin F together corifungin- new macrolide Miltefosine (investigational)- used for leishmaniasis. efficacy vs amoeba in lab (Naegleria, Balamuthia mandrillis, and Acanthoamoeba