Kinetics Final Flashcards
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| 1065637714 | 4 examples of continuous input | 1) I.V. drip 2) I.V. infusion 3) Transdermal patch 4) Sustained release oral dosage forms | 0 | |
| 1065637715 | What is the rate of infusion signified by? | Ko | 1 | |
| 1065637716 | What is the relationship between the amount of drug in the body and the rate of input and rate of clearance in continuous infusion? | dA/dt = rate in - rate out rate in = input rate (amount/time); represented by Ko rate out = elimination rate constant x amount of drug in body = (Ke x A) dA/dt = Ko - KeA | 2 | |
| 1065789403 | What is dA/dt at plateau of continuous infusion? | aka at STEADY STATE dA/dt = 0 at max Cp (aka Cp,ss) rate in = rate out | 3 | |
| 1065789404 | What is infusion rate (Ko) determined by at steady state? | Clearance and Steady State Concentration: Ko = CL x Cp,ss | 4 | |
| 1065789405 | Assuming 1-compartment model, when infused continuously at the same rate, all drugs with the same CLEARANCE will have the same _?_ | steady-state plasma concentration (Cp,ss) | 5 | |
| 1065789406 | Assuming 1-compartment model, when infused continuously at the same rate, all drugs with the same HALF-LIFE will have the same _?_ | steady-state amount of drug in the body (A,ss) | 6 | |
| 1065789407 | How long does it take to reach steady state in a continuous infusion? | 3.3 half lives to reach 90% of Cp,ss | 7 | |
| 1065789408 | For continuous infusion at steady state, the term e^(-Ke*t) is equal to ? | = 0.1 t½ = 0.693 / Ke → Ke = 0.693 / t½ t = 3.3(t½) →t½ cancels out, so gives e^(0.693*3.3) = 0.1 | 8 | |
| 1065789409 | What happens to Cp,ss , A,ss , and Time to SS (steady state) when ↑ Ko? | ↑ Cp,ss ↑ A,ss no change in Time to SS | 9 | |
| 1065789410 | What happens to Cp,ss , A,ss , and Time to SS when ↑ CL? | ↓ Cp,ss ↓ A,ss ↓ Time to SS | 10 | |
| 1065789411 | What happens to Cp,ss , A,ss , and Time to SS (steady state) when ↑ V? | no change in Cp,ss ↑ A,ss ↑ Time to SS | 11 | |
| 1065789412 | What happens to Volume of Distribution if a displacement interaction takes place, i.e. something displaces drug bound to plasma proteins, as a result increasing the amount of free drug in the plasma? | Increases Volume of Distribution | 12 | |
| 1065834716 | What is the value of Cp,o when it is within ±10% of Cp,ss? | Cp,o = 0 | 13 | |
| 1065834717 | When Cp,o ≠ 0, the time to ±10% of Cp,ss is (the same? different?) as t₉₀% | the time to ±10% of Cp,ss is DIFFERENT from the t₉₀% | 14 | |
| 1095474408 | ... | 1st row (↑K₀): ↑ ↑ → 2nd row (↑CL): ↓ ↓. ↓ 3rd row (↑V): → ↑ ↑ |  | 15 |