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B12 deficient anemia Flashcards

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3580880764How does gastric acid affect B12Suppressing Gastric acid can increase the risk of B12 anemia by inhibiting cobalamin release from food0
35808813253 causes of B12 deficiency anemiainadequate intake malabsorption syndromes inadequate utilization1
3580882863Pernicious anemialoss of intrinsic factor2
3580883201Why does intrinsic factor domoves cobalamin around the body3
3580883588PathophysiologyB12 is a building block of DNA and RNA Maintains integrity of the neurologic system plays a role in fatty acid biosynthesis and energy production4
3580884721Symptoms of B12 deficiencybilateral paraesthesia in extremities deficits in proprioception and vibration can progress to ataxia, dementia-like symptoms, psychosis, and vision loss5
3580888500Lab findingsMCV >100 Serum B12 <150 Low reticulocyte count low hematocrit elevation in MMA elevation in homocysteine6
3580892466Treatment of pernicious1000-2000mcg B12 orally can be used for pernicious anemia for life7
3580893729Treatment of symptomatic1000mcg cyanocobalamin IM daily for one week to resolve clinical manifestations then give weekly for one month and monthly after that8
3580894640SEhyperuricemia, hypokalemia9
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