Virus Flashcards

3851515673	DNA Viruses	Hep, Herpes, Adenoviridae, Poxviridae	0
3851521756	Virus inner shell called, made of	Capsid (holds DNA or RNA), protein	1
3851523547	Steps for Self-Replication	Adsorption, Penetration and Uncoating, Biosynthesis, Maturation and Release (exocytosis or lysis(	2
3851531036	Envelope of virus is made of	lipid bilayer	3
3851555669	Acyclovir and Valacyclovir: Effective against	Herpes virus	4
3851556901	Acyclovir and Valacyclovir: Which viruses	Varicella zoster, Epstein Barr	5
3851558663	Acyclovir and Valacyclovir: How aadministered	topical, systemic	6
3851561029	Acyclovir and Valacyclovir: MOA	Inhibits DNA replication	7
3851564610	Acyclovir and Valacyclovir: Inhibits what enzyme?	DNA polymerase	8
3851566617	Valacyclovir is converted in	Intestines and liver	9
3851574731	Amantadine and Rimantadine: Use	Influenza A	10
3851577973	Amantadine and Rimantadine: MOA	Block un-coating and block assembly of vital components	11
3851581848	Amantadine and Rimantadine: Adverse Effects	CNS, OD- seizures	12
3851587138	Famiciclovir and Peniciclovir: Use	Cold sores (Herpes Zoster/Genital Herpes)	13
3851591832	What 2 drugs are activated within infected cells and then inhibit viral DNA synthesis/replication?	Acyclovir (Valacyclovir) and Penicyclovir (Famiciclovir)	14
3851602331	Adverse Effects Famiciclovir and Peniciclovir	Irritation over site (topical), Some HA, dizziness, GI (oral)	15
3851611962	Protease Inhibitors	Inhibit HIV protease	16
3851613407	Protease Inhibitors MOA	prevent cleavage of polypeptide precursors, prevents maturation	17
3851616951	Protease Inhibitors Adverse Effects	Lipodystrophy, insulin resistance, metabolic syndrome	18
3851632698	Protease inhibitors: Combine with __ to have therapeutic effect at a lower dose	Ritonair	19
3851636979	Reverse Transcriptase Inhibitors: Use	HIV-1	20
3851638586	Reverse Transcriptase Inhibitors: MOA	Act on HIV reverse transcriptase (reduce proliferation, halt progress)	21
3851652289	NRTI: inhibit, act as a	RNA to DNA, false nucleic acid	22
3851660814	NNRTI: act on	different site for same enzyme	23
3851662240	RTI Adverse effect	blood dyscrasias (anemia and zidovudine)	24
3851664171	NRTI Adverse Effect	Myopathies, peripheral neuropathies	25
3851665656	NNRTI Adverse Effect	Skin rashes	26
3851670993	Ribavarin Use	RSV (respiratory syncythial virus), Influenza A and B, Hep C (combine with interferons)	27
3851673590	Ribavarin MOA	Inhalation, Impair mRNA synthesis	28
3851675001	Ribavarin Adverse Effects	Conjunctivitis- contact with eyes	29
3851681414	Interferons activate __ to limit excess cell division	lymphocytes and cytotoxic cells	30
3851684714	Type 1 Interferons (alpha and beta) combat	Virus	31
3851686941	Type 2 (gamma) produces__ and combats __	T lymphocytes, inflammation	32
3851693869	Role of Oncogenes	Interferons inhibit specific gene regulatory segments of tumor cells, this stops excess proliferation and lack of cell differentiation (anti-cancer)	33
3851696602	Type 1 Interferons helpful for	Helpful for Hep B and C, MS type 1	34
3851705347	Adverse effects interferons	Flu-like, behavioral	35
3851707643	Vaccines are __-like	antigen	36
3851709192	HIV and AIDS belong to __ family	retrovirus	37
3851711035	HIV 1 or 2 is more prevalent	1	38
3851712722	HIV has what neurological involvement?	neuropathies, myopathies	39
3851712723	Tx	HAART	40
3851713847	HAART example	2 RTI and 1 protease inhibitor	41
3851716802	HAART reduces	viral load	42
3851720056	even if viral load decreases, there can still be some in __ and other reservoirs	T cells	43