Hematology: Vitamin B12 deficiency Flashcards
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| 3283114120 | Pernicious anemia | Important cause of B12 deficiency, autoantibodies to IF | 0 | |
| 3283114121 | Pernicious anemia: type 1 antibody | 75% patients have this, which blocks binding of B12 to IF | 1 | |
| 3283114122 | Pernicious anemia: type 2 antibody | Prevent binding of IF to ileal receptors | 2 | |
| 3283114123 | Pernicious anemia: type 3 antibody | Blocks IF production, present in 85-90% of patients | 3 | |
| 3283114124 | Pernicious anemia: principle alterations | Involve the spinal cord, where therein is myelin degeneration of the dorsal and lateral tracts | 4 | |
| 3283114125 | Pernicious anemia: clinical course | Large RBC, decreased platelets and WBCs, increased segments in nucleus in neutrophils | 5 | |
| 3283114126 | Schilling test | Useful in distinguishing B12 deficiency due to malabsorption, dietary deficiency, or absence of IF | 6 |