Vitamin B12 deficiency Flashcards
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| 5703278503 | Vit. B12 | - Cofactor in conversion of homocysteine to methionine - Cofactor in conversion of methyl malonyl- CoA to succinyl CoA - The mechanism of n.s. damage in B12 def. is unclear, thought to be impaired in myelin synthesis | 0 | |
| 5703309463 | Causes | - Malabsorption of vit. B12 reflecting lack of intrinsic factor - after gastrectomy - fish tapeworm - celiac disease - gastric malignancy - thyrotoxicosis - extreme vegetarian diet | 1 | |
| 5703332530 | Clinical syndromes | - Subacute combined degeneration of the spinal cord - Polyneuropathy - Dementia / encephalopathy ** Roomberg = positive Cerebellar syndrome Optic neuritis | 2 | |
| 5703379877 | Diagnosis | - Serum vit. B12 - Complete blood count (75% have megaloblastic anemia) | 3 | |
| 5703388600 | Supplementation | 1000 micrograms daily for a week 1000 micrograms weekly for a month 1000 micrograms monthly for life | 4 |