The TCR and MHC molecules Flashcards
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| 4563590858 | What does CD mean in reference to CD4 or CD8? | Cluster of differentiation | 0 | |
| 4563613413 | MHC class 2 recognized by | CD4+ T cells | 1 | |
| 4563613414 | MHC class 1 recognized by | CD8+ T cells | 2 | |
| 4563620088 | *The T cell receptor is made of two variable domains (Valpha and Vbeta), which make up the antigen recognition site (flip) | There is an alpha chain and a beta chain that make up the TCR. Each chain has a constant and variable region | 3 | |
| 4563630675 | Approximately how long are T cell epitopes in amino acids | 8-12 amino acids long (can be longer for MHC class 2) | 4 | |
| 4563634653 | *T cell epitopes can be from anywhere in the folded structure of a protein, ie can be either surface exposed or buried within the folded protein | 5 | ||
| 4563685936 | MHC class 1 molecules are expressed on the cell surface by all _________ cells | nucleated | 6 | |
| 4563688928 | MHC class 1 molecules present _____ (endogenous) antigens from within the APC | intracellular | 7 | |
| 4563692763 | CD8+ cytotoxic T lymphocytes kill abnormal cells such as cells that are _____ infected or which are _______ | virally cancerous | 8 | |
| 4563702962 | MHC class 2 molecules are expressed on the cell surface of _____ antigen presenting cells such as _____, ______, and ____ | professional B cells dendritic cells macrophages | 9 | |
| 4563718770 | When discussing MHC class 1, in what site is the antigen processed? | Cytosol (proteasome) | 10 | |
| 4563720091 | When discussing MHC class 2, in what site is the antigen processed? | Endosome | 11 | |
| 4563721459 | When discussing MHC class 1, in what site is the peptide loaded? | Endoplasmic reticulum (ER) | 12 | |
| 4563723974 | When discussing MHC class 2, in what site is the peptide loaded? | Endosome | 13 | |
| 4563750782 | MHC molecules have ___ extracellular domains, ___ of which form the peptide binding site | 4 2 | 14 | |
| 4563752113 | MHC class 1 molecules comprise the ____ chain and ________ | Heavy Beta-microglobulin | 15 | |
| 4563754031 | MHC class 2 molecules comprise the __ and __ chains | alpha beta | 16 | |
| 4563758916 | *MHC molecules are expressed on the plasma membrane | 17 | ||
| 4563762388 | *the TCR binds to both the MHC molecule and the antigenic peptide | 18 | ||
| 4563858898 | Class 1 region codes for MHC class 1 heavy chains called? (3) | HLA-A HLA-B HLA-C | 19 | |
| 4563861723 | Class 2 region codes for MHC class 2 molecules called? (3) | HLA-DR HLA-DP HLA-DQ | 20 | |
| 4563864576 | Class 3 codes for some ____ proteins and some ____ | complement proteins cytokines | 21 | |
| 4563872658 | *The MHC molecules are polygenic... there is more than one gene for the MHC class 1 and MHC class 2 molecules | 22 | ||
| 4563879124 | MHC molecule genes are found on the short arm of chromosome __? | chromosome 6 | 23 | |
| 4563978518 | Mismatched MHC molecules make tissues and organs ______ | Histoincompatible (ideal donors for transplants are identical twins- 100% matched) | 24 | |
| 4564350755 | *polymorphic residues are concentrated within the peptide binding grove of MHC class 1 molecules | 25 | ||
| 4564359455 | *by expressing up to 6 different MHC class 1 and 6 different MHC class 2 molecules, we increase the number of different peptides we can present to T cells | 26 | ||
| 4564391585 | *variation between alleles is concentrated in peptide binding site and affects the peptides that are bound and presented to T cells | 27 |