B12 Tough Pharm Drugs Flashcards
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| 5598641395 | Anastrazole | Selective aromatase inhibitor (reversible) Tx: PM hormone dependent B Cx | 0 | |
| 5598652711 | Exemestane | Irreversible aromatase inhibitor Tx: PM hormone dependent B Cx | 1 | |
| 5599896132 | Norethindrone | Progestin only Mini-pill -- 99.0% effective "thin" = no baby | 2 | |
| 5599901921 | Norgestrel | Progestin only Mini-pill -- 99.0% effective don't "gest" about being pregnant (don't confuse w/ norgESTIMATE) | 3 | |
| 5600000551 | Ethinyl estradiol | Estogen portion of COC "thin" = no baby | 4 | |
| 5600000553 | Mestranol | Estrogen portion of COC | 5 | |
| 5600124318 | Norgestimate | Progestin only No Estrogen effects "estimate" 0 Estrogen effects | 6 | |
| 5600185985 | Mifepristone | Competitive inhibitor of progesterone receptor *Abortion pill* through day 49 "muff" the baby like the 49'ers muff punts | 7 | |
| 5631017832 | Aminoglutethimimde | Corticosteroid inhibitor MOA: Inhibits p450 scc Tx: Cushing disease | 8 | |
| 5631024977 | Ketoconazole | MOA: Inhibits C17-20 lyase Tx: Cushing's, Hirsutism inhibits gonadal and adrenal steroid synthesis... Corticosteroid inhibitor and anti-androgen | 9 | |
| 5631043356 | Spironolactone | Corticosteroid inhibitor MOA: antag aldosterone synthesis and testosterone synthesis <-- reduces [C17-20 lyase] Tx: Hirsuitism, HTN Corticosteroid inhibitor and anti-androgen SE: hyperkalemia, gynocomastia | 10 | |
| 5631072815 | Eplerenone | Corticosteroid inhibitor Tx: anti-HTN, heart failure MOA: Aldosterone antag *No gynocomastia* | 11 | |
| 5631186915 | 17B-hydroxysteroid dehydrogenase | androstenedione --> testosterone | 12 | |
| 5631194810 | 5 alpha reductase | Testosterone --> DHT | 13 | |
| 5631223046 | Abiraterone | Antiandrogen Tx: metastatic castration resistant prostate cancer MOA: inhibits CYP17 SE: hepatotoxic | 14 | |
| 5631232569 | *Flutamide* | Antiandrogen Tx: prostate cancer MOA: competitive inhibitor of DHT binding to androgen receptor SE: hepatitis, anemia | 15 | |
| 5631247919 | *Finasteride* | Antiandrogen Tx: BPH, bladness MOA: 5 alpha reductase inhibitor finAsteRIde...Alpha Reductase Inhibitor | 16 | |
| 5631285387 | PDE5 | cleaves cGMP --> erection "afils" are PDE5 inhibitors cGMP --> smooth muscle relaxation | 17 | |
| 5634088668 | Cincalet | PTH drug MOA: Calcimimetic, lowers PTH by activating Ca++ sensing receptors in PT gland Tx: Hypercalcemia | 18 | |
| 5634099248 | Teriparatide | Recombinant PTH MOA: up serum Ca++, up osteoclast activity, decrease serum phosphate Low dose or intermittant = bone formation b/c PTh signals osteoblasts which then signal osteoclasts Tx: Osteoporosis | 19 | |
| 5634118187 | Calcitriol Ergocalciferol, Cholecalciderol, DHT (dihydrotachysterol) | Replaces Vit D, decrease PTH Tx: Rickets, Osteomalacia, SE: GI pain, kidney stones | 20 | |
| 5634177883 | Calcitriol what form of Vit D? | 1, 25 OH Active | 21 | |
| 5634182749 | Ergocalciferol what form of Vit D? | D2 | 22 | |
| 5634182750 | Cholecalciferol what form of Vit D? | D3 | 23 | |
| 5634185291 | Dihydrotachysterol what form of Vit D? | Dihydrotachysterol shortest t1/2 | 24 |