AP Review Flashcards
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| 4948399418 | Vascular lesions of the spleen | - Hemangioma - Peliosis (dilated sinuses lined by CD8/CD68 positive cells) - Littoral cell angioma (cuboidal or papillary cells, CD8/cd34-, CD68/163 +) - Hemangioendothelioma (more atypia with low mitotic rate, no necrosis) - Angiosarcoma (infiltrative, mitoses, necrosis, atypia) - Lymphangioma (proteinaceous material, cells D2-40/31/F8+, 34-) | 0 | |
| 4948601392 | Oligodendroglioma | - white matter of frontal lobe - fried-egg appearance - del 1p and 19q have prognostic significance |  | 1 |
| 4948601393 | Central core disease | - type of myopathy with a strong association with malignant hyperthermia - Autosomal dominant mutation in RYR1 (19q) - Clear areas in myocytes with NADH stain | 2 | |
| 5106935161 | Intramuscular parasite | trichinosis |  | 3 |
| 5106956120 | translocation in mucoepidermoid carcinoma | t(11;19), MECT1-MAML2 fusion | 4 | |
| 5106970457 | Most common benign and malignant tumors of the salivary gland | Benign: pleomorphic adenoma Malignant: Mucoepidermoid carcinoma | 5 | |
| 5106980696 | odontogenic keratocyst | - locally destructive cyst - squamous lining with parakeratosis, basal palisading, and wavy surface - 50% associated with unerupted tooth - A/w Gorlin syndrome |  | 6 |
| 5106998278 | Ameloblastoma | - a/w impacted tooth - locally aggressive - islands of stellate epithelial cells surrounded by basal cells with reverse polarity - Malignancy defined by mets |  | 7 |
| 5107023082 | Fibrous dysplasia is associated with which hereditary syndrome? | McCune Albright syndrome | 8 | |
| 5107030635 | Epithelial myoepithelial carcinoma | - P63, S-100, calponin, and SMA positive - Inner ductal cells and outer myoepithelial cells with clear cytoplasm - Rare malignant salivary gland tumor |  | 9 |
| 5107053596 | Granular cell tumor cell of origin | Schwann cell | 10 | |
| 5107055637 | GIST cell of origin | Cells of Cajal | 11 | |
| 5107058852 | Granular cell tumor immunophenotype | S-100, vimentin, CD68 positive CK and desmin negative | 12 | |
| 5107079818 | Acinic cell carcinoma (salivary gland) | - Granules of zymogen - PAS/diastase positive - CK7, A1AT, and amylase positive - CD117 and myoep markers negative |  | 13 |
| 5107109801 | Nasopharyngeal carcinoma | - Undifferentiated tumor with syncytial sheets of cells with large nuclei and nucleoli and numerous lymphocytes - EBV associated, common in asia |  | 14 |
| 5107131801 | Olfactory neuroblastoma | - dumbbell-shaped tumor straddling the cribriform plate | 15 | |
| 5107148718 | Choriocarcinoma |  | 16 | |
| 5107156543 | Chorangioma of placenta |  | 17 | |
| 5107163145 | dysgerminoma | Most common malignant germ cell tumor of the ovary |  | 18 |
| 5107170682 | - CK7, CA-125, CEA, EMA, and WT-1 positive | Ovarian Brenner tumor immunophenotype | 19 | |
| 5107174630 | Leydig cell tumor |  | 20 | |
| 5107187709 | Ovarian stromal carcinoid | - combination of stuma ovarii and carcinoid tumor | 21 | |
| 5107194093 | AFP and CA-125 | serum markers for yold sac tumor | 22 | |
| 5107196787 | Yolk sac tumor |  | 23 | |
| 5107210401 | - solitary submucosal lesions in the myometrium or endometrium - stain with smooth muscle markers | Plexiform tumorlet | 24 | |
| 5107220830 | Other name for malignant mixed mullerian tumor | carcinosarcoma | 25 | |
| 5107608489 | Adenomatoid tumor | - Benign tumor of ovarian/testicular adnexa - Derived from mesothelial cells and stains as such |  | 26 |
| 5107622746 | Grade I: less than 5% solid growth Grade II: 5-50% solid growth Grade III: >50% solid | Grading of endometrioid endometrial adenocarcinoma | 27 | |
| 5107647929 | Mesonephric adenocarcinoma | - Rare tumor originating from mesonephric remnants - Wall of cervix - Compact growth of small tubules - EMA, vimentin, calretinin, CD10 and LMWK are positive - CEA ER/PR negative | 28 | |
| 5107656579 | Aggressive angiomyxoma | - infiltrative but non-metastasizing lesion of the perineal region - Myxoid matrix with bland spindle cells and hyalinized vessels with surrounding collagen - Desmin, SMA, ER/PR positive |  | 29 |
| 5107683029 | Papillary hiradenoma | - nodule in perineal area in women - double layer - epithelial and myoepithelial - occasionally becomes malignant |  | 30 |
| 5107883897 | - SMA and vimentin positive - CD31, FVIII, and CK negative | PASH immunophenotype | 31 | |
| 5107897056 | Breast carcinoma with medullary features | - Better prog than IDC NOS' - >75% syncytial growth and high mitotic rate - Brisk lymphoplasmacytic response - Well-circumscribed borders - Usually triple negative | 32 | |
| 5108457183 | Mesoblastic nephroma | - Most common congenital renal neoplasm - firm, whorled cut surface - Fibromatosis-like appearance |  | 33 |
| 5108465277 | Multilocular cystic RCC | - EMA, CAM5.2, vimentin, PAX-8, and CD10 positive |  | 34 |
| 5108477239 | CD117, OCT 3/4, PLAP positive | Seminoma immunophenotype | 35 | |
| 5108484351 | Myelolipoma - benign lesion usually in the adrenal gland - 80% have X chromosome inactivation |  | 36 | |
| 5108495145 | HMB-45, Melan-A, SMA, and desmin positive | Angiomyolipoma immunophenotype | 37 | |
| 5108500207 | Sertoli cell tumor - 10% malignant - CK, vimentin, inhibin positive - Patterns include tubular, cords, sheets, or aggregates | Gonadal tumor |  | 38 |
| 5108543233 | Translocation RCC - Xp11.2 translocation, corresponds to TFE3 positivity by IHC - Young adults, mixture of patterns (clear, papillary, etc) often with psammoma bodies | Renal tumor |  | 39 |
| 5108556339 | PLAP, CD30, EMA positive | Embryonal carcinoma immunophenotype | 40 | |
| 5108564259 | Collecting duct carcinoma - cords, tubules, etc in a desmoplastic stroma - intracytoplasmic mucin - high mitotic rate - poor prognosis | Kidney |  | 41 |
| 5108580186 | Gonadoblastoma -Mixed germ cell and sex cord stromal tumor - 80% phenotypically female but 46, XY - nests of germ cells and sex cord stromal cells with hyaline basement membrane material - Germ cells are PLAP and CD117 positive, sex cord stromal cells are inhibin positive | Pelvic tumor |  | 42 |
| 5108593952 | Lymphangioleiomyomatosis - Occurs in lungs of young women; linked to tuberous sclerosis genes - resembles angiomyolipoma - spindle proliferation with lymphoid tissue. | Lung nodule |  | 43 |
| 5132184003 | - Insular pattern due to expanded sinuses | Lymphoplasmacytic lymphoma | 44 | |
| 5132293253 | - necrosis with neutrophils - granulomas - warthin-starry | Cat scratch disease | 45 | |
| 5132364045 | - Infiltration of red pulp, with atrophy of white pulp - Intermediate cells with pale cytoplasm, loose chromatin - CD2, CD3, CD7 positive - Usually both CD4 and CD8 negative | Hepatosplenic T cell lymphoma | 46 | |
| 5132492285 | - Oral cavity, HIV pts - CD45 often negative, CD20 negative, CD79a positive, CD138 positive - High ki-67, 50% EBV positive - Blastic high-grade morphology | Plasmablastic lymphoma | 47 | |
| 5132601541 | - ALK + - CD30 + - Hallmark cells (horseshoe nuclei) | Anaplastic large cell lymphoma | 48 | |
| 5132944133 | - Partial effacement of node with distension of sinuses by Langerhans cells - abundant, pale eosinophilic cytoplasm, irregular and elongated nuclei with prominent nuclear grooves and folds, fine chromatin and indistinct nucleoli - Occasionally multinucleated - Sinuses commonly have foci of necrosis, often surrounded by rim of eosinophils | Langerhans histiocytosis (systemic/nodal) | 49 | |
| 5133248554 | rosai dorfman - sinus histiocytosis with massive lymphadenopathy - can also occur in extranodal tissues | Enlarged lymph node |  | 50 |
| 5133309489 | - poorly formed granulomas, especially near or within germinal centers - Follicular hyperplasia with frequent tangible body macrophages - Interfollicular monocytoid B cells | Toxoplasmosis (LN) | 51 | |
| 5133372789 | mucinous cystic neoplasm |  | 52 | |
| 5133586070 | lymphoepithelial cyst | Pancreas, salivary gland, or neck |  | 53 |
| 5133649693 | basal cell adenoma - resembles pleomorphic adenoma or adenoid cystic carcinoma (sometimes) but has peripheral palisading. | salivary gland |  | 54 |
| 5133724180 | Mucoepidermoid carcinoma - will see areas of squamoid epithelium as well as mucinous epithelium. - DDx includes adenosquamous carcinoma, which will have anaplastic features | Salivary gland |  | 55 |
| 5133753024 | - Biphasic epithelial and mesenchymal - Stroma may be myxoid, hyaline, chondroid, rarely adipose tissue or osseous; mucin often present - No mucinous epithelium (vs. mucoep carc.) | Pleomorphic adenoma | 56 | |
| 5133908989 | - Not a specific type of carcinoma - often adenocarcinoma NOS, myoepithelial, salivary duct, terminal duct or undifferentiated carcinomas - Abrupt transition from the PA | Carcinoma ex pleomorphic adenoma | 57 | |
| 5134234080 | acinic cell carcinoma | Salivary gland | | 58 |
| 5134432881 | Hyaline trabecular tumor - cytoplasm contains yellow, paranuclear cytoplasmic inclusions with clear halo of retracted cytoplasm and nuclear molding - trabecular or organoid appearance - hyaline material in extracellular spaces - may see psammoma bodies | Thyroid gland |  | 59 |