Pineda Chapter 14?: ?Environmental Health and Toxicology? Lecture Outline I. Central Case: Alligators and Endocrine Disruptors at Lake Apopka, Florida A. In 1985, Louis Guillette discovered bizarre reproductive problems in American alligators in Lake Apopka. B. He developed the hypothesis that certain chemical contaminants in Lake Apopka were disrupting the endocrine system of alligators during development in the egg. C. Guillette and his co-workers found that Lake Apopka alligators had abnormally low hatchling rates starting in the years after a pesticide spill. The lake also received high levels of chemical runoff from agriculture. D. Guillette?s results showed that atrazine and nitrates act as endocrine