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Journal of the Neurological Sciences 180 (2000) 52?54 www.elsevier.com/ locate / jns Beneficial effect of ginseng root in SOD-1 (G93A) transgenic mice *F. Jiang, S. DeSilva, J. Turnbull McMaster University Medical Centre, Rm 4U7, 1200 Main St W, Hamilton, Ontario, Canada L8N 3Z5 Abstract Many patients with amyotrophic lateral sclerosis (ALS; motor neuron disease) use natural or traditional therapies of unproven benefit. One such therapy is ginseng root. However, in some other disease models, ginseng has proven efficacious. Ginseng improves learning and memory in rats, and reduces neuronal death following transient cerebral ischemia. These effects of ginseng have been related to increases

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