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B12 Pharm Contraceptives Flashcards

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8155592007What's the MOA of *progestins* as contraceptives?1. *Thicken cervical mucus* 2. Endometrial atrophy 3. Block LH surge (inhibit ovulation)0
8155592008What'a really effective way to *suppress ovulation*?IM Medroxyprogesterone1
8155592009What are the *progestin* drugs, again?Norethinrone + ones with *-gest*2
8155592010What's the MOA of *estrogens* as contraceptives?Suppression of FSH release form pituitary (assists in preventing LH surge & ovulation)3
8155592011*Ethinyl estradiol* is a(n) _____________.Synthetic estrogen4
8155592012*Mestranol * is a(n) _____________.Synthetic estrogen5
8155592013*Estradiol valerate* is a(n) _____________.Synthetic estrogen6
8155592014*Norethindrone* is a(n) _____________.Progestin7
8155592015*Norgestrel* is a(n) _____________.Progestin8
8155592016*Levonorgestrel * is a(n) _____________.Progestin9
8155592017*Drospirenone * is a(n) _____________.Progestin (Mineralocorticoid blocker, like spironolactone)10
8155592018*Norelgestromin* is a(n) _____________.Progestin11
8155592019*Etonogestrel* is a(n) _____________.Progestin12
8155592020What *progestin* is given as an *IM injection*?Medroxyprogesterone13
8155592021What *progestin* is a *testosterone derivative*?Norethindrone (*Drone* for testoster*one*)14
8155592022Which *progestin* is given as an *implant*?Norgestrel15
8155592023What *progestin* is given as an *IUD*?Levonorgestrel (*Levo-*tates within the uterus)16
8155592024What *progestin* is given as a *patch*?Norelgestromin (Stroma is like skin, patch goes on the skin)17
8155592025What *progestin* is given as a *vaginal ring* OR as an *implant*?Etonogestrel (Et tu... globe theatre... circle... ring... yea)18
8155592026Which ones lasts longer— *Medroxyprogesterone or Etonogestrel*?Etonogestrel. It lasts 3 years. Medroxyprogesterone lasts 3 mos.19
8155592027How is *norethindrone* given?Orally20
8155592028A BC pill has a *fixed amount* of estrogen and progestin taken for 21 days. What kind of regimen in this?Monophasic21
8155592029A BC pill has a *2-3 different pills with varying amount* of estrogen and progestin taken for 21 days. What kind of regimen in this?Biphasic or triphasic22
8155592030What dose usually gets changed in a *biphasic or triphasic* combined oral contraceptive?Progestin gets increased. Estrogen stays the same.23
8155592031Who isn't allowed to take *combined oral contraceptives*?Women > 35 who smoke ≥ 15 cigs/day24
8155592032What can a *Woman older than 35* that *smokes 16 cigs/day* take for oral contraception?Progestin only preparations25
8155592033What's the *CV side effect* of oral contraceptives?Thromboembolism26
8155592034What is it about *COC* that increases the risk of *thromboembolism*?Estrogen increases factor VII, X, and fibrinogen production27
8155592035So, *COC* have a risk of *thromboembolism*. What contraception *does not have this risk*?Progestin only preparations28
8155592036What's a *side effect* mainly seen with *norethindrone*?Hirsutism & acne (Since it's a testosterone derivative & all)29
8155592037What contraceptive is *derived from spironolactone*?Drosperinone30
8155592038What are the *side effects* of *Drospirenone*?Anti-aldosterone & anti-androgenic effects (It's a mineralocorticoid antagonist, remember?)31
8155592039What's a *nice side effect* of *COC* use?50% decrease in endometrial cancer incidence32
8155592040What's an annoying *side effect* of *progestin-only contraception*?Irregular, unpredictable spotting and bleeding33
8155592041What determines the amount of *estrogen* given in a *COC* starting out?Weight34
8155592042What ~specific~ thing do we need to consider when choosing a *contraceptive preparation*? Why?19-norprogestin; may have ~androgenic activity~35
8155592043What's the difference between *COC & transdermal patch*, as far as blood levels go?Estrogen can be higher due to skipping first-pass metabolism when using a transdermal patch36
8160081849Can a *transdermal patch* be as effective as *COCs* in patients under 90kg?yep37
8160112766What are the two rare things patients complain about with a *vaginal ring*?Discomfort. Or worse... expelled38
8160186156What *two drugs* are typically contained in a *vaginal ring*?Ethinyl Estradiol & etonogestrel39
8160422363A mom has just had a baby. She wants to know when she can start taking her BC again. Why are we concerned about *postpartum patients using estrogen-containing COCs*?Hypercoagulability & effects on lactation40
8160432110A mom has just had a baby. She wants to know when she can start taking her BC again. When can she *start back on her estrogen-containing COCs*? What can she take in the meantime?After the first 21 days postpartum; Progestin-only contraceptives41
8160477378A breastfeeding mom has just had a baby. She has *risk factors for venous thromboembolism.* She wants to know when she can start taking her COCs again. When can she take it?After 42 days postpartum42
8160562566A breastfeeding mom has just had a baby. She has *NO risk factors for venous thromboembolism.* She wants to know when she can start taking her COCs again. When can she take it?30 days (?)43
8160618211What drugs are used as *postcoital contraceptives*?Progestin, estrogen, or combined44
8160624955What's the advantage of using a *progestin-only postcoital contraceptive*?Fewer side effects45
8160641189A woman takes a *postcoital contraceptive* 6 days after to prevent pregnancy. Is she going to be pregnant or nah?Oh, she's pregnant. Gotta take that within 72 hrs (implantation is 5 days later)46
8160661930What are the two drugs approved as *emergency contraception*?Levonorgestrel & Norgestrel47

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