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AP Biology Chapter 12: The Cell Cycle

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44012092cell divisionthe reproduction of cells, continues life
44012093cell cyclethe life of a cell from the time it is first formed from a dividing parent cell until its own division into two cells
44012094genomea cells endowment of DNA, its genetic material
44012095chromosomesDNA molecules are packed into these, makes the replication and distribution of DNA manageable
44012096somatic cellsany body cells except the reproductive cells. each contain 46 chromosomes made up of two sets of 23, one from each parent
44012097gametesreproductive cells, sperm and egg. have half as many chromosomes as somatic cells. they have one set of 23.
44012098chromatinwhat eukaryotic chromosomes are made of. complex DNA and associated protein molecules.
44012099sister chromatidseach duplicated chromosome has two of these. the two chromatids, each containing an identical DNA molecule, are initially attached by adhesive proteins along their lengths
44012100centromerethe narrow "waist" region where the two chromatids are most closely attached
44012101mitosisthe division of the nucleus
44012102cytokinesisthe division of the cytoplasm
44012103meiosisthe production cycle of gametes, yields nonidentical daughter cells that have only one set of chromosomes, thus half as many chromosomes as the parent cell. occurs in gonads
44012104mitotic (M) phasemitosis and cytokinesis, the shortest part of the cell cycle
44012105interphasealternates with the mitotic phase, accounts for 90 percent of the cell cycle. the cell grows and copies its chromosomes in preparation for cell division. divided into 3 phases: G1, S, G2
44012106G1 phasefirst gap of interphase, cell grows by producing proteins and cytoplasmic organelles such as the mitocondria and er, copies chromosomes
44012107S (synthesis) phasechromosomes are duplicated during this plase, continues growth
44012108G2 phasesecond gap. grows more as it completes preparation for cell division
44012109mitotic spindlebegins to form in the cytoplasm during prophase. this structure consists of fibers made of microtubules and associated proteins
44012110centrosomewhere assembly of spindle microtubules starts, a nonmembraneous organelle that functions throughout the cell to organize the cell's microtubules
44012111astera radical array of short microtubules, extends from each centrosome. the spindle includes the centrosomes, the spindle microtubules, and this
44012112kinetochorea structure of protiens associated with specific sections of chromosomal DNA at the centromere. each of the two sister chromatids has this
44012113G2 of Interphase-a nuclear envelope bounds the nucleus
44012114G2 of Interphase-the nucleus contains one or more nucleoli
44012115G2 of Interphase-in animal cells, each centrosome features two centrioles
44012116G2 of Interphase-chromosomes, duplicated during S phase, cannot be see individually because they have not yet condensed
44012117Prophase-the chromatin fibers become more tightly coiled, condensing into discrete chromosomes observable with a light microscope
44012118prophase-the nucleoli dissapear
44012119prophase-each duplicated chromosome appears as two identical sister chromatids joined together
44012120prophase-the mitiotic spindle begins to form. it is composed of the centrosomes and the microtubules that extend from them. the radial arrays of shorter microtubules that extend from the centrosomes are asters
44012121prophase-the centrosomes move away from each other, apparently propelled by the lengthening microtubules between them
44012122prometaphase-the nuclear envelope fragments
44012123prometaphase-the microtubules of the spindle can now invade the nuclear area and interact with the chromosomes, which have become even more condensed
44012124prometaphase-microtubules extend from each chromosome toward the middle of the cell
44012125prometaphase-each of the two chromatids of a chromosome now has a kinetochore, a specialized protein structure located at the centromere
44012126prometaphase-some of the microtubules attach to the kinetochores, becoming "kinetochore microtubules" these jerk the chromosomes back and forth
44012127prometaphase-nonkinetochore microtubules interact with those from the opposite pole of the spindle
44012128metaphase-the longest stage of mitoisis lasting 20 minutes
44012129metaphase-the centrosomes are now at opposite ends of the cell
44012130metaphase-the chromosomes convene on the metaphase plate, an imaginary plane that is equidistant between the spindles two poles. the chromosomes cetromeres lie on the metaphase plate.
44012131metaphase-for each chromosome, the kinetochores of the sister chromatids are attached to kinetochore microtubules coming from opposite poles
44012132metaphase-the entire apparatus of microtubules is called the spindle because of its shape
44012133anaphasethe shortest stage of mitosis, lasting only a few minutes
44012134anaphasebegins when the two sister chromatids of each pair suddenly part. each chromatid this becomes a full fledged chromosome
44012135anaphase-the two liberated chromosomes begin moving toward opposite ends of the cell, as their kinetochore microtubules shorten. because these microtubules are attached at the centromere region, the chromosomes move centromere first.
44012136anaphase-the cell elongates as the nonkinetochore microtubules tighten
44012137anaphase-by the end of this stage, the two ends of the cell have equivilent and complete collections of chromosomes
44012138telophase-two daughter nuclei begin to form in the cell
44012139telophase-nuclear evelopes arise from the fragments of the parent cell's nuclear evelope and other portions of the endomembrane system
44012140telophase-the chromosomes are less condensed
44012141telophase-mitosis, the division of one nucleus into two genetically identical nuclei, is now complete
44012142cytokinesis-the division of the cytoplasm is usually well underway by late telophase, so that the two daughter cells appear shortly after the end of mitosis
44012143cytokinesis-in animal cells, cytokinesis involves the formation of a cleavage furrow, which pinches the cell in two
44012144origin of replicationthe specific place the chromosome begins to replicate
44012145cell cycle control systemcyclically operating set of molecules in the cell that both triggers and coordinates key events in the cell cycle.
44012146checkpointin the cell cycle, a critical control point where a stop and go ahead signal is given regulates the cycle. usuallyif it passes G1 it goes all the way, baby
44012147G0 phaseif it does not recieve a go ahead signal at that point, it will exit the cycle, switching into a nondividing state. most cells in the human body are in this phase.
44012148cyclinin order for the kinase that drives the cell cycle to actually be active in the cell, it must be attached to one of these. this cyclically fluctuates at a concentration in the cell
44012149cyclin dependent kinasescdks. activity of these rise and falls with the level of the cyclin partner
44012150growth factora protein released by certain cells that stimulates other cells to divide. mitogen
44012151density-dependent inhibitionwhen crowded cells stop dividing. the amount of growth factors provided are the main factor to determine this
44012152anchorage dependenceexhibited by most animal cells. to divide, cells must be attached to a substratum such as the inside ofa culutre jar, or the extracellular matrix
44012153metastasisthe spread of cancer cells to locations distant from their original site

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