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AP Biology Chapter 16 Flashcards

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8568883463DNA Replicationthe process by which a DNA molecule is copied; also called DNA synthesis0
8568883464Transformationa change in genotype and phenotype due to the assimilation of external DNA by a cell transforming substance- DNA1
8568883465BacteriophagesViruses that infect bacteria Bacteria eaters2
8568883466Virusinfects a cell and takes over the cell's metabolic machinery3
8568883467Hershey and ChaseConcluded that phage DNA entered bacterial host cells, but phage proteins did not, so DNA functions as the genetic material4
8568883468GriffithConcluded that nonpathogenic bacteria transformed into pathogenic bacteria by an unknown, heritable substance from the dead S cells that enabled the R cells to make capsules5
8568883469Chargaff's Lawthe base compostion of DNA varies between species and for each species, the percentages of A and T bases are roughly equal to the percentages of the G and C bases6
8568883470Rosalind Franklinaccomplished X-ray crystallographer that discovered the double helix of DNA7
8568883471Antiparallelsubunits run in opposite directions8
8568883472Nitrogenous bases of DnaA, T, C, G9
8568883473PurinesA and G Nitrogenous bases with two organic rings10
8568883474PyrimidinesC and T Nitrogenous base with a single organic ring11
8568883476Semiconservative Modelthe two strands of the parental molecule separate and each functions as a template for synthesis of a new complementary strand- most common12
8568883478Origins of Replicationshort stretches of DNA having a specific sequence of nucleotides13
8568883479Replication Forka Y shaped region where the parental strands of DNA are being unwound14
8568883480Helicasesenzymes that untwist the double helix at the replication forks, separating the two parental strands and make them available as template strands15
8568883482TopoisomeraseThe untwisting of double helix causes tighter twisting and strain ahead of replication fork Relieve this strain by breaking swiveling, and rejoining DNA strands16
8568883483PrimerThe initial nucleotide chain that is produced during DNA synthesis is actually a short stretch of RNA17
8568883484PrimaseSynthesizes the primer Starts a complementary RNA chain from a single RNA nucleotide, adding more RNA nucleotides one at a time, using the parental DNA strand as a template18
8568883485DNA polymerasesEnzyme that catalyze the synthesis of new DNA by adding nucleotides to a preexisting chain19
8568883486Leading strandStrand that continuously adds nucleotides to the new complementary strand as the fork progresses DNA pol III20
8568883487Lagging StrandThe strand that DNA pol III works away from the replication fork Synthesized discontinuosly as a series of segments21
8568883488Okazaki fragmentsSeries of segments that are 1000-2000 nucleotides long22
8568883489DNA Ligasejoins the sugar phosphate backbones of all the Okazaki fragments into a continuous DNA strand23
8568883490DNA pol IIISynthesizes new DNA strands by adding nucleotides to an RNA primer or a pre-existing DNA strand24
8568883491DNA pol IRemoves RNA nucleotides of primer from 5' end and replaces them with DNA nucleotides25
8568883492Mismatch repairOther enzymes remove and replace incorrectly paired nucleotides that have resulted from replication errors26
8568883493NucleaseDNA cutting enzyme that cuts out the damaged parts of the strand and fills the space with nucleotides using the undamaged strand as a template27
8568883494Nucleotide excision repairDNA repair system where teams of enzymes detect and repair the DNA, the nuclease cuts out the damaged DNA and removes it, fills in the missing nucleotides and the DNA ligase seals the free end of the new DNA to the old DNA making the strand complete28
8568883495TelomeresSpecial nucleotide sequences at the ends of chromosomes TTAGGG is repeated between 100-1000 times Prevent the staggered ends of daughter molecule from activitating cell's system for monitoring DNA damage29
8568883496TelomeraseEnzyme that catalyzes the lengthening of telomeres in eukaryotic germ cells and restores the original length and compensating for the shortening that occurs during DNA replication30
8568883497HistonesProteins that are responsible for the first level of DNA packing in chromatin31
8568883498Nucleosomethe basic unit of DNA packing32

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