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AP Biology Chapter 16 Flashcards

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8679915659DNA Replicationthe process by which a DNA molecule is copied; also called DNA synthesis0
8679915660Transformationa change in genotype and phenotype due to the assimilation of external DNA by a cell transforming substance- DNA1
8679915661BacteriophagesViruses that infect bacteria Bacteria eaters2
8679915662Virusinfects a cell and takes over the cell's metabolic machinery3
8679915663Hershey and Chase (Don't need to memorize scientists)Concluded that phage DNA entered bacterial host cells, but phage proteins did not, so DNA functions as the genetic material4
8679915664Griffith (Don't need to memorize scientists)Concluded that nonpathogenic bacteria transformed into pathogenic bacteria by an unknown, heritable substance from the dead S cells that enabled the R cells to make capsules5
8679915665Chargaff's Lawthe base compostion of DNA varies between species and for each species, the percentages of A and T bases are roughly equal to the percentages of the G and C bases6
8679915666Rosalind Franklin (Don't need to memorize scientists)accomplished X-ray crystallographer that discovered the double helix of DNA7
8679915667Antiparallelsubunits run in opposite directions8
8679915668Nitrogenous bases of DnaA, T, C, G9
8679915669PurinesA and G Nitrogenous bases with two organic rings10
8679915670PyrimidinesC and T Nitrogenous base with a single organic ring11
8679915671Conservative modeltwo parental strands reassociate after acting as templates for new strands thus restoring the parental double helix12
8679915672Semiconservative Modelthe two strands of the parental molecule separate and each functions as a template for synthesis of a new complementary strand- most common13
8679915673Dispersive Modeleach strand of both daughter molecules contains a mixture of old and newly synthesized DNA14
8679915674Origins of Replicationshort stretches of DNA having a specific sequence of nucleotides15
8679915675Replication Forka Y shaped region where the parental strands of DNA are being unwound16
8679915676Helicasesenzymes that untwist the double helix at the replication forks, separating the two parental strands and make them available as template strands17
8679915677Single Strand Binding ProteinsBind to the unpaired DNA strands keeping them from repairing18
8679915678TopoisomeraseThe untwisting of double helix causes tighter twisting and strain ahead of replication fork Relieve this strain by breaking swiveling, and rejoining DNA strands19
8679915679PrimerThe initial nucleotide chain that is produced during DNA synthesis is actually a short stretch of RNA20
8679915680PrimaseSynthesizes the primer Starts a complementary RNA chain from a single RNA nucleotide, adding more RNA nucleotides one at a time, using the parental DNA strand as a template21
8679915681DNA polymerasesEnzyme that catalyze the synthesis of new DNA by adding nucleotides to a preexisting chain22
8679915682Leading strandStrand that continuously adds nucleotides to the new complementary strand as the fork progresses DNA pol III23
8679915683Lagging StrandThe strand that DNA pol III works away from the replication fork Synthesized discontinuosly as a series of segments24
8679915684Okazaki fragmentsSeries of segments that are 1000-2000 nucleotides long25
8679915685DNA Ligasejoins the sugar phosphate backbones of all the Okazaki fragments into a continuous DNA strand26
8679915686DNA pol IIISynthesizes new DNA strands by adding nucleotides to an RNA primer or a pre-existing DNA strand27
8679915687DNA pol IRemoves RNA nucleotides of primer from 5' end and replaces them with DNA nucleotides28
8679915688Mismatch repairOther enzymes remove and replace incorrectly paired nucleotides that have resulted from replication errors29
8679915689NucleaseDNA cutting enzyme that cuts out the damaged parts of the strand and fills the space with nucleotides using the undamaged strand as a template30
8679915690Nucleotide excision repairDNA repair system where teams of enzymes detect and repair the DNA, the nuclease cuts out the damaged DNA and removes it, fills in the missing nucleotides and the DNA ligase seals the free end of the new DNA to the old DNA making the strand complete31
8679915691TelomeresSpecial nucleotide sequences at the ends of chromosomes TTAGGG is repeated between 100-1000 times Prevent the staggered ends of daughter molecule from activitating cell's system for monitoring DNA damage32
8679915692TelomeraseEnzyme that catalyzes the lengthening of telomeres in eukaryotic germ cells and restores the original length and compensating for the shortening that occurs during DNA replication33
8679915693HistonesProteins that are responsible for the first level of DNA packing in chromatin34
8679915694Nucleosomethe basic unit of DNA packing35
8679915695Chromatincomplex of DNA and protein36
8679915696Heterochromatincentromeres and telomeres exist in a highly condensed state with visible irregular clumps making it largely inaccessible37
8679915697Euchromatincentromeres and telomeres exist in a less compacted state that is very accessible ("true chromatin")38

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