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AP Biology Chapter 16 Flashcards

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8556810480DNA Replicationthe process by which a DNA molecule is copied; also called DNA synthesis0
8556810481Transformationa change in genotype and phenotype due to the assimilation of external DNA by a cell transforming substance- DNA1
8556810482BacteriophagesViruses that infect bacteria Bacteria eaters2
8556810483Virusinfects a cell and takes over the cell's metabolic machinery3
8556810484Hershey and ChaseConcluded that phage DNA entered bacterial host cells, but phage proteins did not, so DNA functions as the genetic material4
8556810485GriffithConcluded that nonpathogenic bacteria transformed into pathogenic bacteria by an unknown, heritable substance from the dead S cells that enabled the R cells to make capsules5
8556810486Chargaff's Lawthe base compostion of DNA varies between species and for each species, the percentages of A and T bases are roughly equal to the percentages of the G and C bases6
8556810487Rosalind Franklinaccomplished X-ray crystallographer that discovered the double helix of DNA7
8556810488Antiparallelsubunits run in opposite directions8
8556810489Nitrogenous bases of DNAA, T, C, G9
8556810490PurinesA and G Nitrogenous bases with two organic rings10
8556810491PyrimidinesC and T Nitrogenous base with a single organic ring11
8556810492Conservative modeltwo parental strands reassociate after acting as templates for new strands thus restoring the parental double helix12
8556810493Semiconservative Modelthe two strands of the parental molecule separate and each functions as a template for synthesis of a new complementary strand- most common13
8556810494Dispersive Modeleach strand of both daughter molecules contains a mixture of old and newly synthesized DNA14
8556810495Origins of Replicationshort stretches of DNA having a specific sequence of nucleotides15
8556810496Replication Forka Y shaped region where the parental strands of DNA are being unwound16
8556810497Helicasesenzymes that untwist the double helix at the replication forks, separating the two parental strands and make them available as template strands17
8556810498Single Strand Binding ProteinsBind to the unpaired DNA strands keeping them from repairing18
8556810499TopoisomeraseThe untwisting of double helix causes tighter twisting and strain ahead of replication fork Relieve this strain by breaking swiveling, and rejoining DNA strands19
8556810500PrimerThe initial nucleotide chain that is produced during DNA synthesis is actually a short stretch of RNA20
8556810501PrimaseSynthesizes the primer Starts a complementary RNA chain from a single RNA nucleotide, adding more RNA nucleotides one at a time, using the parental DNA strand as a template21
8556810502DNA polymerasesEnzyme that catalyze the synthesis of new DNA by adding nucleotides to a preexisting chain22
8556810503Leading strandStrand that continuously adds nucleotides to the new complementary strand as the fork progresses DNA pol III23
8556810504Lagging StrandThe strand that DNA pol III works away from the replication fork Synthesized discontinuosly as a series of segments24
8556810505Okazaki fragmentsSeries of segments that are 1000-2000 nucleotides long25
8556810506DNA Ligasejoins the sugar phosphate backbones of all the Okazaki fragments into a continuous DNA strand26
8556810507DNA pol IIISynthesizes new DNA strands by adding nucleotides to an RNA primer or a pre-existing DNA strand27
8556810508DNA pol IRemoves RNA nucleotides of primer from 5' end and replaces them with DNA nucleotides28
8556810509Mismatch repairOther enzymes remove and replace incorrectly paired nucleotides that have resulted from replication errors29
8556810510NucleaseDNA cutting enzyme that cuts out the damaged parts of the strand and fills the space with nucleotides using the undamaged strand as a template30
8556810511Nucleotide excision repairDNA repair system where teams of enzymes detect and repair the DNA, the nuclease cuts out the damaged DNA and removes it, fills in the missing nucleotides and the DNA ligase seals the free end of the new DNA to the old DNA making the strand complete31
8556810512TelomeresSpecial nucleotide sequences at the ends of chromosomes TTAGGG is repeated between 100-1000 times Prevent the staggered ends of daughter molecule from activitating cell's system for monitoring DNA damage32
8556810513TelomeraseEnzyme that catalyzes the lengthening of telomeres in eukaryotic germ cells and restores the original length and compensating for the shortening that occurs during DNA replication33
8556810514HistonesProteins that are responsible for the first level of DNA packing in chromatin34
8556810515Nucleosomethe basic unit of DNA packing35
8556810516Chromatincomplex of DNA and protein36
8556810517Heterochromatincentromeres and telomeres exist in a highly condensed state with visible irregular clumps making it largely inaccessible37
8556810518Euchromatincentromeres and telomeres exist in a less compacted state that is very accessible38

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