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AP Biology: Chapter 18 (gene expression) Flashcards

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8525528494Operator-off/on "switch" that controls whole cluster of functionally related genes0
8525528495Operon-operate + promoter + genes they control -entire stretch of DNA for enzyme production for tryptophan pathway1
8525528496Repressor-protein that switches operon off2
8525528497Regulatory Gene (trpR)-product of trp repressor3
8525528498Corepressorsmall molecule that cooperates w/ repressor protein to switch operon off4
8525528499Repressible Operontranscription usually on but can be inhibited when specific small molecule binds allosterically to regulatory protein5
8525528500Inducible Operontranscription usually off but can be stimulated when specific small molecule interacts w/ regulatory protein6
8525528501Inducerspecific small molecule, inactivates repressor7
8525528502Activatorprotein that binds to DNA and stimulates gene transcription (ex. CAP)8
8525528503Differential Gene Expressionexpression of different genes by cells in the same genome9
8525528504Histone Acetylation-attached to lysines in histone tails -> lysines acetylated -> positive charges neutralized -histone tails no longer bind to neighboring nucleosomes10
8525528505Control Elementssegments of noncoding DNA that help regulate transcription by binding certain proteins11
8525528506Enhancers-distal control elements -may be thousands of nucleotides upstream/downstream of gene or in intron12
8525528507Alternative RNA Splicing-different mRNA molecules produced from same primary transcript, depending on which RNA segments are treated as introns and exons -can expand repertoire of eukaryotic genome13
8525528508Proteasomegiant protein complex recognize ubiquitin-tagged proteins and degradation14
8525528509microRNAs (miRNAs)-small, single-stranded RNA molecules capable of binding to complementary sequences in mRNA molecules15
8525528510RNA interference (RNAi)injecting double-stranded RNA molecules into cell turned off expression of gene w/ same sequence as RNA16
8525528511Small Interfering RNAs (siRNAs)-similar in size and function to miRNAs -formed by much longer double-stranded RnA molecules -> many siRNAs17
8525528512Cell Differentiationprocess by which cells become specialized in structure and function18
8525528513Morphogenesisphysical processes that give organism its shape19
8525528514Cytoplasmic Determinantsmaternal substances in egg that influence course of early development20
8525528515Inductionchanges in target cells caused by signals impinging on embryonic cell from others in vicinity, including contact w/ cell surface molecules on neighboring cells and binding of growth factors secreted by neighboring cells21
8525528516Determination-events that lead to observable differentiation of cell22
8525528517Homoeotic Genescontrol pattern formation in late embryo, larva, and adult23
8525528518Bicoid (two-tailed)-mutant gene causes lack of front half of body and posterior structure at both ends -essential for setting anterior end24
8525528519Morphagengradients for substances that establish embryos axis and more25
8525528520Oncogenes-cancer-causing genes26
8525528521Proto-Oncogenes-normal versions of cellular genes -code for proteins that stimulate normal cell growth and division27
8525528522Tumor-Supressor Genes-prevent uncontrolled cell growth -repair damaged DNA -control cell anchorage (absent in cancers)28
8525528523Ras ProteinG protein that relays signal from growth factor on plasma membrane29
8525528524p53tumor suppressor gene that codes for specific transcription factor protein that promotes synthesis of cell cycle30
8525528525Mutation Effects-result in cell cycle overstimulated -not inhibited normally31

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