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AP Biology DNA Flashcards

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6051756018DNA Replicationthe process by which a DNA molecule is copied; also called DNA synthesis0
6051756019Transformationa change in genotype and phenotype due to the assimilation of external DNA by a cell transforming substance- DNA1
6051756020BacteriophagesViruses that infect bacteria Bacteria eaters2
6051756021Virusinfects a cell and takes over the cell's metabolic machinery3
6051756022Hershey and Chase (Don't need to memorize scientists)Concluded that phage DNA entered bacterial host cells, but phage proteins did not, so DNA functions as the genetic material4
6051756023Griffith (Don't need to memorize scientists)Concluded that nonpathogenic bacteria transformed into pathogenic bacteria by an unknown, heritable substance from the dead S cells that enabled the R cells to make capsules5
6051756024Chargaff's Lawthe base compostion of DNA varies between species and for each species, the percentages of A and T bases are roughly equal to the percentages of the G and C bases6
6051756025Rosalind Franklin (Don't need to memorize scientists)accomplished X-ray crystallographer that discovered the double helix of DNA7
6051756026Antiparallelsubunits run in opposite directions8
6051756027Nitrogenous bases of DnaA, T, C, G9
6051756028PurinesA and G Nitrogenous bases with two organic rings10
6051756029PyrimidinesC and T Nitrogenous base with a single organic ring11
6051756030Conservative modeltwo parental strands reassociate after acting as templates for new strands thus restoring the parental double helix12
6051756031Semiconservative Modelthe two strands of the parental molecule separate and each functions as a template for synthesis of a new complementary strand- most common13
6051756032Dispersive Modeleach strand of both daughter molecules contains a mixture of old and newly synthesized DNA14
6051756033Origins of Replicationshort stretches of DNA having a specific sequence of nucleotides15
6051756034Replication Forka Y shaped region where the parental strands of DNA are being unwound16
6051756035Helicasesenzymes that untwist the double helix at the replication forks, separating the two parental strands and make them available as template strands17
6051756036Single Strand Binding ProteinsBind to the unpaired DNA strands keeping them from repairing18
6051756037TopoisomeraseThe untwisting of double helix causes tighter twisting and strain ahead of replication fork Relieve this strain by breaking swiveling, and rejoining DNA strands19
6051756038PrimerThe initial nucleotide chain that is produced during DNA synthesis is actually a short stretch of RNA20
6051756039PrimaseSynthesizes the primer Starts a complementary RNA chain from a single RNA nucleotide, adding more RNA nucleotides one at a time, using the parental DNA strand as a template21
6051756040DNA polymerasesEnzyme that catalyze the synthesis of new DNA by adding nucleotides to a preexisting chain22
6051756041Leading strandStrand that continuously adds nucleotides to the new complementary strand as the fork progresses DNA pol III23
6051756042Lagging StrandThe strand that DNA pol III works away from the replication fork Synthesized discontinuosly as a series of segments24
6051756043Okazaki fragmentsSeries of segments that are 1000-2000 nucleotides long25
6051756044DNA Ligasejoins the sugar phosphate backbones of all the Okazaki fragments into a continuous DNA strand26
6051756045DNA pol IIISynthesizes new DNA strands by adding nucleotides to an RNA primer or a pre-existing DNA strand27
6051756046DNA pol IRemoves RNA nucleotides of primer from 5' end and replaces them with DNA nucleotides28
6051756047Mismatch repairOther enzymes remove and replace incorrectly paired nucleotides that have resulted from replication errors29
6051756048NucleaseDNA cutting enzyme that cuts out the damaged parts of the strand and fills the space with nucleotides using the undamaged strand as a template30
6051756049Nucleotide excision repairDNA repair system where teams of enzymes detect and repair the DNA, the nuclease cuts out the damaged DNA and removes it, fills in the missing nucleotides and the DNA ligase seals the free end of the new DNA to the old DNA making the strand complete31
6051756050TelomeresSpecial nucleotide sequences at the ends of chromosomes TTAGGG is repeated between 100-1000 times Prevent the staggered ends of daughter molecule from activitating cell's system for monitoring DNA damage32
6051756051TelomeraseEnzyme that catalyzes the lengthening of telomeres in eukaryotic germ cells and restores the original length and compensating for the shortening that occurs during DNA replication33
6051756052HistonesProteins that are responsible for the first level of DNA packing in chromatin34
6051756053Nucleosomethe basic unit of DNA packing35
6051756054Chromatincomplex of DNA and protein36
6051756055Heterochromatincentromeres and telomeres exist in a highly condensed state with visible irregular clumps making it largely inaccessible37
6051756056Euchromatincentromeres and telomeres exist in a less compacted state that is very accessible38

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