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AP BIology DNA Replication Flashcards

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9831375650DNA Replicationprocess by which DNA molecule is copied; DNA synthesis (S stage of interphase)0
9831375651Transformationa change in genotype and phenotype due to the assimilation of external DNA by bacteria1
9831375652BacteriophagesViruses that infect bacteria Bacteria eaters2
9831375653Virusinfects a cell and takes over the cell's metabolic machinery3
9831375654Hershey and ChaseConcluded that viral DNA entered bacterial host cells, but viral proteins did not, so DNA fis the genetic material4
9831375655Chargaff's Lawthe base compostion of DNA varies between species and for each species, the percentages of A and T bases are roughly equal to the percentages of the G and C bases5
9831375656Rosalind FranklinX-ray crystallographer that discovered the double helix of DNA6
9831375657Watson and Crickdiscovered the structural double helix model of DNA7
9831375658Double helixtwo twisted strands8
9831375659Antiparallelsubunits run in opposite directions9
9831375660Nitrogenous bases of DnaA, T, C, G10
9831375661PurinesA and G Nitrogenous bases with two organic rings11
9831375662PyrimidinesC and T Nitrogenous base with a single organic ring12
9831375663Semiconservative Modelthe two strands of the parental molecule separate and each functions as a template for synthesis of a new complementary strand- most common13
9831375664Origins of Replicationshort stretches of DNA having a specific sequence of nucleotides14
9831375665Replication Forka Y shaped region where the parental strands of DNA are being unwound15
9831375666Helicasesenzymes that untwist the double helix at the replication forks, separating the two parental strands and make them available as template strands16
9831375667TopoisomeraseThe untwisting of double helix causes tighter twisting and strain ahead of replication fork Relieve this strain by breaking swiveling, and rejoining DNA strands17
9831375668Leading strandStrand that continuously adds nucleotides to the new complementary strand as the fork progresses18
9831375669Lagging StrandThe strand that DNA polymerase works away from the replication fork; Synthesized discontinuosly as a series of segments19
9831375670Okazaki fragmentsSeries of segments that are 1000-2000 nucleotides long20
9831375671DNA Ligasejoins the sugar phosphate backbones of all the Okazaki fragments into a continuous DNA strand21
9831375672DNA polymeraseSynthesizes new DNA strands by adding nucleotides to a pre-existing DNA strand22
9831375673Mismatch repairOther enzymes remove and replace incorrectly paired nucleotides that have resulted from replication errors23
9831375674NucleaseDNA cutting enzyme that cuts out the damaged parts of the strand and fills the space with nucleotides using the undamaged strand as a template24
9831375675Nucleotide excision repairDNA repair system where teams of enzymes detect and repair the DNA, the nuclease cuts out the damaged DNA and removes it, fills in the missing nucleotides and the DNA ligase seals the free end of the new DNA to the old DNA making the strand complete25
9831375676TelomeresSpecial nucleotide sequences at the ends of chromosomes TTAGGG is repeated between 100-1000 times Prevent the staggered ends of daughter molecule from activitating cell's system for monitoring DNA damage26
9831375677HistonesProteins that are responsible for the first level of DNA packing in chromatin27
9831375678Nucleosomethe basic unit of DNA packing28
9831375679Chromatincomplex of DNA and protein29
9831375680plasmidsmall circular DNA strand in the cytoplasm of a bacterium30
9831375681Avery, McCarty, McLeod experimentProtein- and RNA-degrading enzymes had little effect on transformation, but enzymes that degrade DNA eliminated the transforming activity.31
9831375683complementary32
9831375682retrovirusRNA virus; uses reverse transcriptase enzyme to produce DNA from its RNA genome33
9831375684nucleotide34

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