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AP BIology DNA Replication Flashcards

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5637182762DNA Replicationthe process by which a DNA molecule is copied; also called DNA synthesis0
5637182763Transformationa change in genotype and phenotype due to the assimilation of external DNA by a cell transforming substance- DNA1
5637182764BacteriophagesViruses that infect bacteria Bacteria eaters2
5637182765Virusinfects a cell and takes over the cell's metabolic machinery3
5637182766Hershey and ChaseConcluded that phage DNA entered bacterial host cells, but phage proteins did not, so DNA functions as the genetic material4
5637182767GriffithConcluded that nonpathogenic bacteria transformed into pathogenic bacteria by an unknown, heritable substance from the dead S cells that enabled the R cells to make capsules5
5637182768Chargaff's Lawthe base compostion of DNA varies between species and for each species, the percentages of A and T bases are roughly equal to the percentages of the G and C bases6
5637182769Rosalind Franklinaccomplished X-ray crystallographer that discovered the double helix of DNA7
5637182770Watson and CrickCame up with the structural model of DNA8
5637182771Double helixtwo strands9
5637182772Antiparallelsubunits run in opposite directions10
5637182773Nitrogenous bases of DnaA, T, C, G11
5637182774PurinesA and G Nitrogenous bases with two organic rings12
5637182775PyrimidinesC and T Nitrogenous base with a single organic ring13
5637182776Conservative modeltwo parental strands reassociate after acting as templates for new strands thus restoring the parental double helix14
5637182777Semiconservative Modelthe two strands of the parental molecule separate and each functions as a template for synthesis of a new complementary strand- most common15
5637182778Dispersive Modeleach strand of both daughter molecules contains a mixture of old and newly synthesized DNA16
5637182779Origins of Replicationshort stretches of DNA having a specific sequence of nucleotides17
5637182780Replication Forka Y shaped region where the parental strands of DNA are being unwound18
5637182781Helicasesenzymes that untwist the double helix at the replication forks, separating the two parental strands and make them available as template strands19
5637182782Single Strand Binding ProteinsBind to the unpaired DNA strands keeping them from repairing20
5637182783TopoisomeraseThe untwisting of double helix causes tighter twisting and strain ahead of replication fork Relieve this strain by breaking swiveling, and rejoining DNA strands21
5637182784PrimerThe initial nucleotide chain that is produced during DNA synthesis is actually a short stretch of RNA22
5637182785PrimaseSynthesizes the primer Starts a complementary RNA chain from a single RNA nucleotide, adding more RNA nucleotides one at a time, using the parental DNA strand as a template23
5637182786DNA polymerasesEnzyme that catalyze the synthesis of new DNA by adding nucleotides to a preexisting chain24
5637182787Leading strandStrand that continuously adds nucleotides to the new complementary strand as the fork progresses DNA pol III25
5637182788Lagging StrandThe strand that DNA pol III works away from the replication fork Synthesized discontinuosly as a series of segments26
5637182789Okazaki fragmentsSeries of segments that are 1000-2000 nucleotides long27
5637182790DNA Ligasejoins the sugar phosphate backbones of all the Okazaki fragments into a continuous DNA strand28
5637182791DNA pol IIISynthesizes new DNA strands by adding nucleotides to an RNA primer or a pre-existing DNA strand29
5637182792DNA pol IRemoves RNA nucleotides of primer from 5' end and replaces them with DNA nucleotides30
5637182793Mismatch repairOther enzymes remove and replace incorrectly paired nucleotides that have resulted from replication errors31
5637182794NucleaseDNA cutting enzyme that cuts out the damaged parts of the strand and fills the space with nucleotides using the undamaged strand as a template32
5637182795Nucleotide excision repairDNA repair system where teams of enzymes detect and repair the DNA, the nuclease cuts out the damaged DNA and removes it, fills in the missing nucleotides and the DNA ligase seals the free end of the new DNA to the old DNA making the strand complete33
5637182796TelomeresSpecial nucleotide sequences at the ends of chromosomes TTAGGG is repeated between 100-1000 times Prevent the staggered ends of daughter molecule from activitating cell's system for monitoring DNA damage34
5637182797TelomeraseEnzyme that catalyzes the lengthening of telomeres in eukaryotic germ cells and restores the original length and compensating for the shortening that occurs during DNA replication35
5637182798HistonesProteins that are responsible for the first level of DNA packing in chromatin36
5637182799Nucleosomethe basic unit of DNA packing37
5637182803Chromatincomplex of DNA and protein38
5637182804Heterochromatincentromeres and telomeres exist in a highly condensed state with visible irregular clumps making it largely inaccessible39
5637182805Euchromatincentromeres and telomeres exist in a less compacted state that is very accessible40

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