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AP Biology: Genetics Flashcards

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8304001378Beads on a stringNucleosome0
8304001379Protein that DNA wraps aroundHistone1
8304006397String of nucleosomesChromatin2
8304028881Active chromatinEuchromatin3
8304028882Silent, dense chromatinHeterochromatin4
8304034128HaploidOne copy of each chromosome per cell.5
8304034129DiploidTwo full copies of each chromosome6
8304035664PolyploidMore than two full copies of each chromosome7
8304043891Homologous pairsChromosomes with the same genes in the same location, but perhaps different alleles8
8304050900What connects sister chromatids?Centromere9
8304058834KinetochoreCytoskeleton fibers that attach to the centromere to ensure proper separation during mitosis10
8304061782Structural genesSpecific coded instructions for proteins11
8304066088Embryonic genesGenes that affect the development of an embryo but turn off after birth12
8304072592Control regions"Switches" to turn genes on or off13
8304076614TelomereNon-coding areas at the end of each gene that shorten with each replication14
8304102303Parts of the interphaseG1, *G0, S, G215
8304106891What takes up the most of a cell's lifespan?Interphase, 95%16
8304113481G1The cell performs its cellular function and increases in size. DNA exists as single chromosomes. Cells wait for environmental cues to divide.17
8304119686G(0)G1 but cell is not waiting for cues to divide.18
8304122220SDNA is replicated, resulting in chromosomes that consist of two sister chromatids made of dense heterochromatin.19
8304142626G2Cell grows and produces membranes, proteins, and organelles in preparation for division20
8304152068Mitosis (M)The cell is focused on properly lining up the chromosomes and dividing in two. It does not perform its cellular function at this time, and the process lasts only a few hours.21
83041635712 Properties of normal cellsContact inhibition, anchorage dependence22
83041742782 Properties of cancerous cellsGrow and divide rapidly even when crowded, get loose and travel through the blood (metastasis)23
8304181855Cells should only divide in order to...Grow from embryo, grow from young to adult, repair damaged cells, and produce protective structures (skin/hair/bark)24
8304190742G1 CheckpointThe cell receives the signal to divide or not. This is the most vital checkpoint.25
8304206888G2 CheckpointThe cell checks if it has enough nutrients & building materials as well as if each chromosome has a complete sister chromatid.26
8304235175M CheckpointThe cell determines whether its chromosomes are properly lined up across the center. If not, apoptosis occurs. (metaphase of M)27
8304250241CyclinsChemicals made by the cell when growth stimuli exist and degrade after use. These accumulate during G1 and G2. Quick rise --> cell division.28
8304261274Things that cause an increase in cyclinsNeighboring cell dies, high growth hormone concentration, high nutrient concentration, old age of cell, long telomeres, cell type (skin? hair? etc)29
8304272833Things that inhibit cyclin productionCrowding of cells, low growth hormone, low nutrients, young cell age, short telomeres, cell type (neuron?)30
8304280436KinasesProteins that give the go-ahead at cell cycle checkpoints. Work by phosphorylating proteins in the cell, allowing it to perform tasks related to growth and division.31
8304284427Cyclin Dependent KinasesKinases that must bind to a certain cyclin in order to be active.32
8304303077MPFMaturation promoting factor, the G2 cdk that allows mitosis to start.33
8304310637Cyclin Expression Cycle34
8304313873Tumor Suppression genes, and the best known oneGenes that force the cell to commit apoptosis if checkpoints are failed. Best known: p53, which activates DNA repair genes and inactivates certain cdks, thereby halting the cell cycle35
8304330684Proto-oncogenes, and the best known oneGovern go-ahead signals, including the cell's response to cdk and cyclin levels. Best known: ras, mutant versions cause synthesis of a protein inducing kinase synthesis without cyclin.36
8304368320Prophase37
8304370674Metaphase38
8304375496Anaphase39
8304385493Telophase40
8304388937Cytokinesisanimals: cleavage furrow, plants: cell plate41
8304420575Three factors that lead to genetic diversity in sexual reproductionIndependent assortment, crossing over, and mutations42
8304426598Reduction DivisionMeiosis reduces cells from 1 diploid cell to 4 genetically unique haploid gamete cells.43
8304438055What is separated during Meiosis I?Homologous Chromosomes44
8304442242What is separated during Meiosis II?Sister Chromatids45
8304448666When does crossing over occur?During Prophase I46
8304489037Crossover PointChiasmata47
8304501482When are genes not linked?When they are on different chromosomes so they assort independently or when they are far apart so crossing over can occur.48
8304504661When are genes linked?When they are close together so there is little space for a crossing over point between them.49
8304527111Law of Segregation and mutation exceptionAfter meiosis I, allele pairs separate because homologous chromosomes split. Exception: nondisjunction50
8304534388Law of Independent AssortmentTraits (that are not close together on the same chromosome) assort independently of each other.51
83045484999:3:3:1 RatioThe expected appearance of phenotypes in a dihybrid cross: 9 dominant dominant, 3 dominant recessive, 3 recessive dominant, 1 recessive recessive52
8304604924Law of Dominance and exceptions2 Alleles exist for each trait. If at least one dominant allele is present, the organism will express it. Exceptions: incomplete dominance, codominance, pleitropic genes53
8304618010NondisjunctionWhen chromosomes fail to separate properly.54
8304623662Example of Incomplete DominanceRed flower (RR) x White flower (rr) = pink flower (Rr)55
8304625462Example of CodominanceRed cow C^rC^r x White cow C^wC^w = Roan cow C^rC^w56
8304636735Pleitropic GenesGenes that have different effects in different cells. Example: cystic fibrosis, a disease that creates a faulty CFTR chloride ion channel, which harms the function of many organ system57
8304658583Environmental factors that affect gene expressionAltitude, temperature, activity level, and nutrition can all change how an organism expresses its genes. For example, hydrangea flowers are different colors depending on the pH of the soil.58
8304676405Quantitative CharacteristicsTraits that show variance along a continuum, usually because there are multiple genes involved.59
8304679678Polygenic traitsTraits which are determined by multiple genes.60
8304702004EpistasisWhen one gene regulates the expression of another, so that if it is turned off, the phenotype will be a certain way regardless of the other genotype61
8304827967Sex Linked TraitFound on the X Chromosome. Recessive: men inherit them from their mothers and express it more often than females because they only have one copy of the gene62
8304852019Barr bodyX Chromosome turned off and massed. Random one for each nucleus63

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