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9911727099Dehydrationconnecting monomers together by the removal of water0
9911727100Hydrolysisdisassembling polymers by the addition of water1
9911727101Disaccharidesglucose + glucose = maltose / glucose + fructose = sucrose / glucose + galactose = lactose2
9911727102PolysaccharidesPlants: starch (energy) and cellulose (structure) Animals: glycogen (energy) and chitin (structure)3
9911727103*Lipidshydrophobic (very non-polar), consist of long hydrocarbon chains4
9911727104Fatsconsist of glycerol and 3 fatty acids, store long term energy, saturated = no double bond in hydrocarbon tails (no kink), unsaturated = double bond (kink)5
9911727105Phospholipidsconsist of phosphate head, glycerol, and 2 fatty acid tails, tail is hydrophobic, head is hydrophillic6
9911727106Protein structure and organizationcomposed of an amino group, a carboxyl group, hydrogen, and an R group, joined by peptide bonds and folded numerous times; 1) Primary (linear sequence) 2) Secondary (helix or pleat) 3) Tertiary 4) Quaternary (globular)7
9911727107Protein functions (8)1) enzymes 2) antibodies 3) storage proteins 4) transport proteins 5) hormones 6) receptor proteins 7) motor proteins 8) structural proteins8
9911727108*Nucleic AcidsDNA (A+T, G+C) carries genetic info, RNA (A+U, G+C) manufactures proteins9
9911727109Nuclear Envelopedouble membrane enclosing the nucleus (where genetic info is stored) perforated with pores, continuous with ER10
9911727110Chromatinuncondensed DNA that forms chromosomes during cell division11
9911727111Nucleolusnonmembranous structure involved in production of ribosomes, a nucleus has one or more of these12
9911727112Rough ERcovered in ribosomes, secretes and transports proteins produced by ribosomes13
9911727113Smooth ERmetabollic processes (synthesis of lipids, metabolism of carbs, detoxification of drugs and poisons)14
9911727114Golgistores, transports, and secretes cell products15
9911727115Cytoskeletonsupports cell, maintains its shape, aids in movement of cell products16
9911727116Centrosomes (2 centrioles)only in animal cells, microtubules used for cell division17
9911727117Lysosomesonly in animal cells, digestive organelles18
9911727118Flagellaonly in animal cells, cluster of microtubules for motility19
9911727119Extracellular Matrixonly in animal cells, made of proteins that provide support for cells and relay information for communication between the environment and the cell20
9911727120Central Vacuoleonly in plant cells, stores water and sugar, breaks down waste, and used as a mechanism for plant growth (when it swells)21
9911727121Prokaryotic vs. Eukaryoticnucleoid / nucleus; only ribosomes / complex membrane-bound organelles; both have same genetic coding, sugars, and amino acids22
9911727122Phospholipid Bilayertails of phospholipids are loosely packed and are in constant motion; membrane contains integral and peripheral proteins, cholestrol, and glycopreotins and glycolipids; cholesterol makes the membrane less permeable to water and other substances; non-polar and small polar molecules can pass through unadied23
9911727123Passive trasportmovement of molecules without requirement of energy: 1) diffusion 2) osmosis (across a membrane) 3) facilitated diffusion (helped by transport proteins)24
9911727124Active transportmovement of molecules that requires energy: 1) sodium-potassium pumps 2) exocytosis 3) endocytosis (phagocytosis, pinocytosis)25
9911727125Membrane Potentialvoltage across a membrane due to difference in positive and negative ions, electrons move from high to low concentration (ex. sodium-potassium pumps in neurons)26
9911727126Electrochemical Gradientdiffusion gradient resulting in combination of membrane potential and concentration gradient27
9911727127Hypertonicsolution with higher concentration of solutes, animal/plant cell in this solution would become shiveled/plasmolyzed28
9911727128Hypotonicsolution with lower concentration of solutes, animal/plant cell in this solution would lyse/become turgid29
9911727129Isotonicequal levels of solute concentration, plant cell in this solution would become flaccid30
9911727130When ΔG is negative......the reaction is exergonic (loss of free energy).31
9911727131When ΔG is positive......the reaction is endergonic (gain of free energy).32
9911727132*Enzymesproteins that are biological catalysts, lower the activation energy required to start a chemical reaction (reactants at unstable transition state) can be used over and over33
9911727133Substratethe substance that an enzyme acts upon34
9911727134Active Siteregion of enzyme that binds to the substrate35
9911727135Induced fitchange in the shape of an enzyme's active site induced by the substrate, helps to break down the substrate36
9911727136The higher the substrate concentration......the faster the reaction until the enzyme becomes saturated.37
9911727137Denaturationthe unraveling of an enzyme due to high temperatures or incompatible pH38
9911727138Cofactorsnonprotein molecules that are required for proper enzyme function, cofactors made of organic molecules are called coenzymes39
9911727139Enzyme inhibition may be irreversible if......the inhibitor attaches by covalent bonds (poisons, toxins)40
9911727140Competitive Inhibitorsresemble a substrate and block enzymes' active sites, can be overcome with higher concentration of substrate41
9911727141Noncompetitive Inhibitorsbind to a portion of the enzyme and change the shape of the active site so that it cannot match with substrates, used for regulating metabolic reactions42
9911727142Feedback Inhibitionthe product of a metabolic pathway switches off the enzyme that created it earlier in the process43
9911727143Oxidationloss of electrons (OIL)44
9911727144Reductiongain of electrons (RIG)45
9911727145Oxidative PhosphorylationATP synthesis powered by redox reactions that transfer electrons to oxygen46
9911727146Electron AcceptorsCellular respiration: NAD+ and FAD (to NADH and FADH2) Photosynthesis: NADP+ (to NADPH)47
9911727147GlycolysisInput: glucose, 2 ATP Output: 2 pyruvic acid, 4 ATP (net 2), 2 NADH48
9911727148Conversion Reaction before Kreb'sInput: 2 pyruvate Output: 2 acetyl (w/ CoA), 2 NADH, 2 CO249
9911727149Krebs CycleInput: 2 acetyl ➝ citric acid Output: 2 ATP, 6 NADH, 2 FADH2, 4 CO2 (after 2 turns of the cycle)50
9911727150Electron Transport ChainInput: NADH, FADH2, O2 (to accept e-) Output: 34-38 ATP, H2O51
9911727151Alcohol FermentationInput: glucose, 2 ATP, 2 NADH Output: 2 NAD+, 2 ethanol, 2 CO2, 4 ATP (net 2)52
9911727152Lactic Acid FermentationInput: glucose, 2 ATP, 2 NADH Output: 2 NAD+, 2 lactate, 4 ATP (net 2)53
9911727244Photosynthetic Equation54
9911727153Chloroplast structureExciting chlorophyll: chlorophyll in thylakoids absorb light, which excites electrons to produce potential energy55
9911727154Light ReactionsInput: H2O (2 e-), light energy, NADP+ Output: O2, ATP, NADPH56
9911727155Calvin CycleInput: 6 CO2 (fixed to RuBP by Rubisco), ATP, NADPH Output: 2 G3P = 1 glucose57
9911727156Watson and Crickbuilt the first accurate 3D DNA model58
9911727157Leading Strand vs. Lagging Strandworks toward replication fork / works away from replication fork; both always move in the 5' ➝ 3' direction59
9911727158Steps of DNA Replication1) helicase separates the DNA strands 2) SSB proteins prevent DNA from reanneling 3) primase creates RNA primer 4) DNA polymerase extends DNA strand from the primer 5) DNA polymerase I (RNase H) removes the primers 6) ligase joins the okazaki fragments of the lagging strand60
99117271593 types of RNA1) mRNA messenger 2) tRNA transfer amino acids (20 kinds) 3) rRNA ribosomes61
9911727160Transcription1) Initiation: promoter site (TATA) is recognized 2) Elongation: RNA polymerase adds ribonucleotides in the 5' ➝ 3' direction 3) Termination: RNA strand separates, RNA polymerase recognizes termination sequence (AAUAAA)62
9911727161RNA processing/splicingsplicesomes remove introns and put together exons, 5' cap and PolyA tail are added63
9911727162Codon vs. Anticodoncodon = nucleotide sequence on mRNA anticodon = nucleotide sequence on tRNA64
9911727163Translation1) Initiation: 5' cap attaches to ribosome which accepts an initiator tRNA at the P site (*AUG will always be 1st codon) 2) Elongation: codon/anticodon recognition and formation of peptide bond between A site amino acid and P site amino acid chain 3) translocation of the ribosome down the mRNA strand 4) Termination: ribosome will recognize stop codon and release the protein65
9911727164DNA mutationsbase-pair substitution; insertion/deletion; frameshift: 1) missense = different protein 2) nonsense = codes for a stop signal prematurely 3) silent = no harmful change66
9911727165Prokaryotic cell divisionbinary fission: splits in 2, exact copies, quick and efficient with few mutations, but reduces amount of genetic variation67
9911727166Somatic cell vs. Gameteany body cell except gametes / reproductive cells (sperm, egg)68
9911727167Interphase(90% of cell's life) G1: 1st growth, normal metabolic activity (goes into G0 phase if it is not ready for next phase); S: synthesis, DNA replication; G2: 2nd growth, prepares for mitosis69
9911727168Mitosis1) Prophase: chromatin condenses into chromosomes, nucleus disappears 2) Metaphase: chromosomes line up at equator, kinetechore microtubules attach 3) Anaphase: sister chromatids move to opposite poles of the cell 4) Telophase and Cytokinesis: daughter cells separate, nucleus reforms, chromosomes decondense70
9911727169Cyclin-dependent Kinases (Cdks)a regulatory protein that depends upon the presence of cyclin to complete its function, MPF is a Cdk that triggers a cell's passage into the M phase71
9911727170Meiosis I1) Prophase I: homologous chromosomes pair up and synapsis occurs, crossing over segments of the chromosomes (chiasma) to create more genetic variation 2) Metaphase I: homologous chromosomes line up at the equator 3) Anaphase: homologous chromosomes move to opposite poles of the cell. 4) Telophase I...72
9911727171Meiosis IIProphase II - Telophase II act exactly like mitosis except that the resultant number of daughter cells is 4 instead of 2, each with their own unique combination of genetic information73
99117271724 mechanisms that contribute to genetic variation1) Mutation 2) Independent Assortment: homologous chromosomes align randomly on one side of the equator or another 3) Crossing Over 4) Random Fertilization: a zygote can be any combination of a sperm and egg (64 trillion different combinations in humans)74
9911727173Testcrossbreed a homozygous recessive individual with an individual with a dominant phenotype but an unknown genotype to determine whether or not the individual is homozygous or heterozygous75
9911727174Dyhybrid heterozygous cross ratio9:3:3:176
9911727175Incomplete Dominanceheterozygous offspring have an intermediate phenotype of the parents, 1:2:1 ratio (ex. pink flower from red and white flowers)77
9911727176Codominanceboth alleles manifest themselves separately in an organism's phenotype (ex. roan cattle)78
9911727177Multiple allelesa trait controlled by two or more alleles (ex. blood type, eye color)79
9911727178Blood TypesA: A antigen, B antibody B: B antigen, A antibody AB: A and B antigen, no antibodies (universal recipient) O: no antigens, A and B antibodies (universal donor)80
9911727179Polygenic Inheritancethe additive effect of 2 or more independently assorted genes on phenotype (ex. human skin pigment)81
9911727180Linked genes phenotypic ratiotwo large numbers (wild and mutant) and two much smaller numbers (recombinant phenotypes)82
9911727181Genetic Map (Linkage/Cytological Map)ordered list of the genetic loci along a particular chromosome, recombinant frequencies can be used to construct it (smaller the percentage = closer together)83
9911727182X Inactivationin females during embryonic development, one of the two X chromosomes in a cell becomes inactive (Barr body) (ex. calico cats)84
9911727183Nondisjucntionhomologous chromosomes fail to separate during meiosis I or II85
9911727184Aneuploidyone or more chromosomes are present in extra copies or are deficient in number; Trisomic = 3 copies instead of 2, Monosomic = 1 copy instead of 286
9911727185Polyploidywhen there is a whole extra set of chromosomes (ex. oversized fruits); Triploidy = 3 sets, Tetraploidy = 4 sets87
99117271864 alterations to gene structure1) Deletion: removal of chromosomal segment 2) Duplication: repetition of a segment 3) Inversion: reversal of a segment within a chromosome 4) Translocation: movement of a segment from one chromosome to another, non-homologous one88
99117271873 stages in cell cummunication1) Reception: cell detects a signal via connection of a ligand to a receptor protein 2) Transduction: the receptor protein converts the signal to a form that can cause a chemical response 3) Response: transduced signal triggers a specific cellular response89
9911727188Types of cell signaling (4)synaptic, paracrine, hormonal90
9911727189Examples of cell signalingG-protein coupled receptor, ligand-gated ion channels, steroid hormones (dissolved across plasma membrane, intracellular receptor)91
9911727190Second Messengers and Phosphorylation cascadesecond messengers and kinases spread throughout a cell that help amplify a cellular signal by a series of phosphorylation reactions (addition of phosphate)92
9911727191Virus structurenonliving, can't rproduce on their own; Capsid: protein coat that encloses the viral genome; Envelope: membrane that surrounds some viral capsids; Phage: protein encapsulated virus that attacks bacteria93
9911727192Lytic Cycle1) virus attaches to host cell 2) phage DNA enters cell and the cell's DNA degrades (*restriction enzymes in bacteria could destroy them) 3) synthesis of viral genomes and proteins 4) assembly of phages within cell 5) release of viruses, destroys cell94
9911727193Lysogenic Cyclethe virus inserts its DNA into a host cell, and its DNA integrates with the DNA of the host, allows it to be replicated without being attacked for long periods of time before entering the lytic cycle95
9911727194RetrovirusRNA virus that transcribes its RNA into DNA to insert into host cells (ex. HIV)96
9911727195Provirusa viral genome that is permanently inserted into a host genome97
9911727196Viral Transductioncontributes to bacterial genetic variation98
9911727197Repressible Operontrp operon - usually on, can be repressed. Repressor protein produced in inactive shape99
9911727198Inducible Operonlac operon - usually off, can be turned on. Repressor protein produced in active shape.100
9911727199cAMP and CAP regulated Operonwhen CAP is inactive, transcription continues at a much less efficient rate even in the presence of lactose101
9911727200Histone Acetylationthe loosening of chromatin structure (euchromatin), promotes transcription102
9911727201Histone Methylationthe condensing of chromatin structure (heterochromatin), prevents transcription103
9911727202Transcription Factors and EnhancersRNA polymerase requires the assistance of transcription factor proteins and enhancers or activators to successfully transcribe RNA104
9911727203Epigenetic Inheritanceinheritance of traits not directly related to nucleotide sequence (ex. fat, sickly, yellow rats were fed a methylated diet, resulted in offspring that were normal-sized, healthy, and brown)105
99117272045 Evidences for Evolution1) Biogeography 2) Fossil Record 3) Comparative Anatomy 4) Comparative Embryology 5) Molecular Biology106
99117272054 conditions for Hardy-Weinberg Equilibrium (not evolving)1) very large population 2) isolation from other populations 3) no mutations 4) no natural selection107
9911727206Microevolution vs. Macroevolutionchange in the gene pool of a population over several generations / large scale changes in a population that leads to the evolution of a new species108
99117272074 causes of Microevolution1) genetic drift 2) gene flow 4) natural selection109
9911727208Genetic Driftrandom change in gene frequency of a small breeding population: 1) Founder Effect = small population of organisms colonizes a new area, 2) Bottleneck Effect = sudden decrease in population size due to disaster110
9911727209Gene Flowloss/addition of alleles from a population due to imigration/emigration111
9911727210Nonrandom Matingselection of mates for specific phenotypes: 1) Assortative Mating = when individuals select partners with simple phenotypic characters, 2) Inbreeding = more recessive traits likely to come together112
99117272113 Modes of Natural Selection1) Stabilizing: favors intermediate, 2) Directional: favors one extreme phenotype, 3) Diversifying: favors both extremes113
9911727212Heterozygote Advantageheterozygotes for a trait are more likely to survive (ex. carriers of sickle cell anemia are immune to malaria)114
9911727213Biological Species Conceptpopulation whose members can create viable, fertile offspring (Problems: doesn't apply to extinct animals or asexually reproducing organisms)115
9911727214Prezygotic Reproductive Barriers1) Habitat Isolation 2) Behavioral Isolation (differing behaviors for attracting mates) 3) Temporal Isolation (mate at different times) 4) Mechanical Isolation 5) Gametic Isolation (unable to fertilize egg)116
9911727215Postzygotic Reproductive Barriers1) Reduced Hybrid Viability (disruption in embryonic stage) 2) Reduced Hybrid Fertility 3) Hybrid Breakdown (F1 is fertile, F2 is sterile or weak)117
9911727216Allopatric Speciationwhen populations become geographically isolated from the rest of the species and has the potential to develop a new species (ex. Adaptive Radiation: many diversely adapted species from common ancestor, Darwin's finches)118
9911727217Sympatric Speciationmembers of a population develop gametic differences that prevent them from reproducing with the parental type (polyploidy, not as common)119
9911727218Punctuated Equilibrium vs. Gradualismevolution occurs in short spurts of rapid change / each new species will evolve gradually over long spans of time120
9911727219Convergent Evolutiondifferent organisms that occupy similar environments come to resemble one another (ex. dolphins and sharks)121
9911727220EndosymbiosisOrigin of mitochondria and chloroplasts. Evidence: They have their own DNA and ribosomes, double membrane structure, grow and reproduce on their own within the cell122
9911727221Phylogenyevolutionary history of a species or group of related species123
9911727222Taxonomic groups from broad to narrow (8)Domain, Kingdom, Phylum, Class, Order, Family, Genus, Species124
99117272233 mechanisms in which bacteria transfer genetic materials1) Transformation: prokaryote takes up DNA from its environment 2) Transduction: viruses transfer genes between prokaryotes 3) Conjugation: genes are directly transferred from one prokaryote to another over a temporary "mating bridge"125
9911727224Types of Symbiotic RelationshipsMutualism (+, +), Commensalism (+, 0), Parasitism, (+, -)126
9911727225Factors that influence Transpiration RateTemperature: higher temperature, faster rate; Humidity: higher humidity, slower rate; Sunlight: more sun, faster rate; Wind: more wind, faster rate127
9911727226Lines of Immune Defense1st Line) skin oil and sweat, mucous; 2nd Line) nonspecific phagocytes and cytotoxic immune cells; 3rd Line) specific immune system128
9911727245Primary and Secondary Immune Response129
9911727227Active vs. Passive Immunitydepends on the response of a person's own immune system (artificial = vaccines) / immunity passed from one organism to another130
9911727228B cells vs. T cells (maturation)mature in bone marrow / mature in thymus131
9911727246Humoral vs. Cell-Mediated Immune Responses132
9911727229Non-steroid hormone vs. Steroid hormonetravels in bloodstream, binds to receptor on cell surface / travels in bloodstream, binds to receptor inside the cell133
9911727230Endotherms vs. Ectothermswarmed by heat generated by metabolism (mammals, birds) / generate little metabolic heat, warmed by environment134
9911727231Nichea position/role taken by a kind of organism within its community135
9911727232Resource Partitioningdivision of environmental resources by coexisting species136
9911727233Per capita Growth Ratebirth - death / total population137
9911727234Exponential vs. Logistic Growthin logistic growth, carrying capacity will limit the population's size138
9911727235Density-dependent RegulationDensity-independent: natural disasters, human impact, etc.139
9911727236Keystone Speciesspecies that exerts strong control on community structure not by numerical might but by their pivotal ecological roles or niches140
9911727237Energy Pyramideach energy level receives only 10% of the pervious level's energy141
9911727238Gross Primary Production vs. Net Primary Productiontotal amount of energy from light converted to chemical energy to organic molecules / GPP - energy used by primary producers for "autotrophic respiration"142
9911727239Carbon CycleConnect photosynthesis (fixation) to cellular respiration (CO2 release)143
9911727240Plasmidsa small, circular, double-stranded DNA molecule that carries accessory genes separate from those of a bacterial chromosome144
9911727241Recombinant DNAa DNA vector made in vitro with segments from different sources145
9911727242Restriction Enzymean enzyme that recognizes and cuts DNA molecules at specific nucleotide sequences (restriction sites), can then be used to create recombinant DNA146
9911727243Gel Electrophoresisanalyzing fragments of DNA (RFLPs) by their length and charge to determine genetic fingerprints and other genetic information147

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