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6654810361Dehydrationconnecting monomers together by the removal of water0
6654810362Hydrolysisdisassembling polymers by the addition of water1
6654810363Disaccharidesglucose + glucose = maltose / glucose + fructose = sucrose / glucose + galactose = lactose2
6654810364PolysaccharidesPlants: starch (energy) and cellulose (structure) Animals: glycogen (energy) and chitin (structure)3
6654810365*Lipidshydrophobic (very non-polar), consist of long hydrocarbon chains4
6654810366Fatsconsist of glycerol and 3 fatty acids, store long term energy, saturated = no double bond in hydrocarbon tails (no kink), unsaturated = double bond (kink)5
6654810367Phospholipidsconsist of phosphate head, glycerol, and 2 fatty acid tails, tail is hydrophobic, head is hydrophillic6
6654810368Protein structure and organizationcomposed of an amino group, a carboxyl group, hydrogen, and an R group, joined by peptide bonds and folded numerous times; 1) Primary (linear sequence) 2) Secondary (helix or pleat) 3) Tertiary 4) Quaternary (globular)7
6654810369Protein functions (8)1) enzymes 2) antibodies 3) storage proteins 4) transport proteins 5) hormones 6) receptor proteins 7) motor proteins 8) structural proteins8
6654810370*Nucleic AcidsDNA (A+T, G+C) carries genetic info, RNA (A+U, G+C) manufactures proteins9
6654810371Nuclear Envelopedouble membrane enclosing the nucleus (where genetic info is stored) perforated with pores, continuous with ER10
6654810372Chromatinuncondensed DNA that forms chromosomes during cell division11
6654810373Nucleolusnonmembranous structure involved in production of ribosomes, a nucleus has one or more of these12
6654810374Rough ERcovered in ribosomes, secretes and transports proteins produced by ribosomes13
6654810375Smooth ERmetabollic processes (synthesis of lipids, metabolism of carbs, detoxification of drugs and poisons)14
6654810376Golgistores, transports, and secretes cell products15
6654810377Cytoskeletonsupports cell, maintains its shape, aids in movement of cell products16
6654810378Centrosomes (2 centrioles)only in animal cells, microtubules used for cell division17
6654810379Lysosomesonly in animal cells, digestive organelles18
6654810380Flagellaonly in animal cells, cluster of microtubules for motility19
6654810381Extracellular Matrixonly in animal cells, made of proteins that provide support for cells and relay information for communication between the environment and the cell20
6654810382Central Vacuoleonly in plant cells, stores water and sugar, breaks down waste, and used as a mechanism for plant growth (when it swells)21
6654810383Prokaryotic vs. Eukaryoticnucleoid / nucleus; only ribosomes / complex membrane-bound organelles; both have same genetic coding, sugars, and amino acids22
6654810384Phospholipid Bilayertails of phospholipids are loosely packed and are in constant motion; membrane contains integral and peripheral proteins, cholestrol, and glycopreotins and glycolipids; cholesterol makes the membrane less permeable to water and other substances; non-polar and small polar molecules can pass through unadied23
6654810385Passive trasportmovement of molecules without requirement of energy: 1) diffusion 2) osmosis (across a membrane) 3) facilitated diffusion (helped by transport proteins)24
6654810386Active transportmovement of molecules that requires energy: 1) sodium-potassium pumps 2) exocytosis 3) endocytosis (phagocytosis, pinocytosis)25
6654810387Membrane Potentialvoltage across a membrane due to difference in positive and negative ions, electrons move from high to low concentration (ex. sodium-potassium pumps in neurons)26
6654810388Electrochemical Gradientdiffusion gradient resulting in combination of membrane potential and concentration gradient27
6654810389Hypertonicsolution with higher concentration of solutes, animal/plant cell in this solution would become shiveled/plasmolyzed28
6654810390Hypotonicsolution with lower concentration of solutes, animal/plant cell in this solution would lyse/become turgid29
6654810391Isotonicequal levels of solute concentration, plant cell in this solution would become flaccid30
6654810392When ΔG is negative......the reaction is exergonic (loss of free energy).31
6654810393When ΔG is positive......the reaction is endergonic (gain of free energy).32
6654810394*Enzymesproteins that are biological catalysts, lower the activation energy required to start a chemical reaction (reactants at unstable transition state) can be used over and over33
6654810395Substratethe substance that an enzyme acts upon34
6654810396Active Siteregion of enzyme that binds to the substrate35
6654810397Induced fitchange in the shape of an enzyme's active site induced by the substrate, helps to break down the substrate36
6654810398The higher the substrate concentration......the faster the reaction until the enzyme becomes saturated.37
6654810399Denaturationthe unraveling of an enzyme due to high temperatures or incompatible pH38
6654810400Cofactorsnonprotein molecules that are required for proper enzyme function, cofactors made of organic molecules are called coenzymes39
6654810401Enzyme inhibition may be irreversible if......the inhibitor attaches by covalent bonds (poisons, toxins)40
6654810402Competitive Inhibitorsresemble a substrate and block enzymes' active sites, can be overcome with higher concentration of substrate41
6654810403Noncompetitive Inhibitorsbind to a portion of the enzyme and change the shape of the active site so that it cannot match with substrates, used for regulating metabolic reactions42
6654810404Feedback Inhibitionthe product of a metabolic pathway switches off the enzyme that created it earlier in the process43
6654810405Oxidationloss of electrons (OIL)44
6654810406Reductiongain of electrons (RIG)45
6654810407Oxidative PhosphorylationATP synthesis powered by redox reactions that transfer electrons to oxygen46
6654810408Electron AcceptorsCellular respiration: NAD+ and FAD (to NADH and FADH2) Photosynthesis: NADP+ (to NADPH)47
6654810409GlycolysisInput: glucose, 2 ATP Output: 2 pyruvic acid, 4 ATP (net 2), 2 NADH48
6654810410Conversion Reaction before Kreb'sInput: 2 pyruvate Output: 2 acetyl (w/ CoA), 2 NADH, 2 CO249
6654810411Krebs CycleInput: 2 acetyl ➝ citric acid Output: 2 ATP, 6 NADH, 2 FADH2, 4 CO2 (after 2 turns of the cycle)50
6654810412Electron Transport ChainInput: NADH, FADH2, O2 (to accept e-) Output: 34-38 ATP, H2O51
6654810413Alcohol FermentationInput: glucose, 2 ATP, 2 NADH Output: 2 NAD+, 2 ethanol, 2 CO2, 4 ATP (net 2)52
6654810414Lactic Acid FermentationInput: glucose, 2 ATP, 2 NADH Output: 2 NAD+, 2 lactate, 4 ATP (net 2)53
6654810415Photosynthetic Equation54
6654810416Chloroplast structureExciting chlorophyll: chlorophyll in thylakoids absorb light, which excites electrons to produce potential energy55
6654810417Light ReactionsInput: H2O (2 e-), light energy, NADP+ Output: O2, ATP, NADPH56
6654810418Calvin CycleInput: 6 CO2 (fixed to RuBP by Rubisco), ATP, NADPH Output: 2 G3P = 1 glucose57
6654810419Watson and Crickbuilt the first accurate 3D DNA model58
6654810420Leading Strand vs. Lagging Strandworks toward replication fork / works away from replication fork; both always move in the 5' ➝ 3' direction59
6654810421Steps of DNA Replication1) helicase separates the DNA strands 2) SSB proteins prevent DNA from reanneling 3) primase creates RNA primer 4) DNA polymerase extends DNA strand from the primer 5) DNA polymerase I (RNase H) removes the primers 6) ligase joins the okazaki fragments of the lagging strand60
66548104223 types of RNA1) mRNA messenger 2) tRNA transfer amino acids (20 kinds) 3) rRNA ribosomes61
6654810423Transcription1) Initiation: promoter site (TATA) is recognized 2) Elongation: RNA polymerase adds ribonucleotides in the 5' ➝ 3' direction 3) Termination: RNA strand separates, RNA polymerase recognizes termination sequence (AAUAAA)62
6654810424RNA processing/splicingsplicesomes remove introns and put together exons, 5' cap and PolyA tail are added63
6654810425Codon vs. Anticodoncodon = nucleotide sequence on mRNA anticodon = nucleotide sequence on tRNA64
6654810426Translation1) Initiation: 5' cap attaches to ribosome which accepts an initiator tRNA at the P site (*AUG will always be 1st codon) 2) Elongation: codon/anticodon recognition and formation of peptide bond between A site amino acid and P site amino acid chain 3) translocation of the ribosome down the mRNA strand 4) Termination: ribosome will recognize stop codon and release the protein65
6654810427DNA mutationsbase-pair substitution; insertion/deletion; frameshift: 1) missense = different protein 2) nonsense = codes for a stop signal prematurely 3) silent = no harmful change66
6654810428Prokaryotic cell divisionbinary fission: splits in 2, exact copies, quick and efficient with few mutations, but reduces amount of genetic variation67
6654810429Somatic cell vs. Gameteany body cell except gametes / reproductive cells (sperm, egg)68
6654810430Interphase(90% of cell's life) G1: 1st growth, normal metabolic activity (goes into G0 phase if it is not ready for next phase); S: synthesis, DNA replication; G2: 2nd growth, prepares for mitosis69
6654810431Mitosis1) Prophase: chromatin condenses into chromosomes, nucleus disappears 2) Metaphase: chromosomes line up at equator, kinetechore microtubules attach 3) Anaphase: sister chromatids move to opposite poles of the cell 4) Telophase and Cytokinesis: daughter cells separate, nucleus reforms, chromosomes decondense70
6654810432Cyclin-dependent Kinases (Cdks)a regulatory protein that depends upon the presence of cyclin to complete its function, MPF is a Cdk that triggers a cell's passage into the M phase71
6654810433Meiosis I1) Prophase I: homologous chromosomes pair up and synapsis occurs, crossing over segments of the chromosomes (chiasma) to create more genetic variation 2) Metaphase I: homologous chromosomes line up at the equator 3) Anaphase: homologous chromosomes move to opposite poles of the cell. 4) Telophase I...72
6654810434Meiosis IIProphase II - Telophase II act exactly like mitosis except that the resultant number of daughter cells is 4 instead of 2, each with their own unique combination of genetic information73
66548104354 mechanisms that contribute to genetic variation1) Mutation 2) Independent Assortment: homologous chromosomes align randomly on one side of the equator or another 3) Crossing Over 4) Random Fertilization: a zygote can be any combination of a sperm and egg (64 trillion different combinations in humans)74
6654810436Testcrossbreed a homozygous recessive individual with an individual with a dominant phenotype but an unknown genotype to determine whether or not the individual is homozygous or heterozygous75
6654810437Dyhybrid heterozygous cross ratio9:3:3:176
6654810438Incomplete Dominanceheterozygous offspring have an intermediate phenotype of the parents, 1:2:1 ratio (ex. pink flower from red and white flowers)77
6654810439Codominanceboth alleles manifest themselves separately in an organism's phenotype (ex. roan cattle)78
6654810440Multiple allelesa trait controlled by two or more alleles (ex. blood type, eye color)79
6654810441Blood TypesA: A antigen, B antibody B: B antigen, A antibody AB: A and B antigen, no antibodies (universal recipient) O: no antigens, A and B antibodies (universal donor)80
6654810442Polygenic Inheritancethe additive effect of 2 or more independently assorted genes on phenotype (ex. human skin pigment)81
6654810443Linked genes phenotypic ratiotwo large numbers (wild and mutant) and two much smaller numbers (recombinant phenotypes)82
6654810444Genetic Map (Linkage/Cytological Map)ordered list of the genetic loci along a particular chromosome, recombinant frequencies can be used to construct it (smaller the percentage = closer together)83
6654810445X Inactivationin females during embryonic development, one of the two X chromosomes in a cell becomes inactive (Barr body) (ex. calico cats)84
6654810446Nondisjucntionhomologous chromosomes fail to separate during meiosis I or II85
6654810447Aneuploidyone or more chromosomes are present in extra copies or are deficient in number; Trisomic = 3 copies instead of 2, Monosomic = 1 copy instead of 286
6654810448Polyploidywhen there is a whole extra set of chromosomes (ex. oversized fruits); Triploidy = 3 sets, Tetraploidy = 4 sets87
66548104494 alterations to gene structure1) Deletion: removal of chromosomal segment 2) Duplication: repetition of a segment 3) Inversion: reversal of a segment within a chromosome 4) Translocation: movement of a segment from one chromosome to another, non-homologous one88
66548104503 stages in cell cummunication1) Reception: cell detects a signal via connection of a ligand to a receptor protein 2) Transduction: the receptor protein converts the signal to a form that can cause a chemical response 3) Response: transduced signal triggers a specific cellular response89
6654810451Types of cell signaling (4)synaptic, paracrine, hormonal90
6654810452Examples of cell signalingG-protein coupled receptor, ligand-gated ion channels, steroid hormones (dissolved across plasma membrane, intracellular receptor)91
6654810453Second Messengers and Phosphorylation cascadesecond messengers and kinases spread throughout a cell that help amplify a cellular signal by a series of phosphorylation reactions (addition of phosphate)92
6654810454Virus structurenonliving, can't rproduce on their own; Capsid: protein coat that encloses the viral genome; Envelope: membrane that surrounds some viral capsids; Phage: protein encapsulated virus that attacks bacteria93
6654810455Lytic Cycle1) virus attaches to host cell 2) phage DNA enters cell and the cell's DNA degrades (*restriction enzymes in bacteria could destroy them) 3) synthesis of viral genomes and proteins 4) assembly of phages within cell 5) release of viruses, destroys cell94
6654810456Lysogenic Cyclethe virus inserts its DNA into a host cell, and its DNA integrates with the DNA of the host, allows it to be replicated without being attacked for long periods of time before entering the lytic cycle95
6654810457RetrovirusRNA virus that transcribes its RNA into DNA to insert into host cells (ex. HIV)96
6654810458Provirusa viral genome that is permanently inserted into a host genome97
6654810459Viral Transductioncontributes to bacterial genetic variation98
6654810460Repressible Operontrp operon - usually on, can be repressed. Repressor protein produced in inactive shape99
6654810461Inducible Operonlac operon - usually off, can be turned on. Repressor protein produced in active shape.100
6654810462cAMP and CAP regulated Operonwhen CAP is inactive, transcription continues at a much less efficient rate even in the presence of lactose101
6654810463Histone Acetylationthe loosening of chromatin structure (euchromatin), promotes transcription102
6654810464Histone Methylationthe condensing of chromatin structure (heterochromatin), prevents transcription103
6654810465Transcription Factors and EnhancersRNA polymerase requires the assistance of transcription factor proteins and enhancers or activators to successfully transcribe RNA104
6654810466Epigenetic Inheritanceinheritance of traits not directly related to nucleotide sequence (ex. fat, sickly, yellow rats were fed a methylated diet, resulted in offspring that were normal-sized, healthy, and brown)105
66548104675 Evidences for Evolution1) Biogeography 2) Fossil Record 3) Comparative Anatomy 4) Comparative Embryology 5) Molecular Biology106
66548104684 conditions for Hardy-Weinberg Equilibrium (not evolving)1) very large population 2) isolation from other populations 3) no mutations 4) no natural selection107
6654810469Microevolution vs. Macroevolutionchange in the gene pool of a population over several generations / large scale changes in a population that leads to the evolution of a new species108
66548104704 causes of Microevolution1) genetic drift 2) gene flow 4) natural selection109
6654810471Genetic Driftrandom change in gene frequency of a small breeding population: 1) Founder Effect = small population of organisms colonizes a new area, 2) Bottleneck Effect = sudden decrease in population size due to disaster110
6654810472Gene Flowloss/addition of alleles from a population due to imigration/emigration111
6654810473Nonrandom Matingselection of mates for specific phenotypes: 1) Assortative Mating = when individuals select partners with simple phenotypic characters, 2) Inbreeding = more recessive traits likely to come together112
66548104743 Modes of Natural Selection1) Stabilizing: favors intermediate, 2) Directional: favors one extreme phenotype, 3) Diversifying: favors both extremes113
6654810475Heterozygote Advantageheterozygotes for a trait are more likely to survive (ex. carriers of sickle cell anemia are immune to malaria)114
6654810476Biological Species Conceptpopulation whose members can create viable, fertile offspring (Problems: doesn't apply to extinct animals or asexually reproducing organisms)115
6654810477Prezygotic Reproductive Barriers1) Habitat Isolation 2) Behavioral Isolation (differing behaviors for attracting mates) 3) Temporal Isolation (mate at different times) 4) Mechanical Isolation 5) Gametic Isolation (unable to fertilize egg)116
6654810478Postzygotic Reproductive Barriers1) Reduced Hybrid Viability (disruption in embryonic stage) 2) Reduced Hybrid Fertility 3) Hybrid Breakdown (F1 is fertile, F2 is sterile or weak)117
6654810479Allopatric Speciationwhen populations become geographically isolated from the rest of the species and has the potential to develop a new species (ex. Adaptive Radiation: many diversely adapted species from common ancestor, Darwin's finches)118
6654810480Sympatric Speciationmembers of a population develop gametic differences that prevent them from reproducing with the parental type (polyploidy, not as common)119
6654810481Punctuated Equilibrium vs. Gradualismevolution occurs in short spurts of rapid change / each new species will evolve gradually over long spans of time120
6654810482Convergent Evolutiondifferent organisms that occupy similar environments come to resemble one another (ex. dolphins and sharks)121
6654810483EndosymbiosisOrigin of mitochondria and chloroplasts. Evidence: They have their own DNA and ribosomes, double membrane structure, grow and reproduce on their own within the cell122
6654810484Phylogenyevolutionary history of a species or group of related species123
6654810485Taxonomic groups from broad to narrow (8)Domain, Kingdom, Phylum, Class, Order, Family, Genus, Species124
66548104863 mechanisms in which bacteria transfer genetic materials1) Transformation: prokaryote takes up DNA from its environment 2) Transduction: viruses transfer genes between prokaryotes 3) Conjugation: genes are directly transferred from one prokaryote to another over a temporary "mating bridge"125
6654810487Types of Symbiotic RelationshipsMutualism (+, +), Commensalism (+, 0), Parasitism, (+, -)126
6654810488Factors that influence Transpiration RateTemperature: higher temperature, faster rate; Humidity: higher humidity, slower rate; Sunlight: more sun, faster rate; Wind: more wind, faster rate127
6654810489Lines of Immune Defense1st Line) skin oil and sweat, mucous; 2nd Line) nonspecific phagocytes and cytotoxic immune cells; 3rd Line) specific immune system128
6654810490Primary and Secondary Immune Response129
6654810491Active vs. Passive Immunitydepends on the response of a person's own immune system (artificial = vaccines) / immunity passed from one organism to another130
6654810492B cells vs. T cells (maturation)mature in bone marrow / mature in thymus131
6654810493Humoral vs. Cell-Mediated Immune Responses132
6654810494Non-steroid hormone vs. Steroid hormonetravels in bloodstream, binds to receptor on cell surface / travels in bloodstream, binds to receptor inside the cell133
6654810495Endotherms vs. Ectothermswarmed by heat generated by metabolism (mammals, birds) / generate little metabolic heat, warmed by environment134
6654810496Nichea position/role taken by a kind of organism within its community135
6654810497Resource Partitioningdivision of environmental resources by coexisting species136
6654810498Per capita Growth Ratebirth - death / total population137
6654810499Exponential vs. Logistic Growthin logistic growth, carrying capacity will limit the population's size138
6654810500Density-dependent RegulationDensity-independent: natural disasters, human impact, etc.139
6654810501Keystone Speciesspecies that exerts strong control on community structure not by numerical might but by their pivotal ecological roles or niches140
6654810502Energy Pyramideach energy level receives only 10% of the pervious level's energy141
6654810503Gross Primary Production vs. Net Primary Productiontotal amount of energy from light converted to chemical energy to organic molecules / GPP - energy used by primary producers for "autotrophic respiration"142
6654810504Carbon CycleConnect photosynthesis (fixation) to cellular respiration (CO2 release)143
6654810505Plasmidsa small, circular, double-stranded DNA molecule that carries accessory genes separate from those of a bacterial chromosome144
6654810506Recombinant DNAa DNA vector made in vitro with segments from different sources145
6654810507Restriction Enzymean enzyme that recognizes and cuts DNA molecules at specific nucleotide sequences (restriction sites), can then be used to create recombinant DNA146
6654810508Gel Electrophoresisanalyzing fragments of DNA (RFLPs) by their length and charge to determine genetic fingerprints and other genetic information147

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