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| 7217882075 | Disease | The most dramatic demographic effect of the Columbian exchange on the New World? | 0 | |
| 7217885145 | Pope's Rebellion (Pueblo Revolt) | The Spanish forcing religious practices on the Native Americans | 1 | |
| 7217890333 | Great Plains | Region that was home to bands of nomadic Native Americans who relied on their game for the vast majority of their needs | 2 | |
| 7217895353 | Iroquois | Tribe that was encountered by English settlers and best known for their highly evolved system of government? | 3 | |
| 7217899877 | Desire for more wealth | The initial motivation for Spanish exploration | 4 | |
| 7217901692 | Source of labor | How the Natives were viewed under the encomienda system | 5 | |
| 7217906441 | Bartolome de Las Casas | Protested treatment of Natives | 6 | |
| 7217909476 | Interdependent Global Economic System | Created with Columbus's discovery of the Americas | 7 | |
| 7217915039 | New World gain from the Columbian Exchange | Domesticated animals for food and beasts of burden | 8 | |
| 7217919506 | Old world gain from the Columbian Exchange | Growth of food supply | 9 | |
| 7217923138 | Mestizos | Created with the blending of Native and European Cultures | 10 | |
| 7217925088 | Conquistadors | Expanded Spain's colonial empire | 11 |
