Notable dates from unit five, from 527-1493.
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| 162114825 | 527-565 | Justinian, Eastern Roman (Byzantine) emperor (duration) | 0 | |
| 162114826 | 570-632 | Muhammad (duration) | 1 | |
| 162114827 | 589-618 | Sui Dynasty (China) (duration) | 2 | |
| 162114828 | 610-613 | Origins of Islam (duration) | 3 | |
| 162114829 | 618-907 | Tang Dynasty (duration) | 4 | |
| 162114830 | 634-750 | Arab invasions in Middle East; spread of Islam in North Africa (duration) | 5 | |
| 162114831 | 661-750 | Umayyad Caliphate (duration) | 6 | |
| 162114832 | 668 | Korea becomes independent from China (year) | 7 | |
| 162114833 | 711 | First Islamic attack in India (year) | 8 | |
| 162114834 | 718 | Byzantines defeat Arab attack on Constantinople (year) | 9 | |
| 162114835 | 750 | Abbasid Caliphate (year) | 10 | |
| 162114836 | 777 | Independent Islamic kingdoms begin in North Africa (year) | 11 | |
| 162114837 | 800-814 | Charlemagne Empire in western Europe (duration) | 12 | |
| 162114838 | 855 | Russian kingdom around Kiev (year) | 13 | |
| 162114839 | 864 | Cyril and Methodius missionaries in eastern Europe (year) | 14 | |
| 162114840 | 878 | Last Japanese embassy to China (year) | 15 | |
| 162114841 | 960-1127 | Song Dynasty (China) (duration) | 16 | |
| 162114842 | 968 | Tula established by Toltecs (Mesoamerica) (year) | 17 | |
| 162114843 | 980-1015 | Conversion of Vladimir I of Russia (duration) | 18 | |
| 162114844 | 1000 | Ghana Empire at its height (Africa) (year) | 19 | |
| 162114845 | 1054 | Schism between Eastern and Western Christianity (year) | 20 | |
| 162114846 | 1055 | Seljuk Turks control Abbasid caliphate (year) | 21 | |
| 162114847 | 1066 | Norman conquest of England; rise of feudal monarchy in Western Europe (year) | 22 | |
| 162114848 | 1096-1099 | First Christian Crusade to Palestine (duration) | 23 | |
| 162114849 | 1100 | Invention of explosive powder (China) (year) | 24 | |
| 162114850 | 1150 | Disintegration of Toltec Empire (year) | 25 | |
| 162114851 | 1150-1350 | Spread of Gothic style; scholasticism in Western Europe (duration) | 26 | |
| 162114852 | 1185-1333 | Kamakura Shogunate (Japan) (duration) | 27 | |
| 162114853 | 1200 | Rise of empire of Mali (year) | 28 | |
| 162114854 | 1206 | Delhi sultanate in India (year) | 29 | |
| 162114855 | 1231-1392 | Mongols rule Korea (duration) | 30 | |
| 162114856 | 1236 | Capture of Russia by Mongols (year) | 31 | |
| 162114857 | 1258 | Capture of Baghdad by Mongols; end of Abbasid caliphate (year) | 32 | |
| 162114858 | 1260 | Death of Sundiata (Mali) (year) | 33 | |
| 162114859 | 1265 | Fist English parliament (year) | 34 | |
| 162114860 | 1279-1368 | Mongol Empire in China (duration) | 35 | |
| 162114861 | 1290s | Islam begins to spread to southeast Asia (decade) | 36 | |
| 162114862 | 1320s | Europeans first use cannon in war (decade) | 37 | |
| 162114863 | 1320-1340 | Bubonic plague breaks out in Gobi desert and spreads to other parts of Asia (duration) | 38 | |
| 162114864 | 1325 | Rise of Aztec Empire (year) | 39 | |
| 162114865 | 1338-1453 | Hundred Years' War in Europe (duration) | 40 | |
| 162114866 | 1350 | Rise of Incas (Andes) (year) | 41 | |
| 162114867 | 1392-1910 | Yi dynasty (Korea) (duration) | 42 | |
| 162114868 | 1400 | End of Polynesian expeditions (year) | 43 | |
| 162114869 | 1405-1433 | Chinese trading expeditions (duration) | 44 | |
| 162114870 | 1439 | Portugal acquires Azores (year) | 45 | |
| 162114871 | 1453 | Turks capture Constantinople; end of Byzantine Empire (year) | 46 | |
| 162114872 | 1471-1493 | Peak of Inca Empire (duration) | 47 |
