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B12 absorption Flashcards

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59992278731Parietal cells synthesize intrinsic factor (IF) and hydrochloric acid (HCl) Gastric acid converts pepsinogen to pepsin. Pepsin frees vitamin B 12 from ingested proteins.0
59992278742Free vitamin B 12 binds to R-binders (haptocorrins) synthesized in salivary glands. Protects vitamin B 12 from acid destruction1
59992397353Pancreatic enzymes in the duodenum cleave off the R-binders. Vitamin B 12 binds to IF to form a complex.2
59992397374Vitamin B 12 -IF complex is absorbed in the terminal ileum.3
59992415825Vitamin B 12 binds to transcobalamin II and enters the plasma. Delivered to metabolically active cells or stored in the liver (6- to 9-year supply)4
5999482203What is the role of parietal cells in B12 absorption?The parietal cells produce intrinsic factor (IF), which is required for B12 absorption in the terminal ileum. A lack of parietal cells results in a lack of intrinsic factor and, therefore, a B12 deficiency5
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