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Biochemistry a short course Chapter 10 Flashcards

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3088421638Carbohydrates Empirical Formula(CH2O)n0
3088424332Carbohydrate functions1)Energy Storage (NOT THE MAIN ONE) 2)Cell to Cell Signaling1
3088428991Covalent bonds much more varied for carbs. Therefore, what does this imply?Vast array of 3-D structures and a variety of isomeric forms2
3088430159Monosaccharides nomenclatureAldehydes=Aldoses Ketone=Ketoses Example=D-Fructose is the most abundant ketohexose3
3088435699Proteins use L isomers while sugars use...D isomers4
3088436157EpimersMolecules that differ in configuration at only one chiral carbon5
3088445825In solution the which form of sugar dominates?Cyclic6
3088450868Six-membered RingPyranose7
3088451534Five-membered RingFuranose8
3088452280alpha vs. beta configurationsAlpha=down Beta=up9
3088453571Monosaccharidesaldehydes or ketones that have two or more hydroxyl groups. Smallest ones have atleast three carbons10
3088455763Reducing Sugar-Can reduce other molecules and therefore are oxidized. -In open form have an aldehyde group -Fructose is a non-reducing sugar11
3088460734Advanced glycation end products(AGEs)Binding of sugars to proteins that have been implicated in pathological conditions12
3088464568Anomeric Carbon bound to AlcoholGlycosidic or O-glycosidic bond13
3088465781Anomeric Carbon bound to AmineN-glycosidic bond14
3088466331Oligosaccharideslink tow or more sugars through O-glycosidic bonds15
3088467507Glycosyltransferases-catalyze glycosidic bond formation on any of the hydroxyl groups on sugar -Lots of hydroxyl groups =>diversity of bonds=>Different enzymes needed to make different bonds -1to2% of the genome16
3088473312UDP-Glucoseactivated sugar nucleotide that has energy needed to form a glycosidic bond.17
3088475150Glucosinolates-Special class of glycosides in plants -Hydrolyzed into isothiocynate which is bitter -Discourages herbivory18
3088478146Sucrose-alpha-Glucose to beta-Fructose19
3088479366Lactose-Galactose to Glucose -Beta 1to4 glycoside20
3088494760Maltose-Glucose to Glucose -Alpha 1 to 4 glycoside21
3088498876Glucose-Reducing Sugar -Down, Up, Down22
3088499794Fructose-Non-reducing sugar -Up, down23
3088501258Galactose-Reducing Sugar -Down, Up, Up24
3088504218PolysaccharidesLarge polymeric oligosaccharides25
3088504789HomopolymerPolymer made up of same monomer26
3088505703Glycogen-Common in muscle and liver -Main strand is alpha 1 to 4 glycosides -Branching is alpha 1 to 6 -Forms hollow helix that allows more compact storage and easier access for enzymes27
3088510850Starch-Nutritional reservoir in plants -Amylose -Amylopectin -Hydrolyzed by alpha-amylase28
3088512293Amyloseunbranched alpha-(1,4) glycosides29
3088520547Amylopectin-Branched at every thirty units -alpha (1to4) linkages -alpha (1to6) linkages30
3088524048Cellulose-Most abundant organic compound in Biosphere -Long chains interact through H-bonding to generate rigid, supportive structure -High tensil strength -Beta (1to4) linkages31
30885302823 classes of glycoproteins1)Glycoproteins 2)Proteoglycans 3)Mucins32
3088530931Glycoproteins-Mainly protein -Part of cell membranes for cell adhesion/interaction -Most proteins in serum are glycosylated33
3088532764Proteoglycans-Mainly Carbs -Protein conjugated to a glycosaminoglycan -Structural components and Lubricants34
3088539601Mucins-Mostly Carbs. -Proteins usually bound to N-acetylgalactosamine35
3088542822All N-linked glycoproteins have what?Pentasaccharide core consisting of 3 mannoses and 2 N-Acetylglucosamines -Additional sugars attach to this core to form variety of oligosaccharides36
3088547764Erythropoietin-Stimulates RBC count -Glycoprotein -Stabilized by Glycosylation -Glycosylation is unique to the organism that produced it.37
3088553333Proteoglycans-Bound to glycosaminoglycans which determine its properties. -Lubes and structures. -Mediate adhesion of cells -Bind factors that regulate cell proliferation38
3088557063Glycosaminoglycans-Repeating units of disaccharides(either glactosamine or glucosamine) -One of the two sugars has carboylate or sulfate group -Hyaluronate -Chondrotien -Chitin39
3088560559Mucopolysaccharidosesdiseases from inability to degrade glycosamionglycans40
3088583061Aggrecans-shock absorber that are linked by hyaluronate(a glycosaminoglycan) -Water absorbs into hyaluronate improving cushioning41
3088586747Chitin-Glycosaminoglycan found in exoskeleton -second most abundant polysaccharide42
3088588124MucinsForm large polymeric structures -Abundant in saliva -Function as lubricants43
3088589808Defining feature of mucinsVariable number of tandem repeats(VNTR) -rich in serine and threonine residues that are O-glycosylated44
3088592558O-Antigen-Common oligosaccharide foundation for other blood antigens45
3088593797A-AntigenAddition of one N-acetyl galactosamine46
3088596574B-AntigenAddition of one galactose47
3088596917Why different blood types?Variety means protection from diseases48
3088598501I-cell diseaseslysosomal storage disease -Enzymes not tagged correctly=>end up in blood -Have no mannose-6-phosphate on enzyme49
3088601286Glycan-binding proteinsbind specific carb structure on neighboring cells -Lectin50
3088603118Lectins-facilitate cell to cell interactions. -Contain two or more carb-binding sites -Link carbs via weak interactions51
3088606148Selectins-Type of lectins -Bind to immune system cells to sites of injury in inflammatory response52
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