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Cellular communication/ Signal transduction (Chapter Eleven) Flashcards

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3330980368Signal Transduction PathwaySeries of steps linking a mechanical, chemical or electoral stimulus to a specific cellular response0
3330999265Paracrine Signaling-Animal cells communicate using secreted messenger molecules -Travel only short distances -Ex: Growth Factors1
3330999266Synaptic SignalingOccurs in animals nervous system when a neurotransmitter is released in response to electric signal2
3331001747Endocrine Signaling-When specialized cells release hormones which travels target cells via the circulatory system -Form of hormonal signaling -Travels long distances3
3331032928Three Stages of Cell Signaling1) Reception 2) Transduction 3) Response4
3331064549LigandA molecule that specifically binds to another molecule, often times a larger one -Signaling molecule acts as a ligand -Ligand binding causes a receptor protein to change shape5
3331073367G -protein coupled receptors (GPCR's)-Largest family of cell-surface receptors -cell surface transmembrane receptors that work with the help of a G protein -G proteins bind energy rich GTP6
3331096901Receptor Tyrosine Kinases (RTK's)-Membrane receptors that attach phosphates to tyrosines -Can trigger multiple signal transduction pathways at once7
3331107472Ligand-gated Ion Channel-Receptor that acts as a gate when the receptor changes shape -This "gate" allows certain ions through such as Na+ or Ca2+8
3331123639Explain how Steroid Hormones change Target cells-Enter the cell and bind to an intercellular-receptor protein ----> making it a hormone receptor complex -This complex is able to cause a response by turning on or off particular genes9
3331130447Transcription FactorSpecial proteins that control what genes are turned on10
3331159913Phosphorylation Cascade-Series of different proteins in a pathway are phosphorylated in turn -Each protein adding a phosphate group to the next one in line11
3331159914Function of Protein KinasesTransfer phosphates from ATP to Protein (Phosphorylation)12
3331162231Function of Protein PhosphatesRemove the phosphates from the proteins (dephosphorylation)13
3331199013Second Messenger-Small, nonprotein, water-soluble molecules or ions that spread throughout a cell by diffusion -Take part in pathways initiated by GCPRs and RTKs14
3331199014Role of cAMP in signaling- cAMP= Cyclic AMP -This and calcium ions are common second messengers -Activates protein kinase A15
3331200367Protein Kinase A-Phosphorylates other proteins -Activated by cAMP16
3331245123Advantages to multi-step transduction pathway?Two main Advantages 1) Amplifying the Signal : At each step the number of activated products is much greater than in the preceding step 2) Contributing to the specificity of the Response17
3331277738ApoptosisProgrammed or controlled cell suicide -Used during shaping of an organism during embryonic development18

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