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Ch 16 Molecular Inheritance Flashcards

Campbell

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346742055James WatsonUnited States geneticist who (with Crick in 1953) helped discover the helical structure of DNA (born in 1928)0
346742056Francis Crickdiscovered the secret of DNA structure in the 1950s with James Watson using Rosalind Franklin's pictures of DNA1
346742057Rosalind Franklincarried out the X-ray crystallography analysis of DNA and showed DNA is a helix2
346742058Griffithscientist who experimented with bacteria to find out how it made people sick. Discovered process of transformation.3
346742059Avery, McCarty and MacLeod1944- repeated portions of Griffith's experiment -used only heat-killed bacteria -purified all chemicals from cells -added each independently* to live cells -ONLY DNA acted as transforming agent4
346742060Hershey and ChaseUsed radioactive material to label DNA and protein; infected bacteria passed on DNA; helped prove that DNA is genetic material not proteins5
346742061Chargaffdiscovered that the amount of adenine equals the amount of thymine, and amount of guanine equals cytosine?6
346742062transformationmodification of a cell or bacterium by the uptake and incorporation of exogenous DNA7
346742063bacteriophagesviruses that infect bacteria8
346742064double helixtwo strands of nucleotides wound about each other; structure of DNA9
346742065semiconservative modelType of DNA replication in which the replicated double helix consists of one old strand, derived from the old molecule, and one newly made strand.10
346742066origins of replicationSites where the replication of a DNA molecule begins.11
346742067replication forksthe areas where the double helix separates12
346742068polymerasesDNA is transcibed by these enzymes. Make RNA polymers13
346742069leading strandthe new continuous complementary DNA strand synthesized along the template strand in the mandatory 5' --> 3' direction14
346742070lagging strandA discontinuously synthesized DNA strand that elongates in a direction away from the replication fork.15
346742071DNA ligasean enzyme that eventually joins the sugar-phosphate backbones of the Okazaki fragments16
346742072primaseAn enzyme that joins RNA nucleotides to make the primer.17
346742073primerAn already existing RNA chain bound to template DNA to which DNA nucleotides are added during DNA synthesis.18
346742074helicasesenzymes that separate the DNA strands19
346742075single strand binding proteinDuring DNA replication, molecules that line up along the unpaired DNA strands, holding them apart while the DNA strands serve as templates for the synthesis of complementary strands of DNA.20
346742076mismatch paira situation in which enzymes remove and replace incorrectly paired nucleotides that have resulted from replication errors21
346742077nucleotide excision repairThe process of removing and then correctly replacing a damaged segment of DNA using the undamaged strand as a guide.22
346742078nucleasegeneral term for enzymes that catalyze the hydrolysis of nucleic acid by cleaving chains of nucleotides into smaller units23
346742079telomeresRepeated DNA sequences at the ends of eukaryotic chromosomes.24
346742080telomerasean enzyme in eukaryotic cells that can add telomeres to the ends of chromosomes after they divide25
346742081Okazaki fragmentsShort fragments of DNA that are a result of the synthesis of the lagging strand during DNA replication.26

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