Terms : Hide Images
| 11038314984 | What is genomics? | It is the study of the entire genome. | 0 | |
| 11038321287 | What is structural genomics? | It focuses on sequencing entire genomes by analysing nucleotide sequences to identify genes and sequences. | 1 | |
| 11038344016 | What is whole-genome sequencing (WGS)? | It is a method used for sequencing and assembly of entire genomes, genomic DNA is cut into fragments and contigs are made to be reassembled by algorithm-based softwares that aligns DNA for comparison of sequence. | 2 | |
| 11038369387 | What is the clone-by-clone approach? | It is a method used where DNA is fragmented from restriction enzymes creating a restriction map of the chromosome. The fragments are then ligated into vectors and contigs are sequenced and aligned to assemble the entire chromosome. | 3 | |
| 11038386858 | What is compiling? | It is the step after the fragments are ligated, and a decision is made to designate the ligated sequence as final. | 4 | |
| 11038397606 | What is basic local alignment search (BLAST)? | It is a search tool which assists in comparison of a segment of genomic DNA to sequences found in major databases. | 5 | |
| 11038412022 | How can BLAST be useful in genomic studies? | A discovered sequence can be compared to sequences on databases and BLAST will tell you the similarity between the discovered sequence and stored sequence on GenBank. If the stored sequence has a known function, and there are high similarities between your sequence found and the stored sequence we can determine the function of the newfound sequence. | 6 | |
| 11038447110 | What are protein-coding regions? | They are annotation of sequences that reveals certain identifiable features, e.g. promoter sequence, initiation sequence and exons. | 7 | |
| 11038459366 | What are open reading frames (ORFs)? | It is another sequence identifiable by annotation that searches for triplet nuclear types that can be translated into an amino acid sequence of a proteinm e,g. ATG (start codon), TAA, TAG, TGA (termination sequences). | 8 | |
| 11038469608 | What is annotation? | It is when the genome is assembled and sequences are compiled, annotation is used to understand the roles and functions of the specific gene. | 9 | |
| 11038493568 | What is functional genomics? | It is the study of function of jeans based on resulting RNAsImpossible proteins encoded. | 10 | |
| 11038512835 | How do we predict a function in functional genomics? | Blast searches can be done or similarities searches using databases with already identified functions to compare sequence of interest. | 11 | |
| 11038533595 | What are homologous genes? | They are jeans that are evolutionarily related. Orthologs: are genes from a different species that descended from a common ancestor e.g. Mouse and human LEP gene - Same gene present in two different species. Para logs: genes homologous within the same species | 12 | |
| 11038588897 | How does alternative splicing produce diversity in proteins? | One gene can produce multiple proteins depending on where splicing occurs and what genes get recombined. | 13 | |
| 11038796188 | What is bioinformatics? | It is the application of computer based methods used to organise, share and analyse data related to gene structure, sequences, expressions and also protein structure and function. | 14 | |
| 11038799700 | What is transcriptomics? | It is the study of the entire mRNA in a sample and studies the expression of genes qualitatively and quantitatively. Qualitative study identifies which genes are expressed and which aren't, quantitative study measures the varying levels of expression of different genes. | 15 | |
| 11038799701 | What is comparative genomics? | It is the study of comparing genomes of different organisms to answer questions about genetics and other aspects of biology e.g. between Humans and Chimpanzees, or Humans and Neanderthals. | 16 | |
| 11038799702 | What is proteomics? | It is the study of proteins that identifies, characterises and quantitatively analyses them from the genome of a cell, tissue or organism. | 17 | |
| 11038804311 | What is systems biology? | It incorporates data from genomics, transcriptomics, proteomics and other biology areas and interpret the genomic information in context of structure, function and regulation e.g. muscular, metabolic, neurological etc. | 18 |
