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Intro to Nervous system and neural development Flashcards

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6058246114Caudaltoward the tail0
6058252680Ipsilateralon the same side1
6058258501rostraltoward the nose2
6058270400if something is 'medially' located it istoward the middle or the spine3
6058277856synonym for anteriorrostral4
6058280232synonym for posteriorcaudal5
6058295306synonym for superior (in brain view)dorsal (upper side)6
6058300588synonym for inferior (in brain view)ventral (lower side)7
6058311678Coronal planegives a vertical plane from dorsal to ventral, separating caudal and rostral parts of brain Figure 3.2, page 698
6058345811Horizontal planegives a horizontal plane from caudal to rostral separating the dorsal and ventral parts of the brain Figure 3.2, page 699
6058366689CNS (central nervous system) is composed ofspinal cord and brain10
6058372139PNS (periferal nervous system) includes(SNS) sensory - somatic nervous system and the (ANS)Autonomic nervous system11
6058383406Autotonomic nervous system includes two parts:sympathetic and parasympathetic nervous systems12
6058422591Central nervous system - is the core protected by...skull and spinal cord - contains cell nuclei13
6058437359Peripheral nervous system -Parts of the cells that reach out to the periphery of the body and receive or send signals14
6058444569Cranial nervespart of the peripheral nervous system (PNS)that enter the CNS through the skull15
6058453169Other cells in the PNS enter the CNS :through the spinal cord16
6058459129Sensory (somatic) nervous system. (think 'senses')Part of the PNS (mostly voluntary) that communicates and responds to the organisms external environment (touching a hot stove! )17
6058467741Autonomic nervous system(ANS) (- think 'automatic'controls( mostly involuntary) internal vital processes like digestion, heart rate, respiration, hormone secretion18
6058480597Sympathetic and parasympathetic Nervous systempart of the Autonomic nervous system (ANS)19
6058508810Afferent nervescoming into the CNS20
6058510766Efferent nervesgoing out to the muscles21
6058512633Define 'Ganglion' (part of nerve cell)A group of nerve cells forming a nerve center, especially one located outside the brain or spinal cord.22
6058537527Define 'Soma' (part of a nerve cell)or "cell body" is the bulbous, non-process portion of a neuron or other brain cell type, containing the cell nucleus. The word "soma" comes from the Greek σῶμα, meaning "body".23
6058546059how many cranial nerves are there?12 carnial nerves - enter through the skull (your should memorize these slide 10)24
6058561987First 3 cranial nervesOlfactory, optic, and ocularmotor25
6058566311cranial nerves 4 through 7trochlear, trigenminal, abducens, facial26
6058572257cranial nerves 8 and 9 ( a mouthful!)vestibulocochlear, glossopharyngeal27
6058584393cranial nerves 10 through 12vagus, spinal accessory, hypoglossal (STUDY SLIDE 10)28
6058599548Examples of parasympathetic nerve functionsconstricts pupils, slows heart, stimulates erection:-)29
6058607101Examples of sympathetic nerve functionsdialates pupils, increases heart rate, restricts urination , stimulates epinephrine (fight or flight responses)30
6058626763approximate mass of human brain?1200 to 1500 grams31
6058629561% of blood flow (oxygen)that goes to the Brain?20% !!!but its only 2% of the total body mass! Lots of calories go to make brain work32
6058640044What side of the body does the right hemisphere of the brain controlthe left side33
6058650254the name of the non-nerural tissue that protects and surrounds the brainMeninges34
6058652406How many layers of meninges surround the brain?3 layers35
6058657552what are the 3 meningeal layers surrounding the brain called?Dura, arachnoid and pia matter36
6058667020CSF (cerebral spinal fluid)fluid constantly made and surrounds the brain (in the subarachnoid space between arachnoid and pia mater)37
6058681476ventricular system in the brainin the center of the brain (and produces the cerebral spinal fluid (CSF) that protects the brain (learn parts !!)38
6058705855Nervous system development startsabout 3 weeks after fertilization and after the gastrula stage (slide 15 ) a neural plate forms <-- first part of nerve system39
6058729113After gastrulation the ectoderm becomes:Epidermins, CNS, PNS (slide 16)40
6058731330After gastrulation the mesoderm (middle layer) becomes:Kidneys liver, bones, , vascular, reproductive system41
6058742093After gastrulation the endoderm (inside) becomes:Intestines, lungs and liver42
6058760101Define neurulation:a neural groove forms and then closes making a neural tube which will develop into brain and spinal cord43
6058773088the most common neurological problems in developing babies:neural tube defects during the closing44
6058776102Name 3 neural tube defects?Anencephaly, Encephaloceles , Myelomeningocel45
6058782964Most common of the 3 neural tube defects is:Myelomeningocel - the backbone and spinal canal do not close before birth; paralyzed limbs, bowel and urinary dysfunction, excess fluid in the brain, intellectual disabilities46
6058792711EncephalocelesA neural tube defect: having sac-like protrusions of the brain and the membranes that cover it.47
6058797670Anencephalybeing born with little or no brain48
6058804925Differentiation ( of major parts of brain)4th week of gestation - the neural tube divides into three primary vesicles (bulges).49
6058811700Names of the primary vesicles in brain development are:prosencephalon (forebrain) mesencephalon (midbrain) rhombencephalon (hindbrain)50
6058817057Which part of the primary vesicle structures will become the spinal cord?behind the rhombencephalon, the neural tube continues; this part will produce the spinal cord51
6058822048Proliferationformation of major parts of the brain ,7th week - 5 main structures52
60588295435 main structures of the brain formed in Proliferation:Telencephalon (anterior forebrain) Diencephalon (posterior forebrain) Mesencephalon (midbrain) Metencephalon (rostral hindbrain) Myelencephalon (caudal hindbrain) (study slide 19)53
6058839849the telencephelon becomes:cerebral cortex basal telencephalon (basal ganglia) olfactory bulb and limbic system54
6058843859the diencephelon becomes:thalamus hypothalamus55
6058850139Lateral and third ventricles are formed in between:the telencephalon and the diencephalon (third ventricle forms in the space at the center of the diencephalon56
6058862360the mid-brain (mesencephelon) contains the:tectum and tegmentum (and cerebral aquaduct)57
6058872722also in the mid-brain(and hind brain):the rostral portion of the hind brain differentiates into cerebellum and pons58
6058877194Central canal (mesencephalon) becomesthe fourth ventricle59
6058890209List 3 processes allow stem cells to transform into full blown nerve cells?1) proliferation (make a bunch of cells 2) determination (cell fate gets decided) 3) migration and differentiation (neurons migrate to final destination and make all the final connections that allow them to function60
6058907403Axons and dendrites form in nerve cells when:the cell has migrated to its final destination61
6058911477How do axons find their specific target cells?select correct route find the right target connect at the correct final destination (magic?)62
6058920071"growth cone" of an axonzone at the tip of axon sensitive to chemical signals that determine direction and elongation of axon63
60589301063 types of molecules direct development of "growth cone"cell adhesion molecules (CAMs), chemotropic factors , trophic factors64
6058935449cell adhesion molecules (CAMs)non-diffusable- attached to various substrates along the growth cone's path; recognized by specific receptors on the growth cone's membrane65
6058935450chemotropic factorssecreted by the target cells, into the surrounding extracellular environment - guide the growth cone via: chemoattraction chemorepulsion66
6058937203trophic factorsdo not provide guidance signals as such but are necessary for the elongation of the axon; role in the formation of synaptic connections67
6058952639Embryos only produce as many neurons as needed (true or false?)false they produce 2 to 3 times more68
6058955048What causes some neurons to live and others to die?trophic factors!!! ensure axon survival once it has formed certain functional synaptic connections; they are secreted in limited amounts by the target cells, so that only a subset of the neurons that innervate them receive enough to survive69
6058959859what happens to neurons that dont get enough trophic factors?they die = Neuronal death70
6058963588Define apoptosis:Bodies programmed cell death71
6058967112Define necrosis:accidental cell death72
6058970023Name some neurodevelopmental abnormalities/atypicalitiesFetal Alcohol Syndrome (FAS) - caused by the ingestion of alcohol during pregnancy, especially during the 3rd to 4th week (Sulik, 2005) - Autism spectrum disorders (ASD) Schizophrenia Affective Disorders73
6058975671How does FAS result in neurodevelopmental abnormalities?alcohol interferes with cell adhesion molecules74
6058979347What causes Autism spectrum disorders (ASD)apoptosis Increased local connectivity (short-range axons), but decreased long-range connectivity "Extreme male brain" theory of autism75
6058988984What may cause Schizophrenia?- influenza + possibly rubella, toxoplasmosis, toxins etc. most vulnerable period -2nd trimester apoptosis - excessive prunning? paternal age76
6058995428What may cause affective disorders?e.g., Dome et al. (2010) - seasonality effect (summer)??77

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