[Click Info tab for entire description] Hello! This is my set about the Krebs Cycle, by Fadil Nohur, aka fiddle_n. The Krebs cycle is also known as the TCA cycle or the Citric Acid cycle. It is called the Krebs cycle after Hans Adolf Krebs, the guy who discovered it. When it is called the TCA cycle, TCA stands for tricarboxylic acid cycle. Citric acid, isocitric acid and aconitic acid are all tricarboxylic acids, and their conjugate bases, citrate, isocitrate, and cis-aconitate, are all in this cycle. This also explains why this cycle is sometimes called the Citric Acid cycle. The Krebs cycle/TCA cycle/Citric Acid cycle is difficult to learn, so I hope this set helps. Oh, and if you like my set, please feel free to give me a high five! :)
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| 1888778971 | (Step 1) Acetyl CoA + Oxaloacetate → Citrate is catalysed by | Citrate synthase | 0 | |
| 1888778972 | (Step 1) Acetyl CoA + Oxaloacetate → Citrate produces | CoA | 1 | |
| 1888778973 | (Step 1) Acetyl CoA + Oxaloacetate are condensed to produce | Citrate | 2 | |
| 1888778974 | (Step 2A) Citrate → cis-Aconitate is catalysed by | Aconitase | 3 | |
| 1888778975 | (Step 2A) Citrate is dehydrated to produce the intermediate compound | cis-Aconitate | 4 | |
| 1888778976 | (Step 2A) Is H₂O added or removed in the Citrate → cis-Aconitate reaction? | Removed | 5 | |
| 1888778977 | (Step 2B) cis-Aconitate → Isocitrate is catalysed by | Aconitase | 6 | |
| 1888778978 | (Step 2B) cis-Aconitate is hydrated to produce | Isocitrate | 7 | |
| 1888778979 | (Step 2B) Is H₂O added or removed in the cis-Aconitate → Isocitrate reaction? | Added | 8 | |
| 1888778980 | (Step 3) Isocitrate → α-Ketoglutarate is catalysed by | Isocitrate dehydrogenase | 9 | |
| 1888778981 | (Step 3) Isocitrate and NAD⁺ → NADH + CO₂ (oxidative decarboxylation) leads to | α-Ketoglutarate | 10 | |
| 1888778982 | (Step 3) Isocitrate → α-Ketoglutarate half reaction? | NAD⁺ → NADH | 11 | |
| 1888778983 | (Step 3) What is produced in the Isocitrate → α-Ketoglutarate reaction? | NADH and CO₂ | 12 | |
| 1888778984 | (Step 4) α-Ketoglutarate → Succinyl CoA is catalysed by | α-Ketoglutarate dehydrogenase complex | 13 | |
| 1888778985 | (Step 4) α-Ketoglutarate and CoA + NAD⁺ → CO₂ + NADH (oxidative decarboxylation) leads to the energy rich | Succinyl CoA | 14 | |
| 1888778986 | (Step 4) What are added into the α-Ketoglutarate → Succinyl CoA reaction? | NAD⁺ and CoA | 15 | |
| 1888778987 | (Step 4) What are removed from the α-Ketoglutarate → Succinyl CoA reaction? | NADH and CO₂ | 16 | |
| 1888778988 | (Step 5) Succinyl CoA → Succinate is catalysed by | Succinyl CoA synthetase | 17 | |
| 1888778989 | (Step 5) Succinyl CoA → Succinate produces what two things? | CoA and GTP | 18 | |
| 1888778990 | (Step 5) Succinyl CoA undergoes substrate-level phosphorylation to produce | Succinate | 19 | |
| 1888778991 | (Step 6) Succinate → Fumarate is catalysed by | Succinate dehydrogenase | 20 | |
| 1888778992 | (Step 6) Succinate and FAD → to FADH₂ (Dehydrogenation) produces | Fumarate | 21 | |
| 1888778993 | (Step 6) Succinate → Fumarate half reaction? | FAD → FADH₂ | 22 | |
| 1888778994 | (Step 7) Fumarate → Malate is catalysed by | Fumarase (Fumarate hydratase) | 23 | |
| 1888778995 | (Step 7) Fumarate is hydrated to produce | Malate | 24 | |
| 1888778996 | (Step 8) Malate → Oxaloacetate is catalysed by | Malate dehydrogenase | 25 | |
| 1888778997 | (Step 8) Malate and NAD⁺ → NADH (Dehydrogenation) produces | Oxaloacetate | 26 | |
| 1888778998 | (Step 8) Malate → Oxaloacetate half reaction? | NAD⁺ → NADH | 27 | |
| 1888778999 | Which step does CoA get removed from? (Step 1) | Acetyl CoA + Oxaloacetate → Citrate | 28 | |
| 1888779000 | Which step does H₂O get removed from? (Step 2A) | Citrate → cis-Aconitate | 29 | |
| 1888779001 | Which step does H₂O get added into? (Step 2B) | cis-Aconitate → Isocitrate | 30 | |
| 1888779002 | Which step does NAD⁺ get added into, and CO₂ and NADH get removed from? (Step 3) | Isocitrate → α-Ketoglutarate | 31 | |
| 1888779003 | Which step does CoA and NAD⁺ get added into, and CO₂ and NADH get removed from? (Step 4) | α-Ketoglutarate → Succinyl CoA | 32 | |
| 1888779004 | Which step does CoA get removed from? (Step 5) | Succinyl CoA → Succinate | 33 | |
| 1888779005 | Which step produces GTP? | Succinyl CoA → Succinate | 34 | |
| 1888779006 | Which step produces FADH₂ from FAD? | Succinate → Fumarate | 35 | |
| 1888779007 | Which step does H₂O get added into? (Step 7) | Fumarate → Malate | 36 | |
| 1888779008 | Which step does NAD⁺ → NADH occur? (Step 8) | Malate → Oxaloacetate | 37 | |
| 1888779009 | Purpose of Krebs cycle? | Provide reducing power | 38 | |
| 1888779010 | Overall function of Krebs cycle? | Oxidise 2 carbon atoms of Acetyl CoA to CO₂ | 39 | |
| 1888779011 | Produces how many CO₂? | 2 | 40 | |
| 1888779012 | Produces how many NADH? | 3 | 41 | |
| 1888779013 | Produces how many FADH₂? | 1 | 42 | |
| 1888779014 | Produces how many ATP/GTP? | 1 | 43 | |
| 1888779015 | Name a silly mnemonic to help you remember the Krebs cycle? | Can I Keep Selling Sex For Money, Officer? (Citrate, Isositrate, Alpha-Ketoglutarate, Succinyl CoA, Succinate, Fumarate, Malate, Oxaloacetate) | 44 |
