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Lehninger Biochemistry - Ch. 1 Flashcards

The Foundation of Biochemistry

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3692189904Distinguishing features of living organisms.1. High degree of complexity 2. Systems for using energy 3. Defined functions for each component 4. Mechanisms for sensing and responding 5. A capacity for precise self-replication and assembly 6. A capacity to change over time0
3692189905Three Domains1. Archaea 2. Bacteria 3. Eukarya1
3692189906BacteriaInhabit soils, surface waters, and tissues.2
3692189907ArchaeaInhabit extreme environments; salt lakes, hot springs and the ocean.3
3692189908Aerobic EnvironmentsOrganisms derive energy from the transfer of electrons from fuel molecules to oxygen.4
3692189909Anaerobic EnvironmentsOrganisms obtain energy by transferring electrons to nitrate (forming N2), sulfate (forming H2S), or CO2 (forming CH4). (Many of these organisms die when exposed to oxygen).5
3692189910PhototrophsEnergy from light. Autotroph - Carbon from CO2 Heterotroph - Carbon from organic compounds6
3692189911ChemotrophsEnergy from oxidation of a fuel. Lithotrophs - Oxidize inorganic fuels (Fe2+ to Fe3+). Organotrophs - Oxidize organic compounds.7
3692189912Monomeric UnitsNucleotides Amino Acids Sugars8
3692189913MacromoleculesDNA Protein Cellulose9
3692189914Supramolecular ComplexesChromatin Plasma Membrane Cell Wall10
3692189915CarbonSingle bonds with Hydrogen Single or double bonds with Nitrogen and Oxygen11
3692189916MethylH l R-C-H l H12
3692189917EthylH H l l R-C-C-H l l H H13
3692189918Carbonyl (aldehyde)R-C-H ll O14
3692189919Carbonyl (ketone)R1-C-R2 ll O15
3692189920CarboxylR-C-O` (`is minus) ll O16
3692189921HydroxylR-O-H17
3692189922EtherR1-O-R218
3692189923EsterR1-C-O-R2 ll O19
3692189924AcetylH l R-O-C-C-H ll l O H20
3692189925ProteinsLong polymers of amino acids.21
3692189926ProteomeSum of all the proteins functioning in a cell.22
3692189927Nucleic AcidsPolymers of DNA and RNA.23
3692189928PolysaccharidesPolymers of simple sugars (IE glucose)24
3692189929StereoisomersMolecules with the same chemical bonds but different configuration.25
3692189930StereospecificRequiring specific configurations in the interacting molecules.26
3692189931Geometric Isomers (Cis-Trans Isomers)Differ in the arrangement of the substituent groups with respect to the nonrotating double bond.27
3692189932Chiral CenterCarbon atom with 4 substituents that is said to be asymmetric.28
3692189933EnantiomersStereoisomers that are mirror images of each other.29
3692189934DiastereomersPairs of stereoisomers that are not mirror images of each other.30
3692189935RS System - RDetermined clockwise.31
3692189936RS System - SDetermined counter-clockwise.32
3692189937IsolatedSystem exchanges neither matter nor energy with its surroundings.33
3692189938ClosedSystem exchanges energy but not matter with its surroundings.34
3692189939OpenSystem exchanges both energy and matter with its surroundings.35
3692189940Oxidation-Reduction ReactionsOne reactant is oxidized (loses E-) and one is reduced (gains E-).36
3692189941Entropy (S)Randomness or disorder of the components of a chemical system.37
3692189942Enthalpy (H)Number and kinds of bonds.38
3692189943Temperature (T)Kelvin (C + 273.15)39
3692189944ΔChange40
3692189945Free-Energy Change (ΔG)ΔG = ΔH - TΔS ΔH is negative for a rxn that releases heat; ΔS is positive for a rxn that increases the systems randomness. ΔG is negative for a rxn that occurs occurs spontaneously.41
3692189946EndergonicRequiring energy42
3692189947ExergonicReleasing energy43
3692189948Standard Free-Energy Change (ΔG°)A constant that is characteristic of each specific reaction. Also, the initial concentrations of reactants and products.44
3692189949Equation for calculating free-energy changeΔG° = -RT ln Keq45
3692189950EnzymesBiocatalysts that greatly enhance the rate of specific chemical reactions without being consumed in the process.46
3692189951Transition StateA state of higher free energy than either reactant or product.47
3692189952Activation Energy (ΔG+)Difference in energy between the reactant in its ground state and in its transition state.48
3692189953CatabolismA pathway that degrades organic nutrients into simple end products in order to extract chemical energy and convert it into a form useful to the cell. E released by catabolism drives the synthesis of ATP.49
3692189954AnabolismA pathway that starts with small precursor molecules and converts them to progressively larger and more complex molecules (including proteins and nucleic acids).50
3692189955Feedback InhibitionIf a cell begins to produce more Protein A than it needs for protein synthesis, the unused Protein A accumulates and the increased concentration inhibits the catalytic activity of the first enzyme in the pathway, slowing the production of Protein A.51
3692189956Deoxyribonucleic Acid (DNA)The material that contains the information that determines inherited characteristics.52

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