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P&P Exam 1: Basic & Clinical Pharmacology Flashcards

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2134286614In the nervous system, what is the sensory input to provide information on internal and external environment?Afferent0
2134288128In the nervous system, what is the motor portion of the nervous system?Efferent1
2134300097What are the 3 components of the autonomic nervous system?Sympathetic, parasympathetic, and enteric2
2134303467The SNS is located where?Thoracolumbar3
2134304405The PSNS is located where?Craniosacral4
2134321450Where does the enteric nervous system receive input from?SNS, PSNS, and direct sensory input from wall of the gut5
2134369830What is the neurotransmitter for cholinergic receptors?AcH6
2134371305What is the neurotransmitter for adrenergic receptors?Epi, Dopamine, NE (primary), and co-transmitters (e.g. calcium - if a patient is not affected by increases in neurotransmitters the patient may be low on calcium)7
2134393566What is the primary neurotransmitter of adrenergic receptors?NE8
2134404205*Where are cholinergic fibers located?*- Pre-ganglionic efferent autonomic fibers - Somatic (non-autonomic) motor fibers to skeletal muscles - Most parasympathetic post-ganglionic fibers - Some sympathetic post-ganglionic fibers9
2134480302*Where are adrenergic receptors located?*- Post-ganglionic sympathetic fibers10
2134513834*What is the rate limiting step to Dopamine?*The formation of Tyrosine to Dopa11
2134522013What is given to stop formation of Tyrosine?Metyrosine12
2134526915Where does Reserpine stop formation of NE?Inhibits the vesicular monoamine transporter in the wall of the storage vesicle13
2134530193What 2 drugs inhibit NET (carries NE back into the cell cytoplasm from the synaptic cleft)?Cocaine and TCA drugs14
2134555132What is ergotrophic and what are some physiological effects?Ergotrophic is sympathetic. Physiologic effects are energy expenditure, fight or flight, cardiac stimulation, increased blood sugar, cutaneous vasoconstriction, and relaxes bronchial smooth muscle.15
2134558956What is tropotrophic and what are some physiological effects?Tropotrophic is parasympathetic. Physiologic effects are leading to growth, slowing of the heart, stimulation of digestive activity, and constricts bronchial smooth muscle (e.g. asthma patient will have cough early in the morning because SNS is non-existent)16
2134574984What is pre-synaptic regulation?- Can be inhibitory or excitatory - Negative feedback control17
2134681579What is an example of pre-synaptic regulation?Alpha 2 receptor on noradrenergic nerve terminals. Activated by NE and alpha 2 agonists. Activation DECREASES release of NE. G-protein mediated effect to inhibit calcium inward movement.18
2134693257What is post-synaptic regulation?- Modulation by history of activity Up-regulation: After denervation of tissues. Administration of drugs that deplete transmitter stores. E.g. Reserpine --> Increased sensitivity. BB --> Increased receptors. Withdrawal --> Increased beta activity. Down regulation - Modulation by other temporarily associated events19
2134877388What are the primary divisions of the ANS?SNS and PSNS20
2134878773What are the 2 main neurotransmitters in the ANS?AcH and NE21
2134880360What are type of receptors in the ANS?Cholinergic (AcH) and adrenergic (NE)22
2134883325What is meant by negative feedback?Pre-synaptic regulation - Can be inhibitory or excitatory23
2134896745What is the rate limiting step in the synthesis of catecholamines?Inhibited Tyrasine24

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