4305233609 | B6 absorption | -Requires dephosphorylation -Primarily in the jejunum | 0 | |
4305234487 | Passive diffusion of free forms | Physiological conditions | 1 | |
4305235160 | Phoshorylated forms are in excess | Absorbed without dephosphorylation | 2 | |
4305238242 | Muscle stores | 75-80% | 3 | |
4305241284 | Liver stores | 5-10% | 4 | |
4305242271 | Phosphorylation | Prevents the diffusion of the vitamin out of cells | 5 | |
4305243107 | Transamination | -Is the transfer of an amino group (-NH2) from one amino acid to an alpha-ketoacid -Important for the synthesis of non-essential amino acids | 6 | |
4305244967 | Binding to proteins | Prevent the dephosphorylation | 7 | |
4305246222 | Deamination | Is the removal of an amino group (-NH2) for example an amino acid and release as ammonia | 8 | |
4305246794 | Decarboxylation | -Is the removal of carboxy group (-COO-) from an amino acid or other molecule -For example synthesis of gamma-aminobutyric acid (GABA) from glutamate | 9 | |
4305247932 | Meat products | Adenosylcobalamin | 10 | |
4305247933 | Milk products | Methylcobalamin | 11 | |
4305248668 | Stomach | Pepsin and HCL release cobalamins from polypeptides | 12 | |
4305249605 | R proteins | -Found in saliva and gastric juices -Binds to vitamin and protects it from bacterial use | 13 | |
4305250149 | Intrinsic factor | Made and released in stomach but functions in intestine | 14 | |
4307560347 | B6 deficiency stages | 1. serum 2. cell concentrations diminish 3. biochemical deficiency occurs 4. Megaloblasic macrocytic anemia | 15 | |
4307560348 | Serum | Low levels of holotranscobalamin II | 16 | |
4307562551 | Biochemical deficiency | 1. decreased dna synthesis 2. elevated homocysteine in serum 3. elevated methylmalonic acid in serum | 17 | |
4307567053 | Megaloblasic macrocytic anemia | May be caused by pernicious anemia 1) autoimmune condition 2) antibodies attack parietal cells 3) decreased IF production | 18 | |
4307568877 | Severe B12 deficiency | a. Neurological symptoms b. Degeneration of spinal cord c. Presentation: absent reflexes, ataxia, no sense of touch d. results in: severe irreversible brain and nervous system damage, death | 19 |
Vitamin B6 and B12 Flashcards
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