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Kinetics Final Flashcards

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10656377144 examples of continuous input1) I.V. drip 2) I.V. infusion 3) Transdermal patch 4) Sustained release oral dosage forms0
1065637715What is the rate of infusion signified by?Ko1
1065637716What is the relationship between the amount of drug in the body and the rate of input and rate of clearance in continuous infusion?dA/dt = rate in - rate out rate in = input rate (amount/time); represented by Ko rate out = elimination rate constant x amount of drug in body = (Ke x A) dA/dt = Ko - KeA2
1065789403What is dA/dt at plateau of continuous infusion?aka at STEADY STATE dA/dt = 0 at max Cp (aka Cp,ss) rate in = rate out3
1065789404What is infusion rate (Ko) determined by at steady state?Clearance and Steady State Concentration: Ko = CL x Cp,ss4
1065789405Assuming 1-compartment model, when infused continuously at the same rate, all drugs with the same CLEARANCE will have the same _?_steady-state plasma concentration (Cp,ss)5
1065789406Assuming 1-compartment model, when infused continuously at the same rate, all drugs with the same HALF-LIFE will have the same _?_steady-state amount of drug in the body (A,ss)6
1065789407How long does it take to reach steady state in a continuous infusion?3.3 half lives to reach 90% of Cp,ss7
1065789408For continuous infusion at steady state, the term e^(-Ke*t) is equal to ?= 0.1 t½ = 0.693 / Ke → Ke = 0.693 / t½ t = 3.3(t½) →t½ cancels out, so gives e^(0.693*3.3) = 0.18
1065789409What happens to Cp,ss , A,ss , and Time to SS (steady state) when ↑ Ko?↑ Cp,ss ↑ A,ss no change in Time to SS9
1065789410What happens to Cp,ss , A,ss , and Time to SS when ↑ CL?↓ Cp,ss ↓ A,ss ↓ Time to SS10
1065789411What happens to Cp,ss , A,ss , and Time to SS (steady state) when ↑ V?no change in Cp,ss ↑ A,ss ↑ Time to SS11
1065789412What happens to Volume of Distribution if a displacement interaction takes place, i.e. something displaces drug bound to plasma proteins, as a result increasing the amount of free drug in the plasma?Increases Volume of Distribution12
1065834716What is the value of Cp,o when it is within ±10% of Cp,ss?Cp,o = 013
1065834717When Cp,o ≠ 0, the time to ±10% of Cp,ss is (the same? different?) as t₉₀%the time to ±10% of Cp,ss is DIFFERENT from the t₉₀%14
1095474408...1st row (↑K₀): ↑ ↑ → 2nd row (↑CL): ↓ ↓. ↓ 3rd row (↑V): → ↑ ↑15

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