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Biochemistry Chapter 10 Flashcards

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7870015534LipidsOrganic molecules that are characterized by low solubility in water, that is, are relatively hydrophobic0
7870020968Storage of energy-reduced compounds: lots of available energy -hydrophobic nature: good packing1
7870023394Insulation from environment-low thermal conductivity -high heat capacity (can "absorb" heat) -Mechanical protection (can absorb shocks)2
7870029159Water repellantHydrophobic nature: keeps surface of the organism dry -prevents excessive wetting (birds) -prevents loss of water via evaporation3
7870035285Buoyancy control and acoustics in marine mammals-increased density while diving deep helps sinking (just a hypothesis) -spermaceti organ may focus sound energy: sound stun gun?4
7870041502Membrane structuremain structure of cell membranes5
7870043507Cofactors for enzymes-vitamin K: blood clot formation -coenzyme Q: ATP synthesis in mitochondria6
7870047455Signaling moleculesParacrine hormones steroid hormones growth factors Vitamins A and D (hormone precursors)7
7870050396paracrine hormonesact locally8
7870052225steroid hormonesact body-wide9
7870054358Vitamins A and Dhormone precursors10
7870056906Pigmentscolor of tomatoes, carrots, pumpkins, some birds11
7870058569vitamin Eantioxidant pertaining of lipids12
7870067374Two major lipids-Lipids that contain fatty acids -Lipids that do not contain fatty acids13
7870069913Complex lipidscontain fatty acids14
7870071821Two complex lipidsstorage and membrane lipids15
7870074463Fatty acidscarboxylic acids with hydrocarbon chains containing between 4 to 36 carbons -Almost all natural fastty acids have an even number of carbons -most naturally fatty acids are unbranched16
7870079904Saturatedno double bonds between carbons in the chain17
7870081432Monounsaturatedone double bond between carbons in teh alkyl chain18
7870082774PolyunsaturatedMore than one double in the alkyl chain19
7870086387Systematic nameIUPAC nomenclature20
7870086388common namesuch as oleic acid21
7870088461Delta numberingDescribes location of the first carbon of the alkene in relationship to the carbonyl carbon22
7870096221Omega numberingDescribes location of the first carbon of the alkene in relationship to the terminal methyl23
7870128133Omega-3 fatty acids-essential nutrients -Humans need them but cannot synthesize them -They include ALA, DHA, and EPA --DHA, EPA can be synthesized from ALA24
7870134774Solubilitydecreases as the chain length increases25
7870135898Melting pointdecreases as the chain length decreases -Decreases as the number of double bonds increases26
7870141681Conformation of fatty acids-saturated chain adopt extended conformations -double bonds in natural unsaturated fatty acids are commonly in cis configuration, which kinks the chain27
7870145815cis conformationDouble bonds in fatty acids adopt ____ _________28
7870153878OrderlySaturated fatty acids pack in an _____ way -extensive favorable interactions29
7870156023disorderedUnsaturated cis fatty acids pack less orderly due to the kink -less-extensive favorable interactions30
7870163698lowerUnsaturated cis fatty acids have a ______ melting point than saturated fatty acids31
7870170010Trans fatty acids-form by partial dehydrogenation of unsaturated fatty acids -done to increase shelf life or stability at high temps of oils used in cooking -have extended conformation -higher melting points32
7870188614cardiovascular diseaseconsuming trans fats increases risk of _____________ _______33
7870196361FAfatty acids34
7870196362GLglycerolipids35
7870197576GPglycerophospholipids36
7870199223SPsphingolipids37
7870199224STsterol lipids38
7870200664PRprenol lipids39
7870200665SLSaccharolipids40
7870202849PKpolyketides41
7870207592Triacylglycerols(nonpolar) -majority of fatty acids in biological systems are found in this form -less dense than water42
7870210347fatssolid triacylglycerols43
7870211865oilsliquid triacylglycerols44
7870213281body fatprimary storage form of lipids using triacylglycerols45
7870218735esterificationTriacylglycerols are less soluble in water than fatty acids due to the ________ of the carboxylate group46
7870249802MoreFatty acids carry ____ energy per carbon than polysaccharides because they are produced47
7870253081LessFatty acids carry ____ water per gram because they are nonpoilar48
7870254931Glucose and glycogenfor short-term energy needs and quick delivery49
7870256969long-termFats are for ___ ____ energy needs, good storage, and slow delivery50
7870259977Waxesesters of long-chain saturated and unsaturated fatty acids with long-chain alcohols -insoluble and have high melting points51
7870270314Wax functions-Storage of metabolic fuel in plankton -protection and pliability for hair and skin in vertebrates -waterproofing of feathers in birds -protection from evaporation in tropical plants and ivy -used by people in lotions, ointments, and polishes52
7870282889BeeswaxMixture of a large number of lipids, including esters of triacontanol, and a long-chain alkane hentiacontane53
7870289212Membrane lipidscontain polar head groups and nonpolar tails (usually attached fatty acids)54
7870290975Membrane lipid diversification-modifying a different backbone -changing the fatty acids -modifying the head groups55
7870296997Organisms and tissuesDifferent __________ ___ _______ have different membrane lipid head group compositions56
7870304476Glycerophospholipids-primary constituents of cell membranes -two fatty acids form ester linkages witht eh first and second hydroxyl groups of L-glycerol-3-phosphate57
7870313544chargedphosphate group is ____ at physiological pH58
7870316734Structure of glycerophospholipdsUnsaturated fatty acids commonly found connected to C2 of glycerol-3-phosphate -the highly polar phosphate group may be further esterified by an alcohol; such substituent groups are called head groups59
7870324114glycerol-3-phosphateEsterification forms glycerophospholipids60
7870330604phosphatidycholine-choline as head group -major component of most eukaryotic cell membranes -many prokaryotes, including E. coli, cannot synthesize this lipid; their membranes do not contain it61
7870340117choline62
7870362816Plasmologen-vinyl ether analog of phosphatiylethanolamine -common in vertebrate heart tissue -also found in protozoa and anaerobic bacteria -function not well understood63
7870376211Platelets-Activating Factor-Aliphatic ether analog of phosphatidylcholine -Acetic acid has esterified position C2 -first signaling lipid to be identified -stimulates aggregation of blood platelets -plays role in mediation of inflammation64
7870384648Sphingolipids-Backbone: long-chain amino alcohol sphingosine -Fatty acid joined to sphingosine via an amide linkage, rather than an ester linkage as usually seen in lipids -polar head group is connected to sphingosine by a glycosidic of phosphodiester linkage -The sugar-containing glycosphingolipids are found largely in the outer face of plasma membranes65
7870406001sphingosinebackbone of sphingolipids -long-chain amino alcohol66
7870408093amide linkagefatty acid joined to sphingosine via:67
7870410056glycosidic or phosphodiesterPolar head group is connected to sphingosine by a ________ or ________ linkage68
7870414638Ceramidesphingosine + amide-linked fatty acid69
7870416325kSphingomyelinCeramide + phosphocholine attached to the alcoihol70
7870417918myelin sheathsphingomyelin is abundant in:71
7870421686Blood groupsdetermined in part by the type of sugars located on the head groups in glycosphingolipids72
7870426055glycosyltransferasesStructure of sugar determined by an expression of specific ________. This helps determine blood type73
7870429643O antigenindividuals with no active glycosyltransferase74
7870431451A blood groupIndividuals with a glycosyltransferase that transfers an N-acetylgalactosamine group75
7870434239B blood groupIndividuals with a glycosyltransferase that transfers a galactose group76
7870489894LysosomeStructural and signaling lipids are degraded in the ________77
7870507134Phospholipases A-Dphospholipids are degraded by: -each one cleaves a specific bond78
7870527290Gangliosidesdegraded via a series of enzymatic cleavages79
7870751303Lysosomal storage disorderscaused by the failure to correctly degrade gangliosides results in build-up of lipids in lysosomes, a dysfunction categorized as:80
7870756318Sterol-Steroid nucleus: four fused rings -hydroxyl group (polar head) in the A-ring -Various nonpolar side chains -tetracycle structure is almost planar81
7870797725Cholesterol-this and related sterols are present in membranes of most eukaryotic cells --modulate fluidity and permeability --thicken the plasma membrane --no sterols in most bacteria82
7870801737Mammalsobtain cholesterol from food or synthesize it de novo in the liver83
7870811642Cholesterol bound to proteins-transported to tissues via blood vessels -cholesterol in low-density lipoproteins tends to deposit and clog arteries84
7870823651hormonesmany are derivatives of sterols85
7870826718Steroids-oxidized derivatives of sterols -have the sterol nucleus but lack the alkyl chain found in cholesterol -more polar than cholesterol86
7870831017gonads and adrenal glandslocation of the synthesis from cholesterol87
7870903386carrier proteinsaid in the transport of steroid hormones in blood stream88
7870906087male and female sex hormonesmany steroid hormones are what kind of hormones89
7870909167testosterone90
7870909958cortisol91
7870910913prednisone92
7870915907β-Estradiol93
7870918268Aldosterone94
7870919649Prednisolone95
7870921362Brassinolide96
7870924801Biologically active lipids-present in much smaller amounts than storage or structural lipids -play vital roles as signaling molecules between nearby cells97
7870928814Lipid soluble vitaminsVitamins A, D, E, and K98
7870932938Arachidonic acid derivatives-act as signaling lilpids -enzymatic oxidation99
7870936578Prostaglandinsinflammation and fever100
7870938108thromboxanesformation of blood clots101
7870938110leukotrienessmooth muscle contraction in lungs102
7870940345Retinolvitamin A, derived from beta carotene -involved in visual pigment -precursor for other hormones involved in signaling103
7870947920Vitamin Ean antioxidant104
7870947922Vitamin Ka blood clotting cofactor (phylloquinone)105
7870950306Warfarina blood anticoagulant106
7870951718Ubiquinonea mitochondrial electron carrier (coenzyme Q)107
7870953673Plastoquinonea chloroplast electron carrier108
7870955619Dolichola sugar carrier109
7870959125Polyketidesbiologically active lipids with medicinal uses: -diverse family of compounds synthesized similarly to fatty acid biosynthesis --commonly secondary metabolites with specialized function110

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