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Medical genetics

AP Bio_pedigree_analysis_and_genetic_diseases

Subject: 
Biology
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Genetics
Biology
Classical genetics
RTT
Medical genetics
Dominance
Sickle cell trait
Population genetics
Sickle cell disease
Genetic disorder
Lethal allele
Mendelian inheritance

Pedigree Analysis * A pedigree is a family tree that describes the interrelationships of parents and children across generations * Inheritance patterns of particular traits can be traced and described using pedigrees * Pedigrees can also be used to make predictions about future offspring * We can use the multiplication and addition rules to predict the probability of specific phenotypes Recessively Inherited Disorders * Many genetic disorders are inherited in a recessive manner * These range from relatively mild to life-threatening The Behavior of Recessive Alleles * Recessively inherited disorders show up only in individuals homozygous for the allele * Carriers are heterozygous individuals who carry the recessive allele but are phenotypically normal
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