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Presynaptic (must be a motor neuron) 1 - Nature of impulse +++ --- 1 - Increase of permeability of Ca 2+ 1 - Movement of vesicles 1 - Fusion of vesicles with membrane 1 - Transmitter release 1 - Acetylcholine 1 - Diffusion of transmitter (20 nm) 1 - Cholinesterase 1 - Motor end plate or terminal bouton Postsynaptic (muscle be a muscle fiber) A. Transmitter Effects 1 - Specific receptor sites 1 - Causes depolarization/action potential 1 - Action potential sweeps fiber membrane/T. tubules 1 - Release of Ca 2+ from Sarcoplasmic reticulum (T. cisternae) B. Calcium Effects 1 - Calcium floods sarcomere 1 - Calcium binds to troponin 1 - Bound troponin displaces tropomyosin 1 - Calcium returned by active transport (Ca2+ pump) C. Actinomyosin Complex

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