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Hormones

hormone - regulatory chemical secreted by endocrine gland 

  • only target cell can respond to hormone (but blood carries hormone throughout the body)
  • neurotransmitter - only diffuse a short distance, but may be chemically similar to hormones
    • effects the postsynaptic neuron
    • neurohormone - chemicals secreted from neurons into blood
    • some molecules work as both neurotransmitters and hormones
  • targets ligand-gated receptors on target cells
    • messages sometimes relayed through 2nd messenger, magnified through enzyme cascade
  • paracrine regulation - using chemicals as local regulators in an organ
  • pheromone - chemical released into the environment
    • used as communication between animals

types of hormones

  • polypeptides - chains of amino acids (never more than 100)
    • insulin, ADH
  • glycoproteins - polypeptides (w/ over 100 amino acids) attached to carbohydrate
    • FSH, LH
  • amines - derived from tyrosine/tryptophan amino acids
    • catecholamines - secreted by adrenal medulla, includes adrenaline/noradrenaline
    • melatonin, thyroid hormone
  • steroids - lipids derived form cholesterol
    • sex steroids - secreted by testes, ovaries, placenta, adrenal cortex
    • corticosteroids - secreted only by adrenal gland
  • lilophilic hormones - fat soluble, includes steroids/thyroxine
  • lilophobic hormones - water soluble, all other hormones
  • most releases of hormones controlled by the brain

hormones that enter cells - lipophilic hormones easily enter cells (can pass plasma membrane) 

  • either finds receptor in cytoplasm or inside nucleus (either way, eventually reaches nucleus)
  • hormone response elements - DNA segments binding to hormones

hormones that do not enter cells - lipophobic hormones can’t pass plasma membrane 

  • have to bind to receptors
  • 2nd messenger needed within the cell to get the reactions started
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