hormone - regulatory chemical secreted by endocrine gland
- only target cell can respond to hormone (but blood carries hormone throughout the body)
- neurotransmitter - only diffuse a short distance, but may be chemically similar to hormones
- effects the postsynaptic neuron
- neurohormone - chemicals secreted from neurons into blood
- some molecules work as both neurotransmitters and hormones
- targets ligand-gated receptors on target cells
- messages sometimes relayed through 2nd messenger, magnified through enzyme cascade
- paracrine regulation - using chemicals as local regulators in an organ
- pheromone - chemical released into the environment
- used as communication between animals
types of hormones -
- polypeptides - chains of amino acids (never more than 100)
- insulin, ADH
- glycoproteins - polypeptides (w/ over 100 amino acids) attached to carbohydrate
- FSH, LH
- amines - derived from tyrosine/tryptophan amino acids
- catecholamines - secreted by adrenal medulla, includes adrenaline/noradrenaline
- melatonin, thyroid hormone
- steroids - lipids derived form cholesterol
- sex steroids - secreted by testes, ovaries, placenta, adrenal cortex
- corticosteroids - secreted only by adrenal gland
- lilophilic hormones - fat soluble, includes steroids/thyroxine
- lilophobic hormones - water soluble, all other hormones
- most releases of hormones controlled by the brain
hormones that enter cells - lipophilic hormones easily enter cells (can pass plasma membrane)
- either finds receptor in cytoplasm or inside nucleus (either way, eventually reaches nucleus)
- hormone response elements - DNA segments binding to hormones
hormones that do not enter cells - lipophobic hormones can’t pass plasma membrane
- have to bind to receptors
- 2nd messenger needed within the cell to get the reactions started