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13850679672law of dominancewhen 2 organisms homozygous for different traits are crossed to produce hybrids. only exhibit dominant trait0
13850679673law of segregationduring formation fo gametes, 2 traits carried by each parent separates1
13850679674monohybrid crosscross between organisms hat are each hybrid for one trait2
13850679675testcross/backcrossdetermines genotype of an organism showing only the dominant trait3
13850679676law of independent assortmentcross between 2 individuals hybrid for 2 or more different traits (Tt x Yy)4
13850679677incomplete dominanceblending (black animal & white animal produce gray animal)5
13850679678codominanceboth traits show. there are 2 allelic variants at a single gene locus.6
13850679679multiple allelswhen there are more than 2 allelic forms of a gene. ex: human blood types A, B, AB, O7
13850679680pleiotropyability of a single gene to affect an organism in several ways ex: cystic fibrosis causes thick mucus that causes pleiotropic effects like poor absorption of nutrients and bronchitis8
13850679681epistasis2 separate genes control one trait, but one gene masks the expression of the other. the gene that masks the expression of the other gene is epistatic ex: agouti coat color only occurs with A and B. Without B, A is albino9
13850679682polygenic inheritanceblending of several separate genes that vary along a continuum. ex: two parents who are short can produce child that is tall10
13850679683genomic imprintingVariation in phenotype depending on whether an allele of from the male or female parent.11
13850679684extranuclear genesGenes outside the nucleus, in the mitochondria and chloroplasts. ex: defects in mitochondrial genes can cause weakness in muscles12
13850679685multifactorial basisa genetic component plus a significant environmental influence13
13850679686penetranceThe percentage of individuals with a particular genotype that actually displays the phenotype associated with the genotype. ex: breast cancer gene14
13850679687linked genesgenes on the same chromosome. ex: humans have 46 chromosomes in every cell and therefore have 46 linkage groups. linked genes tend to be inherited together unless separated by crossover15
13850679688autosomesAny chromosome that is not a sex chromosome. 44 of 46 chromosomes are autosomes16
13850679689sex-linked traittraits carried on x chromosome17
13850679690recessive sex-linked traitscolor blindness and hemophilia18
13850679691The farther apart 2 genes are located on a chromosome, themore likely they will be separated during meiosis because of crossover19
13850679692site of crossoverchiasma20
13850679693somatic cellbody cell21
13850679694genetic mosaicsome cells have one X inactivated, other cells have other X inactiavted.22
13850679695Barr bodyA dense body formed from a deactivated X chromosome.23
13850679747all females have one Barr body. males do not24
13850679696gene mutationcaused by change in DNA sequence25
13850679697chromosome mutationcan be observed under microscope26
13850679698karyotypeProcedure that analyzes the size, shape, and number of chromosomes27
13850679699chromosomal abberationsdeletion inversion (chromosomal fragment reattaches in reverse orientation) translocation (chromosome fragment attaches to nonhomologous chromosome) polyploidy (extra sets of chromosomes)28
13850679700nondisjunctionchromosomes fail to separate during meiosis29
13850679701theory of endosymbiosisEukaryotic cells emerged when mitochondria and chloroplasts, once free-living prokaryotes, took up permanent residence inside other larger cells, about 1.5 billion years ago.30
13850679702prokaryotes don't havenuclei or internal membranes31
13850679703function dictatesform32
13850679704nucleolusplace where rRNA is produced33
13850679705ribosomesprotein factories. found in cytoplasm or ER34
13850679706peroxisomescontain catalase, which converts hydrogen peroxide into water35
13850679707endomembrane systemconsists of Golgi apparatus, lysosomes, vesicles, vacuoles, and plasma membrane. regulates protein traffic and performs metabolic functions36
13850679708nucleuschromosomes wrapped with proteins37
13850679709rough ERstudded with ribosomes. produces proteins38
13850679710smooth ER1. production of steroid hormones 2.stores Ca2+ ions 3. detoxifies drugs39
13850679711lysosomesdigest with hydrolytic enzymes40
13850679712mitochondriasite of cellular respiration. have their own DNA41
13850679713vacul=olesstorage. freshwater protists have contractive vac to pump out water42
13850679714chloroplasthave inner membrane system called thylakoids43
13850679715cytoskeleton1. microtubules make up cilia, flagella, spindle fibers. spindle fibers separate chromosomes 2. microfilaments made from actin filaments44
13850679716centrioles, centrosomes, MTOCSorganize spindle fibers45
13850679717plasma membranefluid mosaic model consists of phospholipid bilayer46
13850679718ligandmolecule that binds to a receptor47
13850679719sodium-potassium pumppumps Na+ and K+ ions across a nerve cell48
13850679720bulk flowmovement of a fluid in a direction in an organism ex: blood moves my blood pressure and sap goes from source to sink49
13850679721gap junctionsallow materials to pass from cytoplasm of a cell to another. in plants - plasmodesmata50
138506797223 stages of cell signaling1. reception (ligand binds) 2. transduction (signal converted to a form that bring a response) 3. specific cellular response occurs51
13850679723second messengerssend messages inside signal after reception. ex: cAMP52
138506797243 types of cell surface receptorsion channel receptors, G-protein coupled receptors, and protein kinase receptors53
13850679725GPCRs are on whenit bonds to GTP, which activates adenylyl cyclase that catalyzes the conversion of ATP to cAMP54
13850679726RTKsmembrane receptors that attach phosphates to tyrosines. can trigger multiple pathways at once55
13850679727protein kinasesactivate proteins56
13850679728protein phosphatasesinactivate proteins by removing phosphate groups57
13850679729apoptosisprogrammed cell death58
13850679730apoptosis is carried out whenembryonic development, genetic damage that could lead to cancer, and plant defense against fungus59
13850679731molecules that can travel across plasma membranenonpolar substances. large polar molecules must travel through protein channel60
138506797325 special traits of water1. high specific heat 2. high heat of vaporization 3. universal solvent 4.strong cohesion-tension (capillary action, transpiration-pull cohesion tension) 5. ice is less dense than water (insulates water)61
13850679733structural isomersame # atoms, different arrangement62
13850679734cis-trans isomersdiffer in arrangement about a double bond63
13850679735enatiomersmirror images64
13850679736pHH+ concentration increases, pH decreases65
13850679737carbohydratesCHO fuel and building material monosaccharides, glucose, galactose, fructose can be joined by dehydration synthesis or condensation66
13850679738lipidsfats, oils, waxes, steroids -most lipids consist of 1 glycerol and 3 fatty acids -cell membranes are made of phospholipids -saturated or unsaturated -energy storage, structural, endocrine67
13850679739proteins-CHONSP -polymers consisting of units called amino acids bound by peptide bonds -amino acids are made of carboxyl group, amine group, and variable R68
13850679740primary structureunique linear sequence of amino acids69
13850679741secondary structurehydrogen bonding within polypeptide molecule. can be alpha helix or beta pleated sheet70
13850679742tertiary structure3D shape protein. caused by bonding betwen R groups or disulfide bonds between cysteine amino acids71
13850679743quaternary structureproteins that consist of more than one polypeptide chain72
13850679744denaturationIn proteins, a process in which a protein unravels and loses its native conformation, thereby becoming biologically inactive.73
13850679745chaperoninsassist in folding of proteins74
13850679746techniques to reveal 3D shape of proteinsX-ray crystallography, NMR spectroscopy, bioinformatics75
13850679748functional groups76
13850688899first law of thermodynamicsEnergy cannot be created or destroyed77
13850688908second law of thermodynamicswhen energy is changed from one form to another, some useful energy is always degraded into lower quality energy (usually heat)78
13850690784induced fit modelsubstrate binding to an active site improves the fit between the two79
13850692043enzymes often require assistance fromcofactors (inorganic) or coenzymes80
13850694286competitive inhibitionsubstance that resembles the normal substrate competes with the substrate for the active site81
13850715823noncompetitive inhibition aka allosteric regulatorsbind to a site separate from active site of enzyme, which changes the enzyme into a shape that prevents enzyme from catalyzing substrate into product82
13850729438feedback inhibitionend product of pathway is allosteric inhibitor83
13850730229cooperativitybinding of one substrate molecule can stimulate binding or activity at other active sites84
13850737828anaerobic respirationglycolysis + alcoholic fermentation/lactic acid fermentation85
13850741121aerobic respirationglycolysis + Krebs + electron transport chain + oxidative phosphorylation86
13850748460glycolysistakes 1 molecule of glucose --> 2 three carbon molecules of pyruvate. also produces ATP by substrate level phosphorylation. PFK is allosteric enzyme for glycolysis87
13850781951citric acid cycleactivated by acetyl coA (pyruvate with coenzyme A). Generates ATP per turn by substrate-level phosphorylation. Remainder of energy reduces NAD and FAD to shuttle electrons to e transport chain. Each turn of Krebs cycle makes 3 NADH, 1 ATP, 1 FADH88
13851062759electron transport chaincarries electrons delivered by NADH & FADH to oxygen. ETC consists of cytochromes.89
13851089673oxidative phosphorylationATP is produced through oxidative phosphorylation (chemiosmosis uses potential energy from proton gradient to phosphorylate ADP and produce ATP). produces the most ATP90
13851091694substrate-level phosphorylationoccurs when enzyme kinase transfers phosphate to ADP. produces small amount of ATP during glycolysis & Krebs91
13851094815alcoholic fermentationanaerobic process in which cells convert pyruvic acid into carbon dioxide and ethyl alcohol; carried out by many bacteria and fungi such as yeasts92
13851096365lactic acid fermentationThe conversion of pyruvate to lactate with no release of carbon dioxide.93
13851100306cholorophyll aabsorbs blue-violet and red light. participates directly in light reactions of photosynthesis94
13851102869what are the steps of non-cyclic photophosphorylation?1. PII 2. photolysis: splitting of water for electrons and O2 as waste product 3. ETC: electron flow provides energy for ATP by chemiosmosis. 4. chemiosmosis: ATP formed during light reactions of photosynthesis (proton gradient). 4. NADP: reduced when it picks up 2 protons 5. PI95
13851115960sole purpose of cyclic photophosphorylation?ATP production96
13851122057what are 2 possible routes for light-dependent reactions?noncyclic flow or cyclic photophosphorylation97
13851124659what is the main process of light-independent reactions?Calvin cycle98
13851125848what is the process that occurs in the Calvin cycle?carbon fixation. Co2 enters cycle and attaches to 5-carbon sugar to become 6-carbon. The 6-carbon breaks down into two 3-carbon phosphoglycerate.99
13851128290what does calvin cycle use to run?products of light reactions, ATP and NADH100
13851140670what are strategies to minimize water loss in plants?photorespiration and C4 photosynthesis101
13851159243how is DNA structured?helix. strands are antiparallel102
13851161564DNA is ____ conservativesemi103
13851162661where does DNA replication begin?origin of replication104
13851163227DNA replication occursin both directions105
13851165208DNA polymerase catalyzes elongation byadding nucleotides to the growing chain from 5' to 3'106
13851165870the leading strand runs5' to 3'107
13851166274the lagging strand runs3' to 5'108
13851167603the lagging strand is synthesized in pieces calledOkazaki fragments, which are then sealed by DNA ligase109
13851169635DNA pol IIIadds nucleotides110
13851170428DNA pol Iremoves the RNA primer and replaces it with DNA111
13851180287what are the steps to go from gene --> protein?transcription (DNA -> RNA) to translation (RNA -> protein)112
13851185325what does transcription produce?mRNA aka template strand113
13851188274what does translation do?converts an mRNA message into a polypeptide or protein114
13858403850mRNA base triplets are calledcodons115
13858410787RNA polymerase separates the 2 DNA strands andconnects RNA nucleotides as they base-pair along the template strand116
13858453921the DNA sequence that RNA polymerase attaches to is calledthe promoter117
138584723833 stages of transcriptioninitiation, elongation, termination118
13858500748transcription initiation complex is made oftranscription factors + RNA pol II119
13858512587what are 2 post-transcriptional modifications to RNA?5' cap and poly-A tail120
13858526861snRNA is involved in ______.excision of introns and joining of exons121
13858542719tRNA functions in transferring amino acids from cytoplasm to ____a ribosome122
13858578700what are on the ends of tRNA?amino acid, anticodon123
13858603506a ribosome is composed ofrRNA and protein124
13858609833What are the 3 binding sites for tRNA?A, P, E125
13858765151what are 2 types of point mutations?Base pair substitutions & Base pair insertions or deletions126
13859104357operonsinducible or repressible clusters of genes transcribed as a single mRNA127
138591097863 parts of operonoperator, promoter, genes of the operon128
13859149143regulatory genes produce ______repressor proteins that may bind to operator site and block RNA pol, turning the operon off129
13859159274a repressible operon is typicallyon. anabolic130
13859159275a inducible operon is typicallyoff. catabolic131
13859175640DNA methylation causes DNA to become _____tightly packed, reducing gene expression132
13859187027histone acetylation causes chromatin to become _____less packed, encouraging transcription133
13859204825epigenetic inheritanceinheritance of traits transmitted by mechanisms that do not involve the nucleotide sequence (DNA expression is different)134
13859240490what 2 types of RNA can block gene expression?micro RNA & interfering RNAs135
13859298529what 3 processes lead to different cell types in an organism?cell division, cell differentiation, morphogenesis136
13859310179oncogenes arecancer causing genes137
13859315246proto-oncogenes become oncogenes whena mutation occurs that increases production138
13859322687what is an important tumor-suppressing gene?p53139
13859543828operatora sequence of nucleotides near the start of an operon to which an active repressor can attach140
13859548314RNA polymeraseEnzyme similar to DNA polymerase that binds to DNA and separates the DNA strands during transcription141
13859654760transcription factorshelp RNA polymerase bind to promoter142
13859757168primer are to DNA as promoter is toRNA143
13859798201lac operon is an example ofan inducible operon (typically off, catabolic). the presence of lactose turns it on144
13859842151trp operon is an example ofa repressible operon (typically on, anabolic)145
13859932070prions are pathogens thatare misfolded, infectious proteins that cause the misfoldings of normal proteins in brain cells of various species146
13859940660an example of a prion diseasemad cow disease147
13859961125recombinant DNA isartificial DNA, a combo of 2 organisms ex: human DNA & E. coli148
13859966959plasmidA small, circular section of extra DNA149
13859982516restriction enzymes cancut DNA at specific nucleotides150
13864660317restriction enzymes are used ingenetic engineering151
13864751187DNA ligaseenzyme that chemically links DNA fragments together152
13864837605steps of gene cloning1. identify and isolate gene of interest and cloning vector 2. cut the gene of interest and vector w/ same restriction enzyme (giving plasmid and human gene same sticky ends) 3. join the two pieces of DNA 4. get the vector carrying the gene of interest into a host cell, (the plasmids are taken up by the bacterium by transformation) 5.select for cells that have been transformed153
13864884511nucleic acid hybridizationthe base pairing of one strand of a nucleic acid to a complementary sequence on another strand. used to identify genes of interest154
13864894457PCR (polymerase chain reaction)is used to copy and amplify minute quantities of DNA155
13864899255gel electrophoresisThe separation of nucleic acids or proteins, on the basis of their size and electrical charge, by measuring their rate of movement through an electrical field in a gel.156
13865148178restriction fragment length polymorphism (RFLP)small differences in DNA sequences that act as DNA fingerprints. used in rape and paternity tests157
13865836157DNA microarray assayscompare patterns of gene expression in different tissues, at different times, or under different conditions158
13865842651homeotic genesGenes that determine basic features of where a body part is.159
13866015285Griffith provedtransformation in bacteria160
13866017972Meselson and Stahl provedthat DNA replicates in a semiconservative fashion161
13866019765Hershey and Chased discoverednuclear material in the bacteriophage, not the protein coat, infects a bacterium.162
13866024773Rosalind FranklinUsed X-ray diffraction to discover the double-helical structure of DNA.163
13893295831G0 phaseA nondividing state in which a cell has left the cell cycle.164
13893300152G1 checkpoint"restriction point", if a cell receives a go-ahead signal at the checkpoint, it will complete the G1,S,G2, and M phases and divide, if it does not receive a go-ahead signal at that point, it will exit the cycle, switching into the G0 phase165
13893381436CO2 is carried in theplasma166
13893387322what is the blood buffer system called?carbonic acid-bicarbonate ion system167
13893427034base and acid of blood buffer system?carbonic acid lowers pH bicarbonate highers it168
13893488927atriathe two upper chambers of the heart, receive blood169
13893493161ventriclesthe two lower chambers of the heart, and they pump blood out to the lungs and body.170
13893509411examples of temperature regulationshivering, migration171
13893524317ectothermsanimals that are not able to control their body temperature172
13893528945endothermswarm blooded, use metabolic processes to produce body heat173
13893558278north-south clineAnatomical difference across a geographic range (small ear rabbits vs large ear rabbits)174
13893576008osmoregulationregulation of solute concentrations and water balance by a cell or organism175
138935842983 types of nitrogenous wasteurea, uric acid, ammonia176
13893664528filtration is kidneys ispassive and non-selective177
13893677791secretion in kidneys isactive and highly selective. uptake of contaminants not filtered into Bowman's capsule178
13893690086reabsorption in kidneys ispassive, active, and selective. movement of solutes from filtrate to blood179
13893735801nephronFunctional unit of the kidney, consisting of a glomerulus, renal tubule, and collecting tubule.180
13894847297aldosteroneHormone that stimulates the kidney to retain sodium ions and water. in response to decrease in blood pressur eor volume181
13894853682ADHreleased in response to dehydration due to excessive sweating or inadequate water intake182
13894869179reninhormone secreted by the kidney that raises blood pressure183
13895013057positive feedbackFeedback that tends to magnify a process or increase its output.184
13895013058negative feedbacka mechanism of response in which a stimulus initiates reactions that reduce the stimulus (hen there is enough of thyroxin, the hypothalamus stops stimulating the pituitary)185
13897086144eyeballs are an example of signal transduction pathway-photons pass through lens -absorbed by photoreceptors -signal transduction pathway -G protein signaling mechanism triggered -186
13906587410what is the passage of a nerve impulse?receptor -> sensory neuron -> interneuron -> motor neuron -> effector187
13906597323effectorgland/muscle188
13906625700membrane potentialdifference in electrical charge between cytoplasm (-) and extracellular fluid (+)189
13906632157polarized state (resting potential)unstimulated. -70mV190
13906633925the sodium potassium pumpmaintains polarization191
13906636780a stimulus must be strong enough to overcomethe resting threshold, or resting potential192
13906672256if a stimulus triggers a sodium ion-gated channel, sodium flows into the cell and this results inin decrease in polarization193
13906678329if a stimulus triggers a potassium ion-gated channel, potassium flows into the cell and this results inmembrane potential increases, membrane becomes hyperpolarized194
13906686450esteraseAn enzyme that breaks down excess neurotransmitter195
13906917113example of cell signalingactivation of helper T cells that activate cytotoxic Tc cells196
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