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B12 Flashcards

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6072543137Co enzymeCH3 (Mehylcobalamin)0
6072544670Food sourcesMeats1
6072545591DRIFemales & Males: 2.4 ug2
6072547322Digestion (1-5 steps)1. Cleavage of B12 from proteins in stomach (by pepsin & HCl) 2. B12 binds to R protein in stomach 3. B12 is cleaved from R protein in intestine 4. B12 binds to intrinsic factor in intestine 5. B12 complex is absorbed in ileum3
6072550356Problems with absorption• Sometimes B12 not released from • R protein (low enzyme levels) • IF (intestinal acidity too high) • Absorption of B12: 11 - 65%4
6072552361FunctionConversion of homocysteine to methionine5
6072554360Deficiency1.Megalobastic macrocytic anemia 2. Neuropathy (memory loss, dementia) 3. Heart Disease6
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