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B12 Tough Pharm Drugs Flashcards

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5598641395AnastrazoleSelective aromatase inhibitor (reversible) Tx: PM hormone dependent B Cx0
5598652711ExemestaneIrreversible aromatase inhibitor Tx: PM hormone dependent B Cx1
5599896132NorethindroneProgestin only Mini-pill -- 99.0% effective "thin" = no baby2
5599901921NorgestrelProgestin only Mini-pill -- 99.0% effective don't "gest" about being pregnant (don't confuse w/ norgESTIMATE)3
5600000551Ethinyl estradiolEstogen portion of COC "thin" = no baby4
5600000553MestranolEstrogen portion of COC5
5600124318NorgestimateProgestin only No Estrogen effects "estimate" 0 Estrogen effects6
5600185985MifepristoneCompetitive inhibitor of progesterone receptor *Abortion pill* through day 49 "muff" the baby like the 49'ers muff punts7
5631017832AminoglutethimimdeCorticosteroid inhibitor MOA: Inhibits p450 scc Tx: Cushing disease8
5631024977KetoconazoleMOA: Inhibits C17-20 lyase Tx: Cushing's, Hirsutism inhibits gonadal and adrenal steroid synthesis... Corticosteroid inhibitor and anti-androgen9
5631043356SpironolactoneCorticosteroid inhibitor MOA: antag aldosterone synthesis and testosterone synthesis <-- reduces [C17-20 lyase] Tx: Hirsuitism, HTN Corticosteroid inhibitor and anti-androgen SE: hyperkalemia, gynocomastia10
5631072815EplerenoneCorticosteroid inhibitor Tx: anti-HTN, heart failure MOA: Aldosterone antag *No gynocomastia*11
563118691517B-hydroxysteroid dehydrogenaseandrostenedione --> testosterone12
56311948105 alpha reductaseTestosterone --> DHT13
5631223046AbirateroneAntiandrogen Tx: metastatic castration resistant prostate cancer MOA: inhibits CYP17 SE: hepatotoxic14
5631232569*Flutamide*Antiandrogen Tx: prostate cancer MOA: competitive inhibitor of DHT binding to androgen receptor SE: hepatitis, anemia15
5631247919*Finasteride*Antiandrogen Tx: BPH, bladness MOA: 5 alpha reductase inhibitor finAsteRIde...Alpha Reductase Inhibitor16
5631285387PDE5cleaves cGMP --> erection "afils" are PDE5 inhibitors cGMP --> smooth muscle relaxation17
5634088668CincaletPTH drug MOA: Calcimimetic, lowers PTH by activating Ca++ sensing receptors in PT gland Tx: Hypercalcemia18
5634099248TeriparatideRecombinant PTH MOA: up serum Ca++, up osteoclast activity, decrease serum phosphate Low dose or intermittant = bone formation b/c PTh signals osteoblasts which then signal osteoclasts Tx: Osteoporosis19
5634118187Calcitriol Ergocalciferol, Cholecalciderol, DHT (dihydrotachysterol)Replaces Vit D, decrease PTH Tx: Rickets, Osteomalacia, SE: GI pain, kidney stones20
5634177883Calcitriol what form of Vit D?1, 25 OH Active21
5634182749Ergocalciferol what form of Vit D?D222
5634182750Cholecalciferol what form of Vit D?D323
5634185291Dihydrotachysterol what form of Vit D?Dihydrotachysterol shortest t1/224

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