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Biochemistry Flashcards

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14603698850amino acidsmolecules that contain an amino group and a carboxyl group0
14603698851amphotericcompound that contains both an acid and a base1
14603698852zwitteronhas both positive and negative charge, but the overall molecule is neutral2
14603698853peptidecomposed of amino acid subunits3
14603698854conjugated proteinsderive part of their function from covalently attached molecules4
14603698855enzymesimportant biological catalysts5
14603698856substratemolecule upon which an enzyme acts6
14603698857active sitelocation upon which an enzyme acts7
14603698858feedback regulationthe inhibition of an enzyme by its product8
14603698859feed-forward activationThe stimulation of an enzyme by an intermediate that precedes the enzyme in a metabolic pathway9
14603698860negative feedbackhelps maintain homeostasis10
14603698861competitive inhibitionoccupancy of the active site11
14603698862noncompetitive inhibitionbind to an allosteric site instead of the active site12
14603698863mixed inhibitionwhen an inhibitor can bind to either the enzyme or the enzyme-substrate complex, but has a different affinity for each13
14603698864uncompetitive inhibition-bind only to the enzyme-substrate complex, locking the substrate into the enzyme14
14603698865allosteric enzymesAlternate between an active and inactive form15
14603698866collagentrihelical fiber and makes up most of the extracellular matrix of connective tissue16
14603698867elastinimportant component of the extracellular matrix that has a primary role of stretching and recoiling17
14603698868keratinsintermediate filament proteins found in epithelial cells18
14603698869actinprotein that makes up microfilaments and thin filaments in myofibrils19
14603698870tubulinprotein that makes up microtubules20
14603698871myosinprimary motor protein that interacts with actin21
14603698872cell adhesion moleculesproteins found on the surface of most cells and aid in binding the cell to the extracellular matrix or other cells22
14603698873cadherinsA group of glycoproteins that mediate calcium-dependent cell-cell adhesion23
14603698874integrinshave to membrane-spanning chains, alpha and beta24
14603698875selectinsbind to carbohydrate molecules that projects from other cell surfaces25
14603698876Antibodies (immunoglobulins)proteins produced by beta-cells that function to neutralize targets in the body26
14603698877biosignalinga process in which cells receive and act on signals27
14603698878ion channelsproteins that create specific pathways for charged molecules28
14603698879facilitated diffusiona type of passive transport; the diffusion of molecules down a concentration gradient through a pore in the membrane; simple diffusion for molecules that are impermeable to the membrane29
14603698880ungated channelshave no gates and are therefore unregulated30
14603700442voltage gated channelsgate is regulated by the membrane potential change near the channel31
14603701987ligand gated channelthe binding of a specific substance or ligand to the channel causes it to open or close32
14603708648membrane spanning domainanchors receptors in cell membrane33
14603709415ligand binding domainstimulated by the appropriate ligand and induced a conformational change that activates the catalytic domain34
14603712100G-protein coupled receptorsa large family of integral membrane proteins involved in signal transduction35
14603712894electrophoresissubjects compounds to an electrical field, which moves them according to their net charge and size36
14603716245chromatographyuses physical and chemical properties to separate and identify compounds from complex mixtures37
14603719497edman degradationuses cleavage to sequence proteins of up to 50 to 70 amino acids38
14603721903stereoisomerscompounds that have the same chemical formula, but different spatial arrangement39
14603724966enantiomersstereoisomers that are nonidentical, nonsuperimposable mirror images of each other40
14603728858Haworth projectiondescribes the 3D conformation of cyclic structures41
14603729571aldonic acidsoxidized aldoses42
14603731772tautomerizationrearrangement of bond in a compound, usually by moving a hydrogen and forming a double bond43
14603737045polysaccharideslong chains of monosaccharides linked together by glycosidic bonds44
14603741948homopolysaccharidecomposed entirely of glucose45
14603743596heteropolysaccharidepolymer made up of more than one type of monosaccharide46
14603744980cellulosemain structural component of plants47
14603746458starchespolysaccharides that are more digestible by numbers48
14603749683glycogencarb storage unit in animals; branched polymer of glucose represents a storage form of glucose49
14603751226amphipathichas both hydrophilic and hydrophobic regions50
14603753815phospholipidsphosphate and alcohol polar heads, hydrophobic fatty acid tail held together by phosphodiester linkages; move rapidly in the plane of the membrane through simple diffusion51
14603757860glycerophospholipidsspecifically those phospholipids that contain a glycerol backbone bonded by ester linkages to two fatty acids52
14603761178sphingolipidshave a sphingosine backbone53
14603762825waxesesters of long chains of fatty acids with long chain alcohols54
14603764905terpenesclass of lipids built from isoprene moieties and share a common structural pattern with carbons grouped in multiples of five55
14603766607monoterpenessingle terpene, two isoprene56
14603767696sesquiterpenesthree isoprene units57
14603769456diterpenesfour isoprene units58
14603769931triterpenessix isoprene units59
14603771396tetraterpeneseight isoprene units60
14603772097steroidsmetabolic derivatives of terpenes and are very different from other lipids61
14603776252steroid hormonessecreted by endocrine glands into the bloodstream and then travel to protein carriers62
14603777804cholesterolmajor component of the phospholipid bilayer and is responsible for mediating membrane fluidity63
14603779901prostagladinsproduced by almost all cells in the body and are unsaturated carboxylic acids64
14603781784vitaminan essential nutrient that cannot be adequately synthesized by the body65
14603783184vitamin Aunsaturated hydrocarbon that is important in vision, growth, development, and immune function66
14603784525vitamin Dcan be consumed or found in a UV light-driven reaction in the skin67
14603786056vitamin Echaracterized by a substituted aromatic ring with a long isoprenoid side chain and are characterized as hydrophobic68
14603790171vitamin Kvital to the posttranslational modifications required to form prothrombin69
14617190559adipocytesstore large amounts of fat and are found primarily under the skin, around mammary glands, and in the abdominal cavity70
14617192183saponificationthe ester hydrolysis of triacylglycerols using a strong base71
14617193089surfactantlowers the surface tension at the surface of a liquid, serving as a detergent or emulsifier72
14617195238micellestiny aggregates of soap with hydrophobic tails turned inward and hydrophilic heads turned outward73
14617197268nucleosidescomposed of a five-carbon sugar bonded to a nitrogenous base74
14617197867nucleotidesformed when one or more phosphate groups are attached to c-5' of a nucleoside75
14617199466nucleoproteinsacid-soluble and tend to stimulate processes such as transcription76
14617200411heterochromatinappears dark under light microscopy and is transcriptionally silent77
14617201582euchromatindispersed chromatin78
14617202254replisome (replication complex)a set of specialized proteins that assist the DNA polymerases79
14617204073helicaseenzyme responsible for unwinding DNA, generating two single-stranded template strands ahead of polymerase80
14617204855supercoilinga wrapping of DNA on itself as its helical structure is pushed even further toward the telomers during replication81
14617206325metastasismigration to distant tissues by the bloodstream82
14617207146oncogenesmutated genes that cause cancer83
14617207635DNA cloninga technique that can produce large amounts of a desired sequence84
14617208070restriction enzymesenzymes that recognize specific double-stranded DNA sequences85
14617209199DNA librarieslarge collections of known DNA sequences86
14617209894genomic librariescontain large fragments of DNA and include both coding and noncoding regions of the genome87
14617210788hybridizationjoining of complementary base pair sequences88
14617211661polymerase chain reactionan automated process that can produce millions of DNA sequences without amplifying the DNA in bacteria89
14617213957southern blotused to detect the presence and quantity of various DNA strands in a sample90
14617215117transgenea disease-producing allele91
14617215645genea unit of DNA that encodes a specific protein or RNA molecule92
14617216305Messenger RNA (mRNA)carries the information specifying the amino acid sequence of the protein to the ribosome93
14617218646Transfer RNA (tRNA)responsible for converting the language of nucleic acids to the language of amino acids and peptides94
14617219525Ribosomal RNA (rRNA)synthesized in the nucleolus and functions as an integral part of the ribosomal machinery used during protein assembly95
14617222489point mutationif a mutation occurs and it affects one of the nucleotides in a codon96
14617224265missense mutationa mutation where one amino acid substitutes for another97
14617224911nonsense mutationA mutation where the codon now encodes for a premature stop codon98
14617227545frameshift mutationoccurs when some number of nucleotides are added to or deleted from the mRNA sequence99
14617228342transcriptionthe creation of mRNA from a DNA template100
14617229297intronsnoncoding sequences that stay in the nucleus101
14617229875exonsligate coding sequences that exit the nucleus as part of the mRNA102
14617231353translationprocess of converting the mRNA transcript into a functional protein103
14617231867phosphorylationaddition of a phosphate group by protein kinases to activate or deactivate proteins104
14617233734carboxylationaddition of carboxylic acid groups, usually to serve as calcium-binding sites105
14617235503glycosylationaddition of oligosaccharides as proteins pass through the ER and Golgi apparatus to determine cellular destination106
14617237289prenylationaddition of lipid groups to certain membrane-bound enzymes107
14617238221operona cluster of genes transcribed as a single mRNA108
14617238680Jacob-Monod modelused to describe the structure and function of operons109
14617240270structural genecodes for the protein of interest110
14617240663operator siteA nontranscribable region of DNA that is capable of binding a repressor protein111
14617241046promoter siteprovides a place for RNA polymerase to bind112
14617241899regulator genecodes for a protein knows as the repressor113
14617242267negative controlwhen the binding of a protein reduces transcriptional activity114
14617244629repressible systemsallow for constant production of a protein product115
14617245257transcription factorstranscription-activating proteins that search the DNA looking for specific DNA binding motifs116
14617246752DNA binding domainbinds a specific nucleotide sequence in the promoter region117
14617247738activation domainallows for the binding of several transcription factors and other important regulatory proteins118
14617249336enhancerallows for the control of one's gene expression by multiple signals119
14617250117cell membranea semipermeable phospholipid bilayer120
14617251326lipid raftscollections of similar lipids with or without associated proteins that serve as attachment points for other biomolecules121
14617259111flippasesassist in the transition or "flip" between layers122
14617259683gap junctionsallow for direct cell-cell communication and are often found in small bunches together123
14617260442tight junctionsprevent solutes from leaking into the space between cells via paracellular route124
14617261609desmosomesbind adjacent cells by anchoring to their cytoskeletons125
14617262331hemidesmosomesattach epithelial cells to underlying structures126
14617263479simple diffusionsubstances move down their concentration gradient directly across the membrane127
14617264556osmosiswater moves from a region of low solute concentration to one of higher solute concentration128
14617265331carriersonly open to one side of the cell membrane at any given point129
14617268308occluded statecarrier is not open to either side of the phospholipid bilayer130
14617268557channelsviable transporters for facilitated diffusion131
14617269297active transportresults in the net movement of a solute against its concentration gradient132
14617284087symportwhen both particles flow in the same direction across the membrane133
14617285550antiportwhen the particles flow in opposite directions134
14617286591endocytosisoccurs when the cell membrane invaginates and engulfs material to bring it into the cell135
14617287547pinocytosisthe endocytosis of fluids and dissolved particles136
14617288198phagocytosisingestion of large solids such as bacteria137
14617288646exocytosisoccurs when secretory vesicles fuse with the membrane, releasing material from inside the cell to the extracellular environment138
14617289826membrane potentialthe difference in electrical potential across cell membranes139
14617290417cristaenumerous infoldings which increase the available surface area for the integral proteins associated with the membrane140
14617291096GLUT 2a low difinity transporter in hepatocytes and pancreatic cells141
14617292342GLUT 4in adipose tissue and muscle and responds to glucose concentration in peripheral blood142
14617293226glycolysisa cytoplasmic pathway that converts glucose into two pyruvate molecules, releasing a modest amount of energy143
14617295991hexokinasewidely distributed in tissues and is inhibited by its product, glucose-6-phosphate144
14617297737glucokinasefound only in liver cells an pancreatic B-islet cells145
14617298746phosphofructokinase-1the rate-limiting enzyme and main control point in glycolysis146
14617299556phosphofructokinase-2converts a tiny amount of fructose-6-phosphate to fructose-2,6-biphosphate147
14617301832Glyceraldehyde-3-phosphate dehydrogenasecatalyzes an oxidation and addition of inorganic phosphate to its substrate148
146173026323-phosphoglycerate kinasetransfers the high energy phosphate from 1,3 biphosphoglycerate to ADP forming ATP and 3-phosphoglycerate149
14617306562pyruvate kinaseactivated by fructose 1,6-biphosphate from the PFK-1 reaction150
14617308528dihydroxyacetone phosphateused in hepatic acid and adipose tissue for triacylglycerol synthesis151
14617309145galactosethe disaccharide lactose present152
14617309523epimerasesenzymes that catalyze the conversion of one sugar epimer to another153
14617310420glycogenesissynthesis of glycogen granules154
14617312464glycogen synthasethe rate-limiting enzyme of glycogen synthesis and forms alpha-1,4-glycosidic bond found in the linear glucose chains of the granule155
14617315550branching enzymeresponsible for introducing alpha-1,6-linked branches into the granule as it grows156
14617319686glycogenolysisprocess of breaking down glycogen157
14617320691glycogen phosphorylasebreaks alpha 1,4 glycosidic bonds, releasing glucose 1 phosphate from the periphery of the granule158
14617321699debranching enzymea two-enzyme complex that deconstructs the branches in glycogen that have been exposed by glycogen phosphorylase159
14617328122isoformsslightly different versions of the same protein160
14617328485pyruvate carboxylasea mitochondrial enzyme that is activated by acetyl CoA161
14617329636Phosphoenolpyruvate carboxykinaseinduced by glucagon and cortisol, which act to raise blood sugar162
14617331015Fructose-1,6-bisphosphatasekey control point of gluconeogenesis and represents the rate-limiting step of the process163
14617332625glucose-6-phosphotasefound only in the lumen of the ER of liver cells164
14617333364NADPHacts as an electron donor in a number of biochemical reactions165
14617334885proton-motive forcean electrochemical proton gradient generated by the complexes of the electron transport chain166
14617336070complex 1transfer of electrons from NADPH to coenzyme Q167
14617339273complex 2receives electron from succinate168
14617339599complex 3facilitates the transfer of electron from coenzyme Q to cytochrome C169
14617340589Q cycletwo electrons are shuffled in from a molecule of upiquinone170
14617341305complex 4facilitates the culminating step of the electron transport chain171
14617342032chemiosmotic couplingallows the chemical energy of the gradient to be harnessed as a means of phosphorylating ADP172
14617343619conformational couplingsuggests that the relationship between the proton gradient and ATP synthesis is indirect173
14617345674hormone-sensitive lipasehydrolyzes triacylglycerols yielding fatty acids and glycerol174
14617346568lipoprotein lipasenecessary for the metabolism of chylomicrons and very low density proteins175
14617348005lipoproteinsaggregates of apolipoproteins and lipids176
14617348778chylomicronshighly soluble in both lymphatic fluid and blood and function in transport of dietary triacylglycerols, cholesterol, and cholesteryl esters to other tissues177
14617350765LDLdeliver cholesterol to tissues for biosynthesis178
14617351296HDLsynthesized in the liver and intestines and released as dense, protein rich particles in the blood179
14617353002apoproteinsform the protein component of lipoproteins180
14617353572citrate shuttlecarries mitochondrial acetyl-CoA into the cytoplasm181
14617354343nontemplate synthesislipid and carbohydrate synthesis182
14617354921proteolysisbreakdown of proteins183
14617355256urea cycleoccurs in the liver and is the body's primary way of moving excess nitrogen out of the body184
14617356139open systemsexchange both energy and matter with the environment185
14617357227closed systemsdo not exchange matter with the environment186
14617357946internal energythe sum of all of the different interactions between and within atoms187
14617358528bioenergeticsenergy states in biological systems188
14617358903homeostasisa physiological tendency toward a relatively stable state that is maintained and adjusted189
14617360022insulina peptide hormone secreted by the B-cells of the pancreatic islets of langerhans190
14617361842glucagona peptide hormone secreted by the alpha cells of the pancreatic islets of langerhans191
14617364130glucocorticoidsresponsible for part of the stress response192

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