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Chapter 18: Genomes and their Evolution Flashcards

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1471796721Genomicsstudy of whole sets of genes and their interactions0
1471796722Human genome projectsequencing of the human genome that began in 19901
1471796723Whole-genome shotgun approachstarts with the cloning and sequencing of DNA fragments from randomly cut DNA2
1471796724Sequencing by synthesisresulted in massive increases in speed and decreases in the cost of sequencing entire genomes3
1471796725Proteomicsstudy of the full protein sets (proteomes) encoded by gnomes4
1471796726Systems biologyaims to model the dynamic behavior of whole biological systems based on the study of the interactions among the system's parts5
1471796727Pseudogenesformer genes that have accumulated mutations over a long time and no longer produce functional protein6
1471796728Repetitive DNAconsists of sequences that are present in multiple copies in the genome7
1471796729Transposable elementsstretches of DNA that can move from one location to another within the genome8
1471796730Transpositiona transposable element moves from one site in a cell's DNA to a different target site by a type of recombination process9
1471796731Transposonstype of transposable element that can move within a genome by means of a DNA intermediate; move by a "cut and paste" mechanism, which removes the element from the original site; by a "copy and paste" mechanism, leaves a copy behind10
1471796732Retrotransposonsmove by means of an RNA intermediate that is a transcript of the retrotransposon DNA; always leave a copy at the original site during transposition, since they are initially transcribed into an RNA intermediate11
1471796733Simple sequence DNAcontains many copies of tandemly repeated short sequence12
1471796734Short tandem repeat (STR)when the unit contains 2-5 nucleotides13
1471796735Genetic profilea unique set of genetic markers that can be used to identify individuals14
1471796736Multigene familiescollections of two or more identical or very similar genes15
1471796737Domainsdiscrete structural and functions regions of proteins16
1471796738Single nucleotide polymorphins (SNPs)single base-pair sites where variation is found in at least 1% of the population17
1471796739Homeoboxspecifies a 60 amino acid homeodomain in the encoded proteins18

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