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Complement System Flashcards

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4839033447bothis the complement system useful for the innate or acquired immune system?0
4839036855anti-inflammatoryis the complement system cascade more pro-inflammatory or anti-inflammatory?1
4839037609liverwhere are the complement proteins synthesized?2
4839038591cleavagewhat activates the complement proteins?3
48390425392 different pieces 1. one binds to immune complex and becomes a functional part of it 2. the other floats away and becomes an inflammatory mediatorhow many pieces is a complement protein broken into and what do those pieces do?4
48390480301. Lysis via MAC 2. Opsonization 3. Activate inflammatory response 4. clearance of immune complexeswhat are the 4 important functions of the complement system?5
48390518761. Classical 2. Alternative 3. Lectinwhat are the three different complement system pathways of activation?6
4839052445classical pathwaywhat pathway is dependent on an antibody being present?7
4839053061classicalwhich pathway is initiated by the formation of an Ag-Ab complex?8
4839053889alternativewhich pathway is initiated by foreign cell surfaces?9
4839054999Lectinwhich pathway is initiated by host proteins binding to microbial surfaces?10
4839057490IgM and some classes of IgGwhich antibodies can initiate the classical pathway?11
4839059591C1what proteins make up the recognition unit?12
4839060394C4, C2, C3what proteins make up the activation unit?13
4839061428C5-C9what proteins make up the Membrane Attack Complex or MAC?14
48390633131. C1q 2. C1r 3. C1swhat subunits make up C1?15
4839064214collagen-like triple helixwhat structure does C1 make?16
48390733491. C1r 2. C1s 3. C1qLabel this structure17
4839078682C1q AND C1rwhat activates C1s?18
48390794946how many C1q are present in a C1 molecule?19
48390808784, 4how many C1r/C1s are present in a C1 molecule?20
4839083070C4 and C2first complement proteins cleaved by the recognition unit of the classical pathway21
4839083624C4b2awhat forms the activation unit of the classical pathway?22
4839084522C3what is considered the heart of the complement system?23
4839086257Activation unit or C4b2awhat cleaves C3?24
4839087249truet/f: C3a and, for the most part, all complement proteins with "a" are anaphylatoxins?25
4839090647C4b2awhat is C3 convertase?26
4839091824C4b2a3bwhat is C5 convertase?27
4839093347C5b6789what is the MAC?28
4839097482C3bwhat part of the C5 convertase binds C5?29
4839098174C4b2awhat part of the C5 convertase cleaves C5?30
4839099574C5bwhat complement protein initiates the formation of the membrane-attack complex?31
4839101153C9what forms the ring structure of the MAC?32
48391040891. C3 2. Factor B 3. Factor D 4. Properdinwhat are the four components of the alternative pathway?33
4839106252nothing. it hydrolyzes spontaneously.what hydrolyzes C3 to initiate the alternative pathway?34
4839113031stabilizes C3bBb in order to cleave C3 during the alternative pathwaywhat does properdin do?35
4839113765C3b of the alternative pathwaywhat protein does Factor B bind to?36
4839114217factor Dwhat cleaves Factor B?37
4839116940C3bBbthis is the alternative's version of C3 convertase38
4839120201it becomes C5 convertase which cleaves C5 which then generates C5b. C5b then initiates the formation of MACwhat happens when you add a C3b to C3bBb?39
4839122211Lectin pathwaythis pathway is the best for taking care of a bacterial invasion40
4839123382Lectin is a protein that binds to carbohydrateswhat is lectin and what does it bind to?41
4839125477mannose on bacterial cellswhat does mannose-binding lectin bind to?42
4839126345acute-phase inflammatory reactionswhat situation is MBL produced?43
4839128296alternative pathwaywhat pathway doesn't require a recognition unit?44
4839129586MASP-1 MASP-2 MASP-3the 3 serine proteases that act like C1 (lectin pathway)45
4839131111MBL binding to target cellwhat is required for the serine proteases to bind to the target cell?46
4839132057MACwhat do all 3 pathways end up producing?47
4839149330receptors on cells that are carrying immune complexes which will be read by macrophages so they only eat the immune complex and not the cell itselfwhat is CR1?48
4839153254prevents fusion of C4b AND C2a in the classical pathway prevents fusion of C3b AND Bb in the alternative pathwaywhat does DAF do?49
4839153685DAFwhat is the most important complement regulator in the circulation?50
4839156886prevents C5b67 from inserting into the target cells membranewhat does the S protein complement regulator do?51
48391609691. Amplifies humoral/acquired response 2. Destroys viruses/bacteria via MAC 3. Enhances inflammatory response via "a" 4. Opsonizes antigens 5. Neutralizes viruses 6. Clears immune complexesWhat are the 6 biological effects of complement activation?52
4839163108C3a, C4a, and C5awhat are the 3 anaphylatoxins?53
4839163651C5awhat peptide serves as a chemotaxin?54
4839165868C4b, C3b, and iC3bwhat peptides serve as opsonins?55
4839167224gram-positive bacteriawhat bacteria can resist lysis?56
4839168066tumor cells. they can endocytose the MAC and repair the missing piece of membranewhat cells are not affected by MAC? why?57
4839173308nocan the complement system be activated in a localized area of the body?58
4839174319yesis the complement system activated by tissue necrosis?59
4839175794paroxysmal nocturnal hemoglobinuriawhat disease involves a lack of DAF?60
4839177184staph and strep infectionsif these infections become recurrent the complement system may not have the ability to lyse the bacteria but does seem to control it61
4839183553paroxysmala severe attack or a sudden increase in intensity of a disease, usually recurring periodically62
48391859781. Immunologic assays 2. Classical pathway assays 3. Alternative pathway assays 4. Complement fixation testing4 lab tests to detect complement abnormalities63
4839188395immunologic assayswhat form of testing does RID and nephelometry fall under?64
4839189816when 50% of cells are lysedwhat does CH50 mean?65
4839192564detecting if an antibody is present which would imply an active infectionwhat is complement fixation testing really looking for to detect complement activation?66
4839195286Negative test, because the immune system was not already occupied with current infectionif the cells undergo lysis during complement fixation, what does that mean?67
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