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Evolution and Genetics: The Chromosomal Basis of Inheritence Flashcards

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320602651Chromosome Theory of InheritenceMendelian genes have specific loci positions along chromosomes, it is the chromosomes that undergo segregation and independent assortment
320602652Wild typeThe phenotype that is most commonly observed in natural populations
320602653Mutant PhenotypesAlternatives to the wild-type, most commonly caused by changes/mutations in alleles
320602654Sex-linked Genesa gene located on either sex chromosome
320602655HemizygousMale can't be homozygous/heterozygous for sex-linked genes/male only expresses at one locus
320602656Duchene Muscular Dystrophyaffects 1 in 3500 males results from absence of key muscle protein
320602657Hemophiliaabsence of one or more proteins required for blood clotting
320602658Linked GenesGenes located on the same chromosome that tend to be inherited together in genetic crosses
320602659Genetic RecombinationThe production of offspring with combinations of traits that differ from those found in either parent
320602660Parental TypesOffspring expected to inherit a phenotype that matches one of the parental phenotypes
320602661Recombinant TypesOffspring with new combinations
320602662Crossing OverThe reciprocal exchange of genetic material between nonsister chromatids during prophase 1 of meiosis
320602663Genetic MapAn ordered list of genetic loci along a particular chromosome
320602664NondisjunctionMembers of a pair of homologous chromosome don't move apart properly during meiosis 1 or sister chromatids fail to separate during meiosis II-one gamete receives extra copy, another one has no copy
320602665AneuploidyMay involve more than one chromosome-the zygote will have an abnormal number of chromosomes
320602666MonosomicFertilization involving a gamete that has no copy of a particular chromosome will lead to a missing chromosome in the zygote 2n-1
320602667TrisomicIf a chromosome is present in triplicate in the zygote 2n+1
320602668PolyploidyOrganisms have more than two complete chromosome sets in all somatic cells: triploidy 3n or tetraploidy 4n: common in plant kingdom
320602669DeletionOccurs when a chromosomal fragment is lost—missing genes
320602670DuplicationThe deleted fragment may become attached as an extra segment to a sister chromatid
320602671InversionA chromosomal fragment may also reattach to the original chromosome but in reverse orientation
320602672TranslocationChromosomal breakage is for the fragment to join a nonhomologus chromosome
320602673Linkage MapA genetic map based on recombination frequencies

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