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Folate and B12 deficiency Flashcards

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4410402840What type of anaemia?Macrocytic0
4410408559Name 6 causes of b12 deficiencyVegan diet PA GAstrectomy Ileal resection Tropical sprue Crohn's Tapeworm1
44104162833 causes of folate deficiencyPoor diet (poverty/alcohol) Increased demand (high cell turnover inflammatory disease) Lactation2
4410429331What does Vitamin B12/cobalamin bind to in the stomach?IF3
4410435284What secretes intrinsic factor?Parietal cells4
4410438602Where is the b12 absorbed from?Terminal ileum5
4410439481Where is folate absorbed?PRoximal jejunum and duodenum6
4410444175Which tract is often spared in b12 deficiency?Spinothalamic7
4410446380Name 4 clinical features of b12 deficiencyLethargy/breathless Bruising/mucosal haemorrhage due to thormbocytopenia Weight loss due to malabsorption Sore mouth (mucosal changes) Peripheral neuropathy (due to myelin degeneration of the posterior/lateral columns of the spinal cord) -> spasticity, impaired sensation of lower limbs etc8
4410457695How would the blood film be for B12 and folate deficiency?High MCV Oval macrocytes on blood film9
4410460056How would you treat PA?Injections of b12 (IM/parenteral)10

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