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Hematology: Vitamin B12 deficiency Flashcards

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3283114120Pernicious anemiaImportant cause of B12 deficiency, autoantibodies to IF0
3283114121Pernicious anemia: type 1 antibody75% patients have this, which blocks binding of B12 to IF1
3283114122Pernicious anemia: type 2 antibodyPrevent binding of IF to ileal receptors2
3283114123Pernicious anemia: type 3 antibodyBlocks IF production, present in 85-90% of patients3
3283114124Pernicious anemia: principle alterationsInvolve the spinal cord, where therein is myelin degeneration of the dorsal and lateral tracts4
3283114125Pernicious anemia: clinical courseLarge RBC, decreased platelets and WBCs, increased segments in nucleus in neutrophils5
3283114126Schilling testUseful in distinguishing B12 deficiency due to malabsorption, dietary deficiency, or absence of IF6
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