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Mitosis - AP Biology Flashcards

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5384548452G1 PhaseFirst stage of interphase in which cell grows and performs its normal functions. Cell is diploid.0
5384548453G0 PhaseCell is performing its normal functions, but has left the cell cycle and is not dividing.1
5384548454S PhaseThe synthesis phase of the cell cycle; the portion of interphase during which DNA is replicated.2
5384548455G2 PhaseLast stage of interphase in which cell grows and performs its normal functions. Cell is tetraploid.3
5384548456InterphaseCell grows, performs its normal functions, and prepares for division; consists of G1, S, and G2 phases4
5384548457ProphasePhase of mitosis in which chromosomes condense, nuclear membrane disappears, nucleolus disappears, and spindle fibers begin to form.5
5384548458MetaphasePhase of mitosis in which spindle fibers help chromosomes line up on the midline of the cell.6
5384548459AnaphasePhase of mitosis in which the chromosomes separate and move to opposite ends of the cell.7
5384548460TelophasePhase of mitosis during which chromosomes uncoil, a nuclear envelope returns around the chromatin, and a nucleolus becomes visible in each daughter cell"8
5384548461CytokinesisAt the end of telophase, actin fibers form an equator around the cell and contract, separating the cytoplasm into two daughter cells.9
5384548462CentrioleA paired cluster of microtubules near the nucleus in animal cells. This organelle organizes spindle fibers during mitosis.10
5384548463CentromereRegion of a chromosome where the two sister chromatids attach to one another. Contains the kinetochore.11
5384548464KinetochoreA specialized region on the centromere that links each sister chromatid to the mitotic spindle.12
5384548465Spindle FibersMade of microtubules that connect centrioles to kinetochores of chromosomes and that separate sister (mitosis) or homologous (meiosis) chromosomes during cell division13
5384548466ChromosomeA threadlike, gene-carrying structure found in the nucleus. Each chromosome consists of one very long DNA molecule and associated proteins.14
5384548467ChromatidOne of two identical "sister" parts of a duplicated chromosome.15
5384548468HaploidA cell with only one copy of each chromosome.16
5384548469DiploidA cell with two copies of each chromosome.17
5384548470TetraploidA cell with four copies of each chromosome.18
5384548471KaryotypeMicrograph of the complete diploid set of chromosomes grouped together in pairs, arranged in order of decreasing size19
5384548472Cyclin-Dependent Kinase (CDK)A group of protein kinases that are activated by the formation of a complex with a cyclin and are involved in the regulation of the cell cycle. Only active when bound to a cyclin.20
5384548473CyclinA cellular protein that occurs in a cyclically fluctuating concentration and that plays an important role in regulating the cell cycle.21
5384548476p53This tumor suppressor gene causes cell cycle arrest in G1, providing time for DNA repair. If repair is successful, cells re-enter the cycle. If unsuccessful, apoptosis. Damage to this protein can cause cancer.22
5384548477Proto-oncogeneA normal cellular gene corresponding to an oncogene; a gene with a potential to cause cancer but that requires some alteration to become an oncogene.23
5384548478Tumor Suppressor GeneA gene whose protein products inhibit cell division, thereby preventing uncontrolled cell growth. Mutations in this gene can cause cancer.24
5384548479KinaseAn enzyme that adds a phosphate group to a protein. Phosphorylation usually activates protein activity.25
5384548480PhosphataseAn enzyme that removes a phosphate group from a protein. Phosphorylation usually activates protein activity.26
5384555906growth factorsFactors that stimulate the cell to divide.27
5384565273cancerDisorder in which some of the body's cells lose the ability to control growth; A disease in which the body cells grow & divide uncontrollably, damaging the parts of the body around them.28
5384586562metastisisspread of cancer cells29
5384588818treatments for cancersurgery; radiation; chemotherapy; immunotherapy30
5384614526angiogenesisthe process through which a tumor supports its growth by creating its own blood supply by recruiting new blood vessels31
5384623592normal cell cycle regulatorsadhesion; crowding/density-dependence; growth factors32

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